From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

Wang, Edina; Sorolla, Maria Alba; Krishnan, Priya Darshini Gopal; Sorolla, Anabel

doi:10.3390/biom10020248

Cited by 42 publications

(26 citation statements)

References 198 publications

(249 reference statements)

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“…En este contexto, se llevó a cabo un estudio de quimiomodulación de la actividad antiinflamatoria y antitumoral de una quimioteca obtenida a partir de dos diterpenos: ácido ent-kaurénico y ácido Adicionalmente se exploran nuevas fuentes de productos naturales poco estudiadas hasta ese momento. En concreto, la biodiversidad de los ecosistemas marinos resulta ser una fuente natural inagotable en el descubrimiento de nuevos fármacos antitumorales (11,12). Extractos obtenidos de numerosos invertebrados marinos (tunicados, corales, esponjas…) permitieron el aislamiento y la obtención de diversos fármacos.…”

Section: Los Primeros 30 Años (1940-1970s): "Screening Fenotípico"unclassified

Natural Products: From Traditional Medicine to Lead Compounds for Drug Development in the 21st Century

Polo¹

2021

an.ranf

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Natural products have historically contributed to drug discovery as a source of bioactive molecules, due to their great diversity and structural complexity. They have provided “lead” molecules for the development of drugs in different therapeutic areas, with a very prominent representation in the treatment of pain and inflammation, coagulation disorders, metabolic disorders, as well as in the treatment of cancer and infectious diseases. In recent decades there has been a paradigm shift in drug discovery strategies that has allowed the identification of new active natural products in therapeutic targets. Combinatorial Chemistry and biological tests (High Throughput Screening), together with the development of computational techniques, have contributed decisively to the design and optimization of libraries of natural product derivatives based on their biological activity. In parallel, technological advances in the field of Omics sciences and in data processing lead to a multidimensional approach in the drug discovery process. These powerful tools will allow the analysis of the pharmacological potential of natural products and their derivatives for the conversion of these molecules to active products with low toxicity. In the Precision Medicine era, natural products continue to be molecules with great potential in pharmaceutical development, since, unlike other therapeutic strategies, they have a favorable cost-benefit ratio, which will allow their future use in this discipline.

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Section: Los Primeros 30 Años (1940-1970s): "Screening Fenotípico"unclassified

Natural Products: From Traditional Medicine to Lead Compounds for Drug Development in the 21st Century

Polo¹

2021

an.ranf

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“…Among them, six are used in cancer therapy: Cytarabine (Ara-C), eribulin mesylate (E7389), trabectedin (ET-743), brentuximab vedotin (SGN-35), polatuzamab vedotin and aplidin [ 36 , 37 ]. In addition, many other compounds are currently under clinical investigations, between the Phase II and Phase III of clinical trials, with promising anticancer activities [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds of Marine Origin as Inducers of Immunogenic Cell Death (ICD): Potential Role for Cancer Interception and Therapy

