Cytotoxic sesquiterpenoid quinones from South China Sea sponge <i>Dysidea</i> sp

Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for their anticancer activity using a variety of cancer cell lines derived from humans and other sources, some of which have already been approved for clinical use, while some others are still being tested. These compounds can assault cancer cells via a variety of mechanisms, but certain cancer cells are resistant to them. As a result, the goal of this review was to look into the anticancer potential of marine natural products or their derivatives that were isolated from January 2019 to March 2020, in cancer cell lines, with a focus on the class and type of isolated compounds, source and location of isolation, cancer cell line type, and potency (IC50 values) of the isolated compounds that could be a guide for drug development.

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“…Cpds. 290 – 292 and 294 – 296 had moderate to good cytotoxic activity against several human cancer cell lines ( Table S2 ) [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review

et al. 2021

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“…sponges have also yielded (+)-19-methylaminoavarone ( 191 ), 20-methoxyneoavarone ( 192 ), 17- O -acetylavarol ( 193 ), 17- O -acetylneoavarol ( 194 ), 18-aminoarenarone ( 195 ), 19-aminoarenarone ( 196 ), 18-methylaminoarenarone ( 197 ), 19-methylaminoarenarone ( 198 ), smenospongimine ( 199 ), and melemeleones C and D ( 200–201 ). 55,109–112 We noticed that compounds 200 and 201 were both reported as new compounds; however, they are isomers of the reported compounds in terms of the stereogenic centers at C-5, C-8, C-9, and C-10, and the double bond positions in the sesquiterpenoid part. 84,109 Nakijiquinones L, K, N, O, Q, and R ( 202–207 ) were discovered from collections of Okinawan marine sponges of the family Spongiidae , and they possess unique side chains derived from amino acids.…”

Section: Structures Classifications and Distributions Of Natural Sqsmentioning

confidence: 91%

Natural sesquiterpene quinone/quinols: chemistry, biological activity, and synthesis

et al. 2023

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“…443 As always, isoprene-derived isolates are a dominant class of sponge metabolite. Mero-sesquiterpenoids were reported from the genera Hippospongia 1042-1044, Dactylospongia 1045-1048 and Dysidea 1049, respectively, 416,[444][445][446][447] while there was only one report of sponge-derived mero-diterpenoids, from Astroclera willeyana 1050-1052. 439 Several reports of new sesquiterpenoids were published in 2021.…”

Section: Reviewmentioning

confidence: 99%