Cytotoxic compounds against cancer cells from Bombyx mori inoculated with Cordyceps militaris

Abstract

Two compounds, 3'-deoxyinosine and cordycepin, were isolated from Bombyx mori inoculated with Cordyceps militaris. In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells.

Hepialiamides A–C: Aminated Fusaric Acid Derivatives and Related Metabolites with Anti-Inflammatory Activity from the Deep-Sea-Derived Fungus Samsoniella hepiali W7

“…By comparing the NMR, MS, ECD, and OR data with those reported in the references, 18 previously described components were identified as cordycepin (5) [28], adenosine (6) [29], 3 -deoxyinosine (7) [30], 5 -O-acetyladenosine (8) [31], 5 -acetyl-3 -deoxyadenosine (9) [32], thymidine (10) [33], uridine (11) [34], 5 -O-acetyluridine (12) [35], ergosterol (13) [36], 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one ( 14) [37], 12-acetoxycycloneran-3,7diol (15) [38], dibutyl phthalate ( 16) [39], di-(2-ethylhexyl)phthalate ( 17) [40], oryzasaccharide A (18) [41], D-glucopyranoside, ethyl, 6-acetate (19) [42], 6-O-acetyl-D-glucose (20) [43], walterolactone A (21) [44], and (4R,5S)-5-hydroxyhexan-4-olide (22) [45]. Among them, 16 and 17 were previously described as plasticizers and common contaminants in natural products [46].…”

Unravelling the potential of insects for medicinal purposes – A comprehensive review

“…In addition, the antioxidant [ 225 ], anti-inflammatory [ 76 ], and immunomodulatory [ 74 ] functions of insect-derived ingredients contribute to their antitumor effects. Cantharidin from blister beetles (Meloidae) [ 153 ], cordycepin [ 161 ], and cecropin [ 146 ] from silkworms (Bombycidae) have gain many attentions with their anti-tumor effects. Since the cantharidin has certain toxic side effects, a synthetic derivation of cantharidin named noncantharidin has been developed and widely used in modern anti-tumor medicine [ 81 ].…”

Metabolites and Their Bioactivities from the Genus Cordyceps

“…Two new nucleosides, N6-4-methylbutyrat-adenosine ( 2 ) and 3′-deoxy-6- O -methylinosine ( 3 ), were isolated from C. militaris and did not show anti-inflammatory inhibitory activity under 100 μM [ 10 ]. 3’-Deoxyinosine ( 4 ) was isolated from C. militaris and showed a weak toxic effect on cancer cells A549, PANC-1 and McF-7 and exhibited powerful cytotoxicity against MCF-7 cells at a concentration of 30 μM [ 11 ]; moreover, it was previously reported to have antigenic activity. In addition, when compound 4 was combined with doxorubicin, it inhibited the metastasis and proliferation of breast cancer cells.…”