Cytotoxic constituents of Achillea clavennae from Montenegro

Peroxy natural products

“…193 Another bisabolene derivative 341 was found from the aerial parts of Achillea clavennae. 194 A germacranolide peroxide 342 was identified as a component of mulgedium tataricum. 170 Chemical investigation of Santolina insularis afforded two germacrane sesquiterpene peroxides 343 and 344, which might derive from the formal photo-oxygenation of the corresponding ∆ 4,5 olefin, a reaction well precedented in medium-sized olefins.…”

Variability of phenolic compounds in flowers of Achillea millefolium wild populations in Lithuania

“…Recent attention has been directed towards the dicaffeoylquinic acids present in yarrow, since these phenolic acids were shown to cause the choleretic effects (10). Two flavonoids casticin (11) and centaureidin (12), respectively, derived from A. millefolium and A. clavennae L., were Medicina (Kaunas) 2008; 44 (10) EKSPERIMENTINIAI TYRIMAI observed to exert cytotoxic activity. The results from in vitro assay, based on recombinant MCF-7 cells, indicated that flavonoids from A. millefolium exhibit estrogenic activity (13).…”

Assessments of Immunological Activity of Achillea Millefolium Methanolic Extract on Albino Male Mice

“…The study concluded that the components of A. millefolium act by different mechanisms sequestering reactive oxygen species. Additionally, several studies have confirmed that the pharmacological properties of A. millefolium are attributed mainly to the presence of favonoids as a result of their action against free radicals [19], and these polyphenols interfere not only with the propagation but also with the formation of free radicals both by chelating transition metals and by inhibiting enzymes involved in the initiation reaction [20]. Administration of methanol extract of A. millefolium led to significant increase in the levels of white blood cells that may have immune boosting properties.…”