Cytotoxic Steroids from the Bark of Aglaia argentea (Meliaceae)

Abstract

The study aimed to find a potential anticancer agent by isolating and identifying the chemical structure of compounds from Aglaia argentea and testing their cytotoxic effects against P-388 murine leukimia cells.

STEROIDS FROM THE SUPER RED DRAGON FRUIT (Hylocereus costaricensis)

“…The NMR spectra of 2 very similar with 1, the main difference was that compound 2 the absence of hydroxyl group at [δ H 4.21 (1H, m, H-7), δ C 74.5] and the presence of the methylene signal at [δ H 2.56 (1H, m, H-7a), 2.72 (1H, m, H-7b), δ C 32.4], suggested that 2 is 7-dehydroxy derivative of 1. In comparison of 2 with literature data of a stigmast-5-en-3βol (β-sitosterol) (Chaturvedula and Prakash, 2012;Harneti et al, 2014;Farabi et al, 2017), showed good agreement, therefore compound 2 was identified as a stigmast-5-en-3β-ol (βsitosterol), which shown in this plant for the first time. Figure 2.…”

“…Another hydroxyl group was located at C-7 based on the correlation of H-6 and H-8 to oxygenated carbon at C-7 (δ C 74.5). A comparison of the NMR data of 1 with the data for 7α-Hydroxy-β-sitosterol (Chaturvedula and Prakash, 2012;Farabi et al, 2017), revealed that the structure of the two compounds were very similar, consequently compound 1 was identified as a 7α-Hydroxy-β-sitosterol, which shown in this plant for the first time. Compound 2 was obtained as a white needlelike crystal.…”

“…The cross peak also observed at H-6/H-7/H-8 that indicated the position of double bond at C-5/C-6. The 13 C-NMR (CDCl 3 125 MHz) and HMQC and DEPT 135° spectra showed the presence of six methyl groups, one olefinic methine, one olefinic quartenary carbon, and a oxygenated methine group, resonating at δ C 71.5 (C-3) and 74.5 (C-7), indicated the characteristic of stigmastane-type steroid (Cayme and Ragasa, 2004;Farabi et al, 2017). These functionalities accounted for one of total five degree of unsaturations.…”

Xylocarpus Moluccensis Induces Cytotoxicity in Human Hepatocellular Carcinoma HepG2 Cell Line via Activation of the Extrinsic Pathway

“…Tirucallane terpenoids isolated from stems of Picrasma quassinoids exhibited Cytotoxicity against gastric cancer cell line (MKN-28) via apoptosis, by activating caspase-3 and -9. Steroids from the bark of Aglaia argentea (Meliaceae) found to be cytotoxic against P-388 murine leukemia cells (Farabi et al, 2017). Phenol-rich mangrove plant, Avicennia marina (leaf ethyl acetate) extract showed Cytotoxicity and induced apoptosis in human breast cancer (AU565 and BT483) and liver cancer cells (HepG2 and Huh7) (Huang et al, 2016).…”

Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines

“…Previous investigation reported that compounds isolated from the genus Dysoxylum exhibit diverse biological activities, which includes antitumor (Cao et al, 2013), antimicrobial (Gopalakrishnan et al, 2015), antibacterial (Hu et al, 2014b, antiparasitic (Lakhsmi et al, 2007), post-coital contraceptive (Das et al, 2013), and cytotoxic (Han et al, 2015;Ragasa et al, 2014;Kurimoto et al, 2011;Zhang et al, 2010;Ismail et al, 2009;Farabi et al, 2017).…”