Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs

Gómez‐Ruiz, Santiago; Kaluđerović, Goran N.; Prashar, Sanjiv; Polo-Cerón, Dorian; Fajardo, Mariano; Zizak, Zeljko; Sabo, Tibor J.; Juranić, Zorica D.

doi:10.1016/j.jinorgbio.2008.02.001

Cited by 61 publications

(46 citation statements)

References 102 publications

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“…Following our research on the synthesis, characterization and cytotoxic properties of metal-based anticancer drugs [47][48][49][50][51], and encouraged by the good results observed for analogous tin(IV) complexes bearing the same carboxylato ligands [48], we present the synthesis, characterization and study of the cytotoxic activity of different dimeric gallium(III) carboxylate complexes.…”

Section: Introductionmentioning

confidence: 99%

Anticancer activity of dinuclear gallium(III) carboxylate complexes

Kaluđerović

Gómez‐Ruiz

Gallego

et al. 2010

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

Anticancer activity of dinuclear gallium(III) carboxylate complexes

Kaluđerović

Gómez‐Ruiz

Gallego

et al. 2010

European Journal of Medicinal Chemistry

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“…In our first study, titanocene and ansa-titanocene compounds with different alkyl and alkenyl ligands (Figure 9 compounds 31-42) were prepared and characterized. Most of the compounds were active against all the studied cancer cell lines and the activity was dependent on the substituent at the Cp ring or at the ansa-bridge [61,62]. Of special interest were the alkenyl-substituted compounds 38, 39, and 42 which showed improved cytotoxic activity against the studied cell lines HeLa, K562, and Fem-x (Table 4).…”

Section: Titanium-based Metallodrugsmentioning

confidence: 99%

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

2017

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Abstract:For more than 100 years metal complexes have been extensively used in therapy and since the discovery of cisplatin the research in this field has expanded exponentially. The scientific community is always in search of new alternatives to platinum compounds and a wide variety of metallodrugs based on other metals have been reported with excellent therapeutic results. This short review focuses on the work that our research group has carried out since 2007 in collaboration with others and centers on the preparation of organogallium(III) compounds, organotin(IV) derivatives, and titanocene(IV) complexes together with the study of their cytotoxic anticancer properties.

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“…In general, lower activity was found in analogues where the two Cp units were bound by a two-carbon bridge, obtained as mixtures of stereoisomers (10, Scheme 3), although other ansa-metallocene complexes studied recently revealed promising activity. [45,46] Scheme 3.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Titanium(IV) Complexes: Renaissance

Tshuva

Ashenhurst

2009

Eur J Inorg Chem

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In this paper we overview our studies on amine–phenolato TiIV complexes as cytotoxic agents, in the context of the results reported thus far with titanocene dichloride, budotitane and derivatives. In particular, we emphasize the studies about the structure–activity relationship performed and important insights gained with the known compounds and our complexes, in regards to their hydrolytic behavior and cytotoxic activity, while pointing to potential mechanistic aspects. Titanocene dichloride and budotitane show cytotoxic activity towards cells that are resistant to cisplatin with reduced side effects. Their main drawback is their hydrolytic instability that has impeded mechanistic investigations and pharmaceutical use. Our new family of cytotoxic complexes was designed to include a single highly electron‐donating chelating ligand to afford octahedral TiIV complexes of relatively high hydrolytic stability, with the aim to retain ligand binding throughout the biological activity for achieving controlled processes and allowing mechanistic evaluation. The effect of several parameters on hydrolysis and cytotoxicity were investigated, including those relating to the tetradentate ligand and those relating to the labile groups. Overall we observed high cytotoxic activity that is strongly dependent on the ligand, and which is strongly correlated to the complex hydrolytic behavior. Additional mechanistic studies provide insights regarding the time frame of activity and cell penetration. Some comparisons to titanocene dichloride, budotitane and analogues are highlighted.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs

Cited by 61 publications

References 102 publications

Anticancer activity of dinuclear gallium(III) carboxylate complexes

Anticancer activity of dinuclear gallium(III) carboxylate complexes

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

Cytotoxic Titanium(IV) Complexes: Renaissance

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