Cytotoxic Scalarane Sesterterpenes from a Sponge, <i>Hyrtios</i> <i>erecta</i>

Tsuchiya, Naho; Sato, Aiya; Hata, Tadashi; Sato, Noriko; Sasagawa, Kazuhiko; Kobayashi, T.

doi:10.1021/np970462z

Cited by 32 publications

(55 citation statements)

References 19 publications

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“…The results of these assays (see Table 3) show that all four compounds inhibit cell proliferation (GI 50 5-27 µM), with 4 being 3 times more potent than the other compounds at inhibiting cell growth. Considering our results in light of those from an SAR study by Sato et al, 21 who compared the anticancer activity of two tetraoxygenated sclaranes with aragusterols, confirms that a 3-keto group enhances activity over a 3R-or 3 -hydroxyl functional group. Oxygenation at C-3 appears to be necessary, as well as placement of If there is no hydroxyl group at any of these latter positions, aragusterols become inactive, 22 while multiple oxidation (hydroxyl and/or epoxide functionality) seems to enhance biological activity.…”

Section: Resultssupporting

confidence: 85%

Steroids from an Australian Sponge Psammoclema sp.

et al. 2009

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Investigation of an extract of the Australian marine sponge Psammoclema sp. for dynamin I inhibitory activity led to the isolation of four new trihydroxysterols (1-4) related to aragusterol G. These compounds were largely identified by 1D and 2D NMR spectroscopic methods. While 1 was found to be inactive in the dynamin bioassay, bioassays did reveal that compounds 1-4 inhibited the growth of colorectal, breast, ovarian, and prostate cancer cell lines (GI(50) 5-27 microM). The additional insight that these new compounds give to previous SAR studies is discussed briefly.

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Section: Resultssupporting

confidence: 85%

Steroids from an Australian Sponge Psammoclema sp.

et al. 2009

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“…In vivo, animals inoculated i.p. with P388 cells and injected i.p.with 0.5 to 8 mg/Kg of compound 1 on days 1, 5 and 9 after P388 cells injection lengthened their life span by 24%-74% [67]. Another sponge compound that demonstrated potent in vivo anticancer activity is B6.…”

Section: Spongesmentioning

confidence: 99%

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

et al. 2020

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The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. Interestingly, a large number of these compounds exert excellent antitumoral properties and have been developed as promising anticancer drugs that have later been approved or are currently under validation in clinical trials. However, due to the high need for these compounds, new methodologies ensuring its sustainable supply are required. Also, optimization of marine bioactives is an important step for their success in the clinical setting. Such optimization involves chemical modifications to improve their half-life in circulation, potency and tumor selectivity. In this review, we outline the most promising marine bioactives that have been investigated in cancer models and/or tested in patients as anticancer agents. Moreover, we describe the current state of development of anticancer marine compounds and discuss their therapeutic limitations as well as different strategies used to overcome these limitations. The search for new marine antitumoral agents together with novel identification and chemical engineering approaches open the door for novel, more specific and efficient therapeutic agents for cancer treatment.

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“…Scalarane sesterterpenes are characteristic secondary metabolites of some sponges. From a sponge, Hyrtios erecta, new eight scalarane sesterterpenes 307-314 have been isolated [111,112]. Generally, they are not functionalized on A-B-ring carbons, while antitumor compounds obtained from this sponge contain unique 3-oxygenated structures.…”

Section: Sesterterpenes (Table 11)mentioning

confidence: 99%

Cytotoxic Anticancer Candidates from Natural Resources

Kim¹,

Park²

2002

CMCACA

112

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Natural products have been regarded as important sources that could produce potential chemotherapeutic agents. Over 50% of anticancer drugs approved by United States Food and Drug Administration since 1960 were originated from the natural resources, especially from terrestrial plants. Based on cytotoxicity bioassay, over 400 compounds have been isolated from plants, marine organisms and microorganisms from the period of 1996 to 2000. Recently, interest of natural product research has slowly moved to marine organisms. As a result, almost 50% of reported cytotoxic compounds were isolated from marine organisms such as sponges and corals. Also, traditional cytotoxic compounds of acetogenins, alkaloids and terpene skeletons have been reported continuously. In this review, we will present the cytotoxic compounds obtained from natural sources from 1996 to 2000, and the structures and cytotoxic activity of natural compounds isolated from territorial, marine and microorganism resources.

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Cytotoxic Scalarane Sesterterpenes from a Sponge, Hyrtios erecta

Cited by 32 publications

References 19 publications

Steroids from an Australian Sponge Psammoclema sp.

Steroids from an Australian Sponge Psammoclema sp.

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

Cytotoxic Anticancer Candidates from Natural Resources

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