Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021

Abstract

Eight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC50 values of 4.9 and 8.8 μM, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement.

Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01

“…Two new compounds sydoxanthone C (1) and acremolin B (2) along with 10 known compounds (3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were isolated from a deep-seaderived fungi Aspergillus sp. SCSIO Ind09F01.…”

“…Further solid-phase fermentation of Aspergillus sp. SCSIO Ind09F01 followed by its crude ethyl acetate (EtOAc) extract yielded two new compounds: sydoxanthone C (1) and acremolin B (2) together with 10 known compounds (3)(4)(5)(6)(7)(8)(9)(10)(11)(12): sydoxanthone B (3), 6 engyodontiumone B (4), 7 sydowinin B (5), 8 acremolin (6), 9 diorcinol (7), 10 cordyol C (8), 11 cordyol E (9), 12 methyl 2-hydroxy-4-(3-hydroxyl-5-methylphenoxy)-6-methylbenzoate(10), 13 3,7-dihydroxy-1,9-dimethyldibenzofuran (11) 14 and AGI-B4 (12) 15 ( Figure 1). The cytotoxicity and COX-2 inhibitory activities of these compounds were individually evaluated.…”

Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY2

“…The EtOAc extract of the fermentation was fractionated by repeated silica gel chromatography and Sephadex LH-20 column chromatography, as well as semi-preparative RP-HPLC, to yield the compounds 1 – 9 (Figure 1). The structure of two new benzophenone derivatives ( 1 – 2 ) were elucidated on the basis of MS, 1D, and 2D NMR data, and seven known xanthones were identified as conioxanthone A ( 3 ) [14], methyl 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate ( 4 ) [15], pinselin ( 5 ) [16], sydowinin B ( 6 ) [17], sydowinin A ( 7 ) [17], remisporine B ( 8 ) [18], and epiremisporine B ( 9 ) [18], by comparison of their spectroscopic data with those reported in the literature.…”

Global diversity and geography of planktonic marine fungi

“…Koenig, Spartina Schreb. ), manmade materials (polyurethane), and as parasites of marine animals (copepods, fish), algae (diatoms, brown seaweeds), corals, and sponges ( Chakrarvarity 1974, Pivkin 2000, Lin et al 2002, Nagai 2002, Proksch et al 2008, Zheng et al 2009, Pang et al 2011, Jones and Pang 2012b, Debbab et al 2013, Yao et al 2014, Gutiérrez et al 2016, Gnavi et al 2017, Raghukumar 2017, especially in pursuits of natural product discovery (Bugni and Ireland 2004, Pan et al 2008). Marine fungi have historically been defined as those capable of reaching reproductive maturity while completely or partially inundated with seawater salinity of at least 30 during some point in their life cycle (Johnson and Sparrow 1961), though broader definitions have since been applied (Pang et al 2016).…”