Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells

Asare, Nana; Instanes, Christine; Sandberg, Wiggo J.; Refsnes, Magne; Schwarze, Per E.; Kruszewski, Marcin; Brunborg, Gunnar

doi:10.1016/j.tox.2011.10.022

Cited by 266 publications

(157 citation statements)

References 51 publications

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“…These observations were confirmed by Asare et al 2012, who reported cytotoxicity of 20 and 200 nm sized Ag-NP in murine primary testicular cells from the lowest tested concentration of 10 µg/mL. These results indicate that testicular cells are sensitive for the toxic effects of Ag-NP, although it is questionable whether this also indicates reproductive toxicity.…”

Section: In Vitro Reproductive and Developmental Toxicitysupporting

confidence: 60%

“…In Ntera2 human testicular embryonic NT2 cells, Ag-NPs (nominal size 20 nm, coating not indicated) and especially sub-microsized Ag particles (nominal size 200 nm, coating not indicated) induced DNA damage (tested doses 12.5-100 µg/mL) as measured by the comet assay, especially without using FpG (Asare et al 2012); no induction of DNA damage was seen in primary testicular cells from wild-type or 8-oxoguanine DNA glycosylase knock-out (mOgg1 -/-) mice after treatment with these particles (tested up to 100 µg/mL).…”

Section: In Vitro Genotoxicity Studiesmentioning

confidence: 99%

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Potential risks and benefits of nanotechnology: perceptions of risk in sunscreens

Wright

2016

Medical Journal of Australia

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Section: In Vitro Reproductive and Developmental Toxicitysupporting

confidence: 60%

Section: In Vitro Genotoxicity Studiesmentioning

confidence: 99%

Potential risks and benefits of nanotechnology: perceptions of risk in sunscreens

Wright

2016

Medical Journal of Australia

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“…Another important example of the ENM which raises toxicological concerns due to its widespread use in consumer products is nano-silver. Although nano-silver was known to be harmless, recent studies (Asare, et al, 2012;Foldbjerg, Dang, & Autrup, 2011;Hussain, et al, 2006;Kim, et al, 2009) have provided convincing evidence of toxicity associated with the exposure to nano-silver. More detailed information about the potential adverse effects of various NMs has been provided by several researchers (Arora, et al, 2012;Holgate, 2010;Horie & Fujita, 2011;Jeng & Swanson, 2006;Magrez, et al, 2006;Saquib, et al, 2012;Sharifi, et al, 2012;Wani, Hashim, Nabi, & Malik, 2011).…”

Section: Nanomaterials Toxicitymentioning

confidence: 99%

(Q)SAR modelling of nanomaterial toxicity: A critical review

et al. 2015

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There is an increasing recognition that nanomaterials pose a risk to human health, and that the novel engineered nanomaterials (ENMs) in the nanotechnology industry and their increasing industrial usage poses the most immediate problem for hazard assessment, as many of them remain untested. The large number of materials and their variants (different sizes and coatings for instance) that require testing and ethical pressure towards non-animal testing means that expensive animal bioassay is precluded, and the use of (quantitative) structure activity relationships ((Q)SAR) models as an alternative source of hazard information should be explored.(Q)SAR modelling can be applied to fill the critical knowledge gaps by making the best use of existing data, prioritize physicochemical parameters driving toxicity, and provide practical solutions to the risk assessment problems caused by the diversity of ENMs. This paper covers the core components required for successful application of (Q)SAR technologies to ENMs toxicity prediction, and summarizes the published nano-(Q)SAR studies and outlines the challenges ahead for nano-(Q)SAR modelling. It provides a critical review of (1) the present status of the availability of ENMs characterization/toxicity data, (2) the characterization of nanostructures that meets the need of (Q)SAR analysis, (3) the summary of published nano-(Q)SAR studies and their limitations, (4) the in silico tools for (Q)SAR screening of nanotoxicity and (5) the prospective directions for the development of nano-(Q)SAR models.

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“…The ROS are highly reactive molecules that can disturb the homeostasis of the intracellular milieu and cause breakdown of membrane lipids, and cause DNA damage (Barillet et al, 2010;Oberdörster et al, 2005;Oberdörster et al, 2007;Papageorgiou et al, 2007). Similarly, recent in vitro studies demonstrated that NPs induce oxidative stress and inflammatory responses leading to genotoxicity and cytotoxicity in cells Asare et al, 2012;Kumar et al, 2011;Patil et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

Hamzeh

Sunahara

2013

Toxicology in Vitro

124

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/npsi/ctrl?lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?lang=fr Access and use of this website and the material on it are subject to the Terms and Conditions set forth at http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. For the publisher's version, please access the DOI link below./ Pour consulter la version de l'éditeur, utilisez le lien DOI ci-dessous.http://dx.doi.org/10. 1016/j.tiv.2012.12.018 Toxicology in Vitro, 27, 2, pp. 864-873, 2012-12-28 In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells Hamzeh, Mahsa; Sunahara, Geoffrey I. Therefore, our objective was to investigate the cytotoxicity and genotoxicity of commercially available TiO 2 nanoparticles with respect to their selected physicochemical properties, as well as the role of surface coating of these nanoparticles. While all types of tested TiO 2 samples decrease cell viability in a mass-based concentration-and size-dependent manner, the polyacrylate-coated nano-TiO 2 product was only cytotoxic at higher concentrations. A similar pattern of response was observed for induction of apoptosis/necrosis, and no DNA damage was detected in the polyacrylate-coated nano-TiO 2 model. Given the increasing production of TiO 2 nanoparticles, toxicological studies should take into account the physiochemical properties of these nanoparticles that may help researchers to develop new nanoparticles with minimum toxicity.

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Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells

Cited by 266 publications

References 51 publications

Potential risks and benefits of nanotechnology: perceptions of risk in sunscreens

Potential risks and benefits of nanotechnology: perceptions of risk in sunscreens

(Q)SAR modelling of nanomaterial toxicity: A critical review

In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells

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