Cytotoxic Phenanthroindolizidine Alkaloids from the Roots ofFicus septica

Abstract

Activity-monitored fractionation of the CHCl3 solubles of the MeOH extract of the roots of Ficus septica using cytotoxicity assay led to the isolation of twenty phenanthroindolizidine alkaloids, including ten new ficuseptines E-N and ten known compounds. The cytotoxic effects of some of the isolates were tested on gastric adenocarcinoma (NUGC) and nasopharyngeal carcinoma (HONE-1) cell lines and the results demonstrated that, with the exception of dehydrotylophorine, all the tested compounds displayed pronounced cytotoxic activity with significant cell growth inhibitory effects. In addition, 13a R-antofine was found to be highly effective with ED(50) values of < 0.1 microg/mL against L-1210, P-388, A-549 and HCT-8 cell lines in another assay.

Antimalarial Phenanthroindolizine Alkaloids from <i>Ficus septica</i>

“…The chloroform-soluble portion showed the most potent antimalarial activity. Bioassay-guided fractionation resulted in the isolation of a new seco-phenanthroindolizinetype alkaloid, compound 1, along with three previously known compounds, dehydrotylophorine (2), 11) dehydroantofine (3), 18) and tylophoridicine D (4). 19) In this paper, we report the structures of 1 and antimalarial activities of all four isolated compounds (Fig.…”

Ficus septicaplant extracts for treating Dengue virusin vitro

“…In Papua New Guinea, this plant has been used as a medicine to treat illnesses such as cold, fever, gastralgia and fungal and bacterial disease (Holdsworth, Hurley & Rayner, 1980). Several bioactive compounds from F. septica identified include phenanthroindolizidine and aminocarophenone-and pyrrolidine-type alkaloids (Damu et al, 2005;Damu et al, 2009;Ueda, Takagi & Shin-ya, 2009). Among them, compounds of ficuseptine, 4,6-bis-(4-methoxyphenyl)-1,2,3-trihydroindolizidinium chloride and antofine isolated from methanolic extracts of F. septica leaves showed strong antibacterial and antifungal activities (Baumgartner et al, 1990).…”

Peer Review #2 of "Ficus septica plant extracts for treating Dengue virus in vitro (v0.1)"

“…Guinea, this plant has been used as a medicine to treat illnesses such as cold, fever, gastralgia and fungal and bacterial disease (Holdsworth et al, 1980). Several bioactive compounds from F. septica identified include phenanthroindolizidine and aminocarophenone-and pyrrolidine-type alkaloids (Damu et al, 2005;Damu et al, 2009;Ueda et al, 2009). Among them, compounds of ficuseptine, 4,6-bis-(4-methoxyphenyl)-1,2,3-trihydroindolizidinium chloride and antofine Manuscript to be reviewed isolated from methanolic extracts of F. septica leaves showed strong antibacterial and antifungal activities (Baumgartner et al, 1990).…”