Cytotoxic Effects of Verbascoside on MCF-7 and MDA-MB-231

Şenol, Hülya; Tulay, Pınar; Ergören, Mahmut Çerkez; Hanoğlu, Azmi; Çalış, İhsan; Mocan, Gamze

doi:10.4274/tjps.galenos.2021.36599

Cited by 19 publications

(16 citation statements)

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“…Cytotoxic effect of condensed tannins was reported against MCF-7 and Hs 578T breast cancer cells, Caco-2 colon carcinoma cells, and DU 145 prostate cancer cells [ 105 ]. Cytotoxic effect against MDA-MB-231 (IC 50 = 0.159–0.258 μM) [ 106 ] and a range of other cancer cell lines, including U87 glioblastoma cell line, was reported for verbascoside [ 107 ], the major phenylethanoid of investigated species.…”

Section: Resultsmentioning

confidence: 99%

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

et al. 2022

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Species from the genus Globularia L. have been used as healing agents for various ailments, with utilization of Globularia alypum L. being most frequently reported. The aim of this study was to evaluate the antidiabetic, antioxidant, anti-inflammatory, antibacterial and anticancer potential of G. alypum and three related species, G. punctata Lapeyr., G. cordifolia L. and G. meridionalis (Podp.) O.Schwarz, in relation to their phytochemical compositions. Globularin and verbascoside were identified using LC-PDA-ESI-MSn as the major metabolites of G. alypum with known biological activities. G. alypum demonstrated the greatest α-glucosidase inhibitory activity and DPPH radical scavenging activity (IC50 = 17.25 μg/mL), while its anti-inflammatory activity was not significantly different from those of related species. All investigated species showed considerable antibacterial activity against methicillin-resistant Staphylococcus aureus in the broth microdilution method (MIC = 1.42–3.79 mg/mL). G. punctata also showed antibacterial activities against Escherichia coli (MIC = 1.42 mg/mL), Bacillus subtilis (MIC = 1.89 mg/mL), B. cereus (MIC = 2.84 mg/mL) and Enterococcus faecalis (MBC = 5.68 mg/mL). G. punctata, G. cordifolia and G. meridionalis showed greater anticancer potential than G. alypum. Obtained results indicate investigated Globularia species could serve as sources of diverse bioactive molecules, with G. punctata having the greatest antibacterial potential.

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Section: Resultsmentioning

confidence: 99%

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

et al. 2022

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“…The authors determined specific cytotoxicity against breast cancer cells, for MDA-MB-231 with LC 50 = 200 µM and for MCF7 with LC 50 = 150 µM. Other than OLE, cytotoxic effects on MCF-7 and MDA-MB-231 cell lines were also found significant for other phenolic compounds, such as verbascoside [ 76 ] and hydroxytyrosol [ 77 , 78 ]. Pentacyclic triterpenes are also potent cytotoxic molecules and are known to have a cytotoxic effect on all the cancer cell lines used in this study [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

In the Beginning Was the Bud: Phytochemicals from Olive (Olea europaea L.) Vegetative Buds and Their Biological Properties

et al. 2023

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Even though Olea europaea L. is one of the most important and well-studied crops in the world, embryonic parts of the plants remain largely understudied. In this study, comprehensive phytochemical profiling of olive vegetative buds of two Croatian cultivars, Lastovka and Oblica, was performed with an analysis of essential oils and methanol extracts as well as biological activities (antioxidant, antimicrobial, and cytotoxic activities). A total of 113 different volatiles were identified in essential oils with hydrocarbons accounting for up to 60.30% and (Z)-3-heptadecene being the most abundant compound. Oleacein, oleuropein, and 3-hydroxytyrosol had the highest concentrations of all phenolics in the bud extracts. Other major compounds belong to the chemical classes of sugars, fatty acids, and triterpenoid acids. Antioxidant, antimicrobial, and cytotoxic activities were determined for both cultivars. Apart from antioxidant activity, essential oils had a weak overall biological effect. The extract from cultivar Lastovka showed much better antioxidant activity than both isolates with both methods (with an oxygen radical absorbance capacity value of 1835.42 μM TE/g and DPPH IC50 of 0.274 mg/mL), as well as antimicrobial activity with the best results against Listeria monocytogenes. The human breast adenocarcinoma MDA-MB-231 cell line showed the best response for cultivar Lastovka bud extract (IC50 = 150 μg/mL) among three human cancer cell lines tested. These results demonstrate great chemical and biological potential that is hidden in olive buds and the need to increase research in the area of embryonic parts of plants.

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“…In addition, 100 μM of acteoside had the highest cytotoxic effect on MDA-MB 231 cells after 24, 48, and 72 h of exposure. The IC 50 values for 24, 48, and 72 h of acteoside exposure of MDA-MB 231 cells were 0.1597, 0.2584, and 0.2563 μM, respectively [ 40 ]. Due to the use of a different test and methodology, it is difficult to directly compare the results from this work and our experiment.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Effect of Phenylethanoid Glycosides Isolated from Plantago lanceolata L.

Budzianowska

Totoń

Romaniuk-Drapała

et al. 2023

Life

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The aim of the study is to investigate whether the bioactive compounds isolated from P. lanceolata inflorescences, namely, phenylethanoid glucosides, acteoside, plantamajoside, and a flavonoid, isorhamnetin-3-O-rutinoside-4′-O-glucoside, possessed cytotoxic activity against the selected cancer cell lines. The potential antitumor effects of two phenylethanoid glycosides and one flavonoid were evaluated via MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on seven human carcinoma cell lines (MCF-7, MDA-MB-231, Caco-2, HepG2, OVCAR-3, U138-MG, U251-MG) and one nontumorigenic mammary epithelial cell line (MCF-12A). For the first time, acteoside was studied in ovarian cancer cell line OVCAR-3, and plantamajoside in all cell lines except breast adenocarcinoma MDA-MB-281 and hepatocarcinoma HepG2. The phenylethanoid glycosides showed stronger cytotoxic activity than that of the glycoside flavonoid. Acteoside and plantamajoside, at concentrations of 200 and 300 μM, respectively, had a highly toxic effect on the selected two cancer cell lines of breast adenocarcinoma MDA-MB-231 and MCF-7, ovarian cancer cell line OVCAR-3, glioblastoma cell line U138-MG, and hepatocarcinoma cell line HepG2. Both glycosides were significantly less cytotoxic towards nontumorigenic cell line MCF-12A; the effect appeared at a concentration of 400 μM. For the first time, the activity of acteoside and plantamajoside was compared in one parallel investigation. The results are discussed against a broad background of existing knowledge on biological effects, their mechanisms, and structure–activity relationships. Phenylethanoids may be potential compounds with cytotoxic activity against the selected cancer types.

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Cytotoxic Effects of Verbascoside on MCF-7 and MDA-MB-231

Cited by 19 publications

References 0 publications

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

Globularia alypum L. and Related Species: LC-MS Profiles and Antidiabetic, Antioxidant, Anti-Inflammatory, Antibacterial and Anticancer Potential

In the Beginning Was the Bud: Phytochemicals from Olive (Olea europaea L.) Vegetative Buds and Their Biological Properties

Cytotoxic Effect of Phenylethanoid Glycosides Isolated from Plantago lanceolata L.

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