Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms

Abstract

The toxic potential at the cellular level of industrialized Ginkgo biloba L. leaves was evaluated in meristematic cells of Allium cepa at concentrations of 0.1; 0.2 and 0.4 mg/ml. The industrialized products, from four pharmaceutical laboratories, were identified as A, B, C and D. Cell-level toxicity of dehydrated ginkgo leaf tea was also evaluated at concentrations of 0.15; 0.30 and 0.60 mg/ml. Dehydrated products were purchased from herbalists certified by ANVISA. The roots were exposed to teas and processed products for 24 and 48 hours. The results were submitted to the Chi-square test at 5%. However, industrialized ginkgo products at all concentrations caused antiproliferative effect. Also, the products purchased in pharmacies did not induce significant changes to root meristems. Therefore, industrialized ginkgo promoted cytotoxicity, however, they were not genotoxic to the bioassay used.

Antiproliferative, genotoxic and mutagenic potential of synthetic chocolate food flavoring

“…This condition suggests an aneugenic effect of the chocolate flavoring on plant meristematic tissues. Guedes et al (2018) report that the occurrence of many cells arrested in prophase signal the presence of chemical agents that slow or stop the mitotic machinery, causing the cell cycle to occur less frequently or, in fact, to stop.…”

Ecologia De Fitofisionomias Da Floresta Nacional De Carajás: Floresta Ombrófila Densa, Campo Rupestre Ferruginoso E Ecótono Floresta-Cerrado

“…De acordo com Herrero et al (2012) e Guedes et al (2018), índices mitóticos significativamente inferiores aos índices do controle negativo, como observado para as águas de P1, P3, P5 e P10, podem indicar a presença de agentes cuja ação tóxica compromete o crescimento e desenvolvimento dos organismos expostos. Ademais, esses autores declaram que a inibição da proliferação celular desencadeada por compostos citotóxicos em tecidos de intensa proliferação celular e com desempenho normal -como os meristemas de raízes utilizados nesta pesquisa -é bastante prejudicial ao organismo por inibir ou limitar a reposição de células, alterar a produção de proteínas e resultar no mal funcionamento do órgão onde está localizada.…”