Cytotoxic Constituents of Polyalthia longifolia var. pendula

Chen, Chung‐Yi; Chang, Fang Rong; Shih, Yao Ching; Hsieh, Tian Jye; Chia, Yi Chen; Tseng, Huang Yi; Chen, Hua Chien; Chen, Shu Jen; Hsu, Ming‐Chen; Wu, Yang Chang

doi:10.1021/np000176e

Cited by 100 publications

(73 citation statements)

References 32 publications

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“…Moreover, the bark is also used to treat bone fracture, gastric ulcer, and digestive and urinary disorders (Moniruzzaman et al, 2015). , extracted from the bark of p. longifolia, exhibits strong anti-inflammatory activity (Chang et al, 2006;Chen et al, 2000), regulates the expression of histone modifying enzymes PRC2 complex, and induces apoptosis in CML K562 cells (Lin et al, 2011). Many natural compounds and certain chemotherapeutic drugs are shown to trigger caspase-independent autophagic cell death by activating autophagy signaling pathways (Kondo et al, 2005;Xu et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

16-hydroxy-cleroda-3,13-dien-16,15-olide induced glioma cell autophagy via ROS generation and activation of p38 MAPK and ERK-1/2

Thiyagarajan

Sivalingam

Viswanadha

et al. 2016

Environmental Toxicology and Pharmacology

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Section: Introductionmentioning

confidence: 99%

16-hydroxy-cleroda-3,13-dien-16,15-olide induced glioma cell autophagy via ROS generation and activation of p38 MAPK and ERK-1/2

Thiyagarajan

Sivalingam

Viswanadha

et al. 2016

Environmental Toxicology and Pharmacology

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“…longifolia var. pendula has been less investigated compared with P. longifolia (Chen et al, 2000;Hara et al, 1995). Recent studies on its stem, roots, root bark and their isolates showed excellent antibacterial potency (Faizi et al, 2000(Faizi et al, , 2003a(Faizi et al, , 2003b) and significant hypotensive activity (Faizi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries

Faizi

Khan

Mughal

et al. 2008

Phytotherapy Research

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Methanol extracts of leaves, stem, twigs, green berries, flowers, roots, root-wood and root-bark of Polyalthia longifolia var. pendula, were tested for their antibacterial and antifungal potentials. Bioassay monitored isolation work on the methanol extract of leaves and berries which possess promising antibacterial activity led to the isolation of seven clerodane diterpenoids, 16(R and S)-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (1), 16-oxo-cleroda-3,13(14)E-dien-15-oic acid (2), methyl-16-oxo-cleroda-3,13(14)E-dien-15-oate (3), 2-oxo-kolavenic acid (4), 16 (R and S)-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide-2-one (5), (4-->2)-abeo-16(R and S)-hydroxy-cleroda-2,13(14)Z-dien-15,16-olide-3-al (6), 3beta,16alpha-dihydroxy-cleroda-4(18), 13(14)Z-dien-15,16-olide (7), while kolavenic acid (8) and solidagonal acid (9) were obtained from the root-wood. Diterpenoids 1 and 8 were also obtained from the root-bark. It is the first report of the isolation of 7 and 9 from this source, and clerodane 3 was obtained as a natural product for the first time. Clerodanes 1, 2, 5, 6 and 7 were found to be active antimicrobial agents with MIC values ranging between 7.8 and 500 microg/mL. Diterpenoid 1 emerged as the most active antimicrobial agent. The acetyl derivative (10) of 1 and the methyl derivative (3) of 2 were found to be less active than the parent compounds. A complex of allantoin was also obtained from the berries, which on hydrolysis furnished pure allantoin (11).

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“…It is used as an antipyretic agent in indigenous systems of medicine (Khatoon, 1985). Biological evaluation of the plant has resulted in the isolation of diterpenes and alkaloids which have been reported to be cytotoxic against human cancer cell lines (Chen et al, 2000) and to possess antimicrobial (Ferdous et al, 1992;Rashid et al, 1996) activity. Recently, a lactone with promising antibacterial activity has been isolated from the stem (Faizi et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Hypotensive activity and toxicology of constituents from root bark ofPolyalthia longifolia var.pendula

Saleem

Ahmed

et al. 2005

Phytother. Res.

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A defatted extract of Polyalthia longifolia var. pendula root bark (PRB) in 50% methanol showed a significant ability to reduce blood pressure. It caused a 22% and 47% fall in mean arterial blood pressure (MABP) in rats at doses of 3 mg/kg and 30 mg/kg, respectively. Compounds purified from this extract include kolavenic acid (3), clerodane (1) and its isomer (2), liriodenine (4), lysicamine (5) and bisclerodane imide (6) and its isomer (7). Of these, only kolavenic acid produced a 22% fall in MABP, at a dose of 30 mg/kg. PRB showed a decrease in blood pressure of normotensive and egg yolk induced hypertensive rats. The LD50 of PRB was determined as 100 mg/kg in mice.

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Cytotoxic Constituents of Polyalthia longifolia var. pendula

Cited by 100 publications

References 32 publications

16-hydroxy-cleroda-3,13-dien-16,15-olide induced glioma cell autophagy via ROS generation and activation of p38 MAPK and ERK-1/2

16-hydroxy-cleroda-3,13-dien-16,15-olide induced glioma cell autophagy via ROS generation and activation of p38 MAPK and ERK-1/2

Antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries

Hypotensive activity and toxicology of constituents from root bark ofPolyalthia longifolia var.pendula

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