Cytotoxic evaluation of hydroxyapatite-filled and silica/hydroxyapatite-filled acrylate-based restorative composite resins: An in vitro study

Chadda, Harshita; Naveen, Sangeetha Vasudevaraj; Mohan, Saktiswaren; Satapathy, Bhabani K.; Ray, Alok R.; Kamarul, Tunku

doi:10.1016/j.prosdent.2015.12.013

Cited by 23 publications

(17 citation statements)

References 28 publications

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“…It was revealed that experimental composites had a better degree of conversion and minimal leaching of unreacted monomers when compared to commercial composites. The in vitro cytotoxicity of HA-based dental composites was evaluated and it was found that all experimental composites with HA and HA/silica were non-toxic, signifying that these composites exhibited favorable biological behavior which may also support cell proliferation 91) . Figure 3 shows the attachment of human bone marrow (hBM) mesenchymal stem cells (MSC) to all composite resins based on HA and HA/silica.…”

Section: Ha-based Dental Resinsmentioning

confidence: 99%

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A review of bioceramics-based dental restorative materials

Khan

Syed

2019

Dent. Mater. J.

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Currently, much has been published related to conventional resin-based composites and adhesives; however, little information is available about bioceramics-based restorative materials. The aim was to structure this topic into its component parts and to highlight the translational research that has been conducted up to the present time. A literature search was done from indexed journals up to September 2017. The main search terms used were based on dental resin-based composites, dental adhesives along with bioactive glass and the calcium phosphate family. The results showed that in 123 articles, amorphous calcium phosphate (39.83%), hydroxyapatite (23.5%), bioactive glass (16.2%), dicalcium phosphate (5.69%), monocalcium phosphate monohydrate (3.25%), and tricalcium phosphate (2.43%) have been used in restorative materials. Moreover, seven studies were found related to a newly developed commercial bioactive composite. The utilization of bioactive materials for tooth restorations can promote remineralization and a durable seal of the tooth-material interface.

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Section: Ha-based Dental Resinsmentioning

confidence: 99%

“…SEM images after 36 h of cell culturing on composite resins, (A) 100% resin matrix, (B) Resin matrix+HA30%, (C) Resin matrix+HA50%, (D)Resin matrix+HA15%/silica15%, and (E) Resin mastrix+ HA25%/silica25% (Courtesy to Chadda et al)91) .…”

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confidence: 99%

A review of bioceramics-based dental restorative materials

Khan

Syed

2019

Dent. Mater. J.

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“…In the contemporary dental medicine, reconstructive techniques hold a special territory, the most used materials being the composite materials, due to certain advantageous properties with a deep clinical impact, which include, among others, superior mechanical properties (stress resistance, resistance to impact and erosion, proper elasticity), thermal conductivity, water retention and reduced expansion coefficient, adherence, esthetic look, texture and surface properties that are adequate for the dental structure [1,2].…”

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confidence: 99%

Studies Regarding the Architectural Design of Various Composites and Nanofibres Used in Dental Medicine

Grădinaru¹,

Ignat²,

Dascălu³

et al. 2018

Rev. Chim.

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The aim of this study was represented by the definition and testing of a new formulation strategy and the functionality of composite materials, while ensuring the optimization of the relevant properties for the dental restoration processes through the use of precise techniques of characterization, the modification and functionality of the components in view of obtaining results that are characterized by an optimum biomechanical and bioactive relation, in full agreement with the particularities of the dental structure that requires restoration. In view of obtaining new resistant composite structures we made a number of 10 samples including extracted teeth with various losses of dental substance and the structural modifications included 3 types of composites, whose structure was improved by the introduction of inorganic fillings based on hydroxyapatite and silver nanoparticles. All these structures were reinforced with two types of fibers, Reforpost fiber glass kit (Angelus) and Fiber post Schulzer Pre-silanized; With regard to the use of composite structures improved by HA addition, we notice a slight lacunary structure on the SEM images due to the properties of HA, an aspect present at much smaller dimensions in the silver � HA mix. The size of the grains associated with their continuous uniformity and adherence for the fibrillar structure stands out at the samples with hydroxyapatite, the first place as uniformity and adherence going to the composite of the nanofiller technology category.

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“…The in vitro studies can be conducted under controlled conditions and provide a significant amount of information [38]. Different cell lines are used to probe the biocompatibility of dental materials like pulp cells extracted from the maxillary incisors of Sprague Dawley rats, multipotent stromal cells, human foreskin fibroblast, human lung fibroblast, primary human osteoblast, L929 mouse fibroblast, SV40 large T-antigen-transfected bovine dental pulpderived cells, MDPC-23 odontoblast-like cell line, primary pulp fibroblast, and human alveolar osteoblast, for example [39][40][41][42][43][44][45][46]. In this study, the MA-104 epithelial cell line was used because the glass ionomer cements are in direct contact with the epithelial tissue of the oral mucosa.…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility and Surface Characteristics of Resin-Modified Glass Ionomer Cements with Ammonium Quaternary Compounds or Silver Nanoparticles: AnIn VitroStudy

Munguía-Moreno

Martínez-Castañón

Patiño-Marín

et al. 2018

Journal of Nanomaterials

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Glass ionomer cements are materials with diverse clinical applications. Its use is indicated in patients with special needs, pediatric patients, and the elderly; accordingly, it is important to know its properties. The aim of the present study was to determine the cytotoxicity, surface roughness, microhardness, and surface characteristics of GC Fuji ORTHO LC and GC Fuji PLUS resin-modified glass ionomer cements (RMGICs) with 1 and 2% of benzalkonium chloride, cetylpyridinium chloride, hexadecyltrimethylammonium bromide, or silver nanoparticles. All the experimental groups increase or decrease statistically significantly the VHN (P<0.05) compared with the control group, except for GC Fuji PLUS added with hexadecyltrimethylammonium bromide 1 wt%. In the same way, all groups show a statistically significant (P<0.05) increase or decrease in Ra compared with the control group except for GC Fuji ORTHO added with benzalkonium chloride 2 wt%, GC Fuji PLUS added with benzalkonium chloride 2 wt%, and GC Fuji PLUS added with cetylpyridinium chloride 2 wt%. The SEM micrographs show similar surface images between the control and experimental groups. When a dental material is modified, it is important to reevaluate its biological and mechanical characteristics. In the present study, all the additions modified the cytotoxicity and surface characteristics of RMGICs, by increasing or decreasing these properties.

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Cytotoxic evaluation of hydroxyapatite-filled and silica/hydroxyapatite-filled acrylate-based restorative composite resins: An in vitro study

Cited by 23 publications

References 28 publications

A review of bioceramics-based dental restorative materials

A review of bioceramics-based dental restorative materials

Studies Regarding the Architectural Design of Various Composites and Nanofibres Used in Dental Medicine

Biocompatibility and Surface Characteristics of Resin-Modified Glass Ionomer Cements with Ammonium Quaternary Compounds or Silver Nanoparticles: AnIn VitroStudy

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