Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots

Liu, Jie‐Qing; Yang, Yuanfeng; Xia, Jianjun; Li, XuYang; Li, Zhongrong; Zhou, Lin; Qiu, Ming‐Hua

doi:10.1016/j.phytochem.2015.07.002

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…Significant CH 4 reductions recorded for J. curcas could be partly attributed to the presence of inhibitory agents. The effectiveness of this plant at reducing CH 4 in the rumen might be related to its purgative, anthelminthic and antiseptic properties (Kumar et al 2016;Liu et al 2015). The extract would have reduced CH 4 production by combating the methanogens.…”

Section: Parametersmentioning

confidence: 99%

The use of certain medicinal plant extracts reduced in vitro methane production while improving in vitro organic matter digestibility

Akanmu

Hassen

2018

Anim. Prod. Sci.

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Some medicinal plants have the tendency to manipulate the rumen microbial ecosystem, which in turn might reduce methane (CH4) emissions. The anti-methanogenic activities of leaf fraction of Piper betle, Aloe vera, Carica papaya, Azadirachta indica, Moringa oleifera, Tithonia diversifolia, Jatropha curcas and Moringa oleifera pods were studied at different doses. The plant materials were extracted with pure methanol and subsequently reconstituted at the rate of 25, 50, 75 and 100 mg in 1000 mL distilled water. Four mL of each plant extracts preparation was anaerobically incubated with 400 mg Eragrostis curvula hay in four replicates and the experiment was repeated five times. Plant extracts of P. betle and A. vera significantly increased total gas produced whereas other extracts recorded lesser or similar values to the control group. Leaf extracts of A. indica, C. papaya, J. curcas, M. oleifera, T. diversifolia and M. oleifera pods all significantly reduced CH4 volume at dosages of 25 and 50 mg/L due to the activities of their phytochemicals. Total volatile fatty acids and in vitro organic matter digestibility values recorded for all extracts were generally superior when compared with the control. Methane yield per unit of total gas were significantly lower in extracts of T. diversifolia, M. oleifera, A. indica, M. oleifera pods whereas it is higher in P. betle and A. vera. It can be concluded from the study that methanolic extracts of A. indica, C. papaya, J. curcas, M. oleifera, M. oleifera pods and T. diversifolia resulted in reduced CH4 production, and thus can be used potentially to manipulate rumen condition, improve feed digestibility and reduce enteric CH4 emission from ruminants. However, the in vitro results needs to be verified using in vivo studies by administering concentrated crude extracts at a rate of 25 mg or 50 mg per kg of roughage feed for small ruminants.

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Section: Parametersmentioning

confidence: 99%

The use of certain medicinal plant extracts reduced in vitro methane production while improving in vitro organic matter digestibility

Akanmu

Hassen

2018

Anim. Prod. Sci.

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“…J. curcas shell is rich in phenolic compounds with high antioxidant activity [10] and fatty acids [11]. The constituents of J. curcas include curcin, with hemagglutinating activity [12], phorbol esters [13], lathyranlactone, jatrocurcasenones A-E and jatrophodiones B-E with cytotoxic activity [14], curcusones A-E, jatrogrossidione and 2-epi-jatrogrossidione, reported for their cytotoxity [15], isoamericanol A, which has an inhibitory effect on cell proliferation of MCF-7 [16], curcacycline A, which displays a moderate inhibition of proliferation of human T-cells [17], and curcacycline B, known to enhance the rotamase activity of human cyclophilin B [18]. Phytol (47.42%) in the leaf, 1butoxyperethyl-homotetrasilsesquioxane (36.11%) in the petiole, 7benzyl-8-(methylthio)theophyllin (12.53%) in the stem, as well as -gurjunene (13.99 %), β-elemol (13.45%) and guaiene (13.13%) in the root, were major components present in the essential oil [19].…”

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confidence: 99%

Composition and Anti-inflammatory Activity of Essential Oil of Jatropha Curcas

Adeosun

Ogunwande

Avoseh

et al. 2017

Natural Product Communications

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The chemical constituents and anti-inflammatory activity of the essential oil from the leaf of Jatropha curcas L (Euphorbiaceae) collected from Nigeria are reported. The analysis of the chemical constituents of the essential oil was achieved by using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). All constituents of the essential oil, namely neophytadiene (35.8%), phytol (23.1%), trans-pinane (12.7%), 6,10,14-trimethyl-2pentadecanone (12.3%) and citronellyl propanoate (11.2%), were present in significant amounts. The anti-inflammatory activity of the leaf oil was determined on Wistar rats using egg-albumin as phlogistic agent; significant inhibition (P< 0.05) was shown at a dose of 2%, v/v. Percentage inhibition of the antiinflammation increased steadily to 76.6% in the 4 th hour.

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“…Jarak mengandung senyawa aktif seperti kurkuson A, B, C dan D yang sangat Gambar 3.Gambaran histopatologi gigi setelah terpapar dengan bahan uji selama 7 hari yang diamati menggunakan mikroskop 40x10 toksik dengan EC 50 secara berturut-turut adalah 0,21; 0,27; 0,08 dan 0,16 μg/mL terhadap sel lymphoblast 13 . Liu et al berhasil mengisolasi senyawa turunan jatrokurkuson, jatrodion dan 10 analognya yang sangat toksik terhadap sel kanker 14 . Kematian sel saraf pulpa setelah terpapar dengan campuran getah jarak dan akar sidaguri dapat dilihat pada Gambar 3.…”

Section: Diskusiunclassified

POTENSI KOMBINASI EKSTRAK AKAR SIDAGURI (Sida rhombifolia L.) DAN GETAH JARAK (Jatropha curcas L.) SEBAGAI BAHAN DEVITALISASI

Tanumihadja

Mattulada

Natsir

et al. 2019

ODONTO : Dental Journal

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Background: Arsenic paste was used to devitalize dental pulp in some problems before surgical, but it has been proven to have many hazardous effects. So, other alternative drugs are needed that are equally effective but safer. Jatropha (Jatropha curcas L.) can cause lysis blood vessels in the pulp, whereas the sidaguri (Sidarhombifolia L.) are effective in relieving inflammation. The purpose of this study was to determine the devitalization effect of jatropha and sidaguri on rabbit animal model.Method: Sidaguri roots were extracted using reflux method while jatropha sap was dried using lyophilization method. For easy application, the extract made into a paste (1; 1) and inserted into the cavity. After 7 days of exposure, the teeth were removed, calcified and followed to histopathological staining and COX-2 expression (IHC).Result: Histopathological examination showed that the paste was able to cause necrosis of pulp nerve. Higher dose of the drug increased the necrosis area, but the paste is not able to reduce COX-2 expression.Conclusion: It can be concluded that the paste has a potential to developed as devitalization agent although it is necessary to study to the reduce the inflammation process.

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Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots

Cited by 17 publications

References 24 publications

The use of certain medicinal plant extracts reduced in vitro methane production while improving in vitro organic matter digestibility

The use of certain medicinal plant extracts reduced in vitro methane production while improving in vitro organic matter digestibility

Composition and Anti-inflammatory Activity of Essential Oil of Jatropha Curcas

POTENSI KOMBINASI EKSTRAK AKAR SIDAGURI (Sida rhombifolia L.) DAN GETAH JARAK (Jatropha curcas L.) SEBAGAI BAHAN DEVITALISASI

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