2007
DOI: 10.1016/j.taap.2007.03.033
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Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination☆

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Cited by 99 publications
(49 citation statements)
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“…Micromolar BPA concentrations inhibited purified and microsomal aromatase activities (Benachour et al, 2007) and potentially reduced oestrogen synthesis by reducing aromatase activity in placental cells (Huang and Leung, 2009) or aromatase expression in granulosa cells (Kwintkiewicz et al, 2010). This is in line with other recent studies (Zhou et al, 2008;Huang and Leung, 2009).…”
Section: Effects On Receptors and Hormone Homeostasissupporting
confidence: 88%
“…Micromolar BPA concentrations inhibited purified and microsomal aromatase activities (Benachour et al, 2007) and potentially reduced oestrogen synthesis by reducing aromatase activity in placental cells (Huang and Leung, 2009) or aromatase expression in granulosa cells (Kwintkiewicz et al, 2010). This is in line with other recent studies (Zhou et al, 2008;Huang and Leung, 2009).…”
Section: Effects On Receptors and Hormone Homeostasissupporting
confidence: 88%
“…Environmental exposure of pesticides is a significant health risk for humans and other animals [4-5-6]. Pesticides not only cause many chronic irregularities in human beings but may also degrade biodiversity and overall environmental quality [7][8]. To address this life-threatening environmental issue, different physicochemical methods such as incineration, land filling, burning or composting, and chemical amendments have been used over the last few decades to remove pesticide pollution from the contaminated environments [9-10-11-12-13-14-15 and 16].…”
Section: Introductionmentioning
confidence: 99%
“…For instance Roundup is known to disrupt the EPSPS in plants, but is also known to interact with the mammalian ubiquist reductase [21] common and essential to cytochromes P450, a wide class of detoxification enzymes. The so-called Roundup active principle, glyphosate, acts in combination with adjuvants to increase glyphosate-mediated toxicity [21,31], and this may apply to other environmental pollutants [22]. Moreover, all new metabolites in edible Roundup ready GMOs, as acetyl-glyphosate for the new GAT GMOs, have not been assessed for their chronic toxicity [11], and we consider this as a major oversight in the present regulations.…”
Section: Need For Chronic Tests and Other Testsmentioning
confidence: 99%