Sansone

Bruno

Piscitelli

et al. 2021

Cells

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Regulated cell death (RCD) has always been considered a tolerogenic event. Immunogenic cell death (ICD) occurs as a consequence of tumour cell death accompanied by the release of damage-associated molecular patterns (DAMPs), triggering an immune response. ICD plays a major role in stimulating the function of the immune system in cancer during chemotherapy and radiotherapy. ICD can therefore represent one of the routes to boost anticancer immune responses. According to the recommendations of the Nomenclature Committee on Cell Death (2018), apoptosis (type I cell death) and necrosis (type II cell death) represent are not the only types of RCD, which also includes necroptosis, pyroptosis, ferroptosis and others. Specific downstream signalling molecules and death-inducing stimuli can regulate distinct forms of ICD, which develop and promote the immune cell response. Dying cells deliver different potential immunogenic signals, such as DAMPs, which are able to stimulate the immune system. The acute exposure of DAMPs can prime antitumour immunity by inducing activation of antigen-presenting cells (APC), such as dendritic cells (DC), leading to the downstream response by cytotoxic T cells and natural killer cells (NK). As ICD represents an important target to direct and develop new pharmacological interventions, the identification of bioactive natural products, which are endowed with low side effects, higher tolerability and preferentially inducing immunogenic programmed cell death, represents a priority in biomedical research. The ability of ICD to drive the immune response depends on two major factors, neither of which is intrinsic to cell death: ‘Antigenicity and adjuvanticity’. Indeed, the use of natural ICD-triggering molecules, alone or in combination with different (immuno)therapies, can result in higher efficacy and tolerability. Here, we focused on natural (marine) compounds, particularly on marine microalgae derived molecules such as exopolysaccharides, sulphated polysaccharides, glycopeptides, glycolipids, phospholipids, that are endowed with ICD-inducing properties and sulfavants. Here, we discuss novel and repurposed small-molecule ICD triggers, as well as their ability to target important molecular pathways including the IL-6, TNF-α and interferons (IFNs), leading to immune stimulation, which could be used alone or in combinatorial immunotherapeutic strategies in cancer prevention and therapies.

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“…This particularity has led to a constant description of bioactive metabolites from marine bacteria (Buijs et al, 2019;Puglisi et al, 2019). Marine compounds display high cytotoxicity; since the 1990s it was suggested that over 1% of the marine samples analyzed possesses antitumoral activity while the same is 0.2% of terrestrial samples (Wang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Bioprospecting Antiproliferative Marine Microbiota From Submarine Volcano Tagoro

et al. 2021

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Marine ecosystems are unique and rich reservoirs of biodiversity with high potential toward improving the quality of human life. The extreme physical–chemical conditions of the oceans have favored marine organisms to produce a great variety of new molecules as a mechanism to ensure their survival, and such compounds possess great biopharmaceutical interest. In particular, marine microbiota represent a promising and inexhaustible source for the development of new drugs. This work presents the taxonomic study of the samples obtained from the underwater volcano Tagoro, which has allowed us to develop a collection of 182 marine bacterial strains. On October 10th, 2011, at La Restinga–El Mar de Las Calmas Marine Reserve, an underwater eruption gave rise to a novel shallow submarine volcano at 1.8 km south of the island of El Hierro, Canary Islands, Spain. During the first 6 months, extreme physical–chemical perturbations, comprising thermal changes, water acidification, deoxygenation, and metal enrichment, resulted in significant alterations of the marine ecosystem. After March 2012, the submarine volcano Tagoro entered an active hydrothermal phase that involved a release of heat, gases, metals, and micronutrients that continues till our present. During 2016, our research team had the opportunity to participate in one of the monitoring oceanographic cruises carried out in the area in order to isolate microorganisms associated with both rock samples and deep-sea invertebrates over Tagoro submarine volcano. In this study, Proteobacteria revealed as the most abundant Phylum with 70.2% among all isolated strains, followed by Firmicutes 19%, Actinobacteria 9.5%, and Bacteroidetes 1.2%. Furthermore, we present the results of the antiproliferative assays of the extracts obtained from small-scale cultures of selected bacterial strains. An analysis of the effects of culture conditions in the antiproliferative activity showed that strains grown in Marine Broth (MB) presented lower GI50 values than those cultured in a modified medium (MM1). This effect is improved when the strains are incubated under agitation conditions. The antiproliferative potential of genera such as Halobacillus, Kangiella, Photobacterium, and Halomonas is revealed. Their biotechnological development provides an excellent starting point to access novel secondary metabolites and enzymes with potential for pharmaceutical and industrial applications.

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From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

Cited by 42 publications

References 198 publications

Natural Products: From Traditional Medicine to Lead Compounds for Drug Development in the 21st Century

Natural Products: From Traditional Medicine to Lead Compounds for Drug Development in the 21st Century

Natural Compounds of Marine Origin as Inducers of Immunogenic Cell Death (ICD): Potential Role for Cancer Interception and Therapy

Bioprospecting Antiproliferative Marine Microbiota From Submarine Volcano Tagoro

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