Cytotoxic and estrogenic activity of chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol. Study of marine yeasts as potential toxicity indicators

Echeverri-Jaramillo, Gustavo; Jaramillo-Colorado, Beatriz E.; Sabater-Marco, Consuelo; Castillo, M.A.

doi:10.1007/s10646-020-02315-z

Cited by 18 publications

(5 citation statements)

References 101 publications

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“…3,5,6-Trichloro-2-pyridinol (TCP) is a metabolite of chlorpyrifos [ 104 ], which is an organophosphate insecticide. It has been reported that TCP can reach groundwater and surface water, and its half-life in the soil can reach 120 days [ 167 ].…”

Section: Resultsmentioning

confidence: 99%

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Assessment of Xenoestrogens in Jordanian Water System: Activity and Identification

Akkam

Omari

Alhmoud

et al. 2023

Toxics

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Sex hormone disruptors (xenoestrogens) are a global concern due to their potential toxicity. However, to date, there has been no study to investigate the presence of xenoestrogen pollutants in the Jordanian water system. Samples in triplicates were collected from six locations in Jordan, including dams, surface water, tap or faucet water, and filtered water (drinking water—local company). Xenoestrogens were then extracted and evaluated with a yeast estrogen screen utilizing Saccharomyces cerevisiae. Later, possible pollutants were mined using ultrahigh-performance liquid chromatography (UPLC) coupled with a Bruker impact II Q-TOF-MS. Possible hits were identified using MetaboScape software (4000 compounds), which includes pesticide, pharmaceutical pollutant, veterinary drug, and toxic compound databases and a special library of 75 possible xenoestrogens. The presence of xenoestrogens in vegetable samples collected from two different locations was also investigated. The total estrogen equivalents according to the YES system were 2.9 ± 1.2, 9.5 ± 5, 2.5 ± 1.5, 1.4 ± 0.9 ng/L for King Talal Dam, As-Samra Wastewater Treatment Plant, King Abdullah Canal, and tap water, respectively. In Almujeb Dam and drinking water, the estrogenic activity was below the detection limit. Numbers of identified xenoestrogens were: As-Samra Wastewater Treatment Plant 27 pollutants, King Talal Dam 20 pollutants, Almujeb Dam 10 pollutants, King Abdullah Canal 16 pollutants, Irbid tap water 32 pollutants, Amman tap water 30 pollutants, drinking water 3 pollutants, and vegetables 7 pollutants. However, a large number of compounds remained unknown. Xenoestrogen pollutants were detected in all tested samples, but the total estrogenic capacities were within the acceptable range. The major source of xenoestrogen pollutants was agricultural resources. Risk evaluations for low xenoestrogen activity should be taken into account, and thorough pesticide monitoring systems and regular inspections should also be established.

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Section: Resultsmentioning

confidence: 99%

“…Therefore, the direct application of TCP might be the source of contamination [ 142 , 143 , 144 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 ]. Moreover, it has weak estrogenic activity, being 2500 times less estrogenic than 17β-estradiol [ 104 ].…”

Section: Resultsmentioning

confidence: 99%

Assessment of Xenoestrogens in Jordanian Water System: Activity and Identification

Akkam

Omari

Alhmoud

et al. 2023

Toxics

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“…Su efecto principal es la inhibición de la acetilcolinesterasa a nivel de la comunicación interneuronal a nivel central y periférico con efecto en varias regiones del organismo, como los pulmones (Yadala, 2020), con marcado efecto como disruptor endocrino (Ubaid Ur Rahman et al, 2021). Presenta efecto citotóxico y estrogénico tanto directamente como a través de su metabolito 3,5,6-tricloro-2-piridinol siendo este más dañino que el propio clorpirifos (Echeverri-Jaramillo et al, 2021). El clorpirifos aumentaría la expresión génica de genes proinflamatorios, como la interleukina 6, la interleukina 1β y el factor de necrosis tumoral α, entre otros; y genes apoptóticos como la caspasa 3; 8; y 9 (Kianpour et al, 2021).…”

Section: Plaguicidas No Autorizados Más Frecuentes En Los Cultivosunclassified

Use of unauthorized pesticides in primary agricultural foods, Peru (2011-2018)

Correa-Núñez¹,

Rojas‐Jaimes²

2022

Manglar

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El monitoreo de contaminantes que afecten la inocuidad de alimentos agropecuarios primarios se inició el año 2011 en el Perú. Se efectuó una revisión documental de los informes de monitoreo publicados en el sitio web del Servicio Nacional de Sanidad Agropecuaria del Perú (SENASA) entre los años 2011 a 2020, sin embargo no hubo información completa sobre la concentración de plaguicidas no autorizados (PNA) en relación al límite máximo de residuos y por región geográfica, y tipo de contaminante, particularmente los años 2019 y 2020 por lo que el análisis de restringe al período 2011-2018 verificándose el uso de no menos de 20 plaguicidas no autorizados de los cuales se han efectuado un mínimo de dos aplicaciones por cultivo, siendo los cultivos con mayor uso de PNA el limón (7 PNA); tomate, mandarina y uvas (5 PNA); banano (4 PNA); y naranjas y pallar (3 PNA), siendo clorpirifos y carbendazim los PNA que fueron utilizados hasta en cinco cultivos lo que se explicaría por su amplio espectro de acción. Se requiere monitoreo para determinar las concentraciones de los PNA según cultivo, en relación a los límites máximos de residuo, y al período de retiro.

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“…Chlorpyrifos (CP) is one of the most used, broad-spectrum, organophosphorous insecticides. 2 Its mode of insecticidal action involves inhibition of acetyl cholinesterase (neural enzyme) activity, resulting in loss of muscular coordination, convulsions, and ultimately death of the target organism. However, its non-selective nature against target and non-target organisms has classified it as a moderately hazardous class-II pesticide, by the WHO.…”

Section: Introductionmentioning

confidence: 99%

Tri-metallic ZIF mediated synthesis of defect rich N-doped Co₃O₄/ZnO/NiO S-scheme heterostructure for detection and photocatalytic degradation of persistent organic pollutants

Abhivyakti

Renu

Singh

et al. 2023

Environ. Sci.: Nano

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Cytotoxic and estrogenic activity of chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol. Study of marine yeasts as potential toxicity indicators

Cited by 18 publications

References 101 publications

Assessment of Xenoestrogens in Jordanian Water System: Activity and Identification

Assessment of Xenoestrogens in Jordanian Water System: Activity and Identification

Use of unauthorized pesticides in primary agricultural foods, Peru (2011-2018)

Tri-metallic ZIF mediated synthesis of defect rich N-doped Co₃O₄/ZnO/NiO S-scheme heterostructure for detection and photocatalytic degradation of persistent organic pollutants

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Cytotoxic and estrogenic activity of chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol. Study of marine yeasts as potential toxicity indicators

Cited by 18 publications

References 101 publications

Assessment of Xenoestrogens in Jordanian Water System: Activity and Identification

Assessment of Xenoestrogens in Jordanian Water System: Activity and Identification

Use of unauthorized pesticides in primary agricultural foods, Peru (2011-2018)

Tri-metallic ZIF mediated synthesis of defect rich N-doped Co3O4/ZnO/NiO S-scheme heterostructure for detection and photocatalytic degradation of persistent organic pollutants

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Tri-metallic ZIF mediated synthesis of defect rich N-doped Co₃O₄/ZnO/NiO S-scheme heterostructure for detection and photocatalytic degradation of persistent organic pollutants