Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) gene polymorphism and susceptibility to non‐Hodgkin's lymphoma

Monne, Maria; Piras, Giovanna; Palmas, Angelo; Arru, L.; Murineddu, Marco; Latte, Giancarlo; Noli, Annalisa; Gabbas, Attilio

doi:10.1002/ajh.20045

Cited by 67 publications

(50 citation statements)

References 25 publications

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“…Sun et al found it to be associated with the cancer of oesophagus and lung among the Chinese (Sun et al, 2008) and an association with gastric cancer was found by Hou et al (Hou et al, 2010). It has also been associated with non-solid tumours like non-Hodgkin's lymphoma (Monne et al, 2004). Another study found this SNP to be associated with bad lung cancer prognosis (Song et al, 2011).…”

Section: 2035 Lack Of Any Association Of the Ctla-4 +49 G/a Polymorpmentioning

confidence: 98%

Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population

Minhas¹,

Bhalla²,

Shokeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is an important protein involved in the regulation of the immune system. The +49 G/A polymorphism is the only genetic variation in the CTLA-4 gene that causes an amino acid change in the resulting protein. It is therefore the most extensively studied polymorphism among all CTLA-4 genetic variants and contributions to increasing the likelihood of developing cancer are well known in various populations, especially Asians. However, there have hiterto been no data with respect to the effect of this polymorphism on breast cancer susceptibility in our North Indian population. We therefore assayed genomic DNA of 250 breast cancer subjects and an equal number of age-, sex-and ethnicity-matched healthy controls for the CTLA-4 +49 G/A polymorphism but no significant differences in either the gene or allele frequency were found. Thus the CTLA-4 +49 G/A polymorphism may be associated with breast cancer in other Asians, but it appears to have no such effect in North Indians. The study also highlights the importance of conducting genetic association studies in different ethnic populations.

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Section: 2035 Lack Of Any Association Of the Ctla-4 +49 G/a Polymorpmentioning

confidence: 98%

Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population

Minhas¹,

Bhalla²,

Shokeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…It has been demonstrated that variations in the promoter region are likely to affect gene expression. The -318C/T (rs5742909) SNP is located in the promoter region of the CTLA-4 gene (34), and it has been suggested that this variation affects promoter activity and therefore the expression of CTLA-4 on the cell surface (35). Carriers of the T allele showed a marked enhancement of CTLA-4 mRNA expression and consequently, more expression of CTLA-4 protein on the cell surface (7).…”

Section: Snpmentioning

confidence: 99%

Association of CTLA-4 gene polymorphisms −318C/T and +49A/G and Hashimoto's thyroidits in Zahedan, Iran

et al. 2016

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Abstract.Hashimoto's thyroiditis (HT) is a chronic inflammation of the thyroid gland and is known as the most common autoimmune disease. Development of autoimmune destruction of thyroid cells is a multi-step process involving convergence of genetic and environmental factors. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) has an important role in homeostasis and negative regulation of immune responses, and is therefore considered to be a key element in the development of autoimmune diseases. The present study evaluated the association of the CTLA-4 gene polymorphisms 318C/T (rs5742909) and +49A/G (rs231775) with HT in an Iranian population (including 82 patients with HT and 104 healthy controls who were referred for routine premarital blood screenings). Genotyping was performed using the tetra-primer amplification refractory mutation system polymerase chain reaction technique. No significant differences were observed in genotype and allele frequencies in the single nucleotide polymorphisms (SNPs) between cases and controls. In the cases as well as in the controls, the TT genotype in the -318C/T polymorphism was absent and the predominant genotype was CC, while the predominant genotype for the +49A/G SNP was AA. As only few studies in this field have assessed Iranian and even Middle Eastern populations, additional studies with a higher number of samples are recommended to further assess the impact of -318C/T (rs5742909) and +49A/G (rs231775) polymorphisms of CTLA-4 on HT.

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“…The results of the study conducted by Lieu et al 6 showed that rs231775 polymorphism of CTLA-4 was associated with osteosarcoma risk (GG vs Allele A and genotype AA of the CTLA-4 gene+49A/G polymorphism were defined as the risk factors for cancer. The findings of Monne et al 19 indicate that the genotype and haplotype analysis showed the exon 1+49 AA genotype was over-represented among patients with Non-Hodgkin's Lymphoma (NHL). Farbod et al 8 investigated the potential influences of cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphisms on breast cancer risk, the distribution of CTLA-4 single nucleotide polymorphisms (1661AG) in breast cancer patients and controls.…”

Section: Discussionmentioning

confidence: 99%

CTLA-4 Gene +49 A/G Polymorphism in Prostate Cancer Patients in Turkish Population

Diler¹

2017

ACP

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Background: Cytotoxic T-lymphocyte antigen 4 (CTLA-4), the T cell surface antigen is expressed during activation. Prostate cancer (PCa) is one of the most common cancers in Western population and its rate is increasing in the Eastern World. The aim of this study was to evaluate cytotoxic T lymphocyte associated antigen-4 (CTLA-4) gene+49A/G polymorphisms in prostate cancer patients. Material and methods:This study included 119 (mean age: 68.94±8.38 years) healthy controls and 62 (mean age: 72.83±7.60 years) patients with prostate cancer. The CTLA-4 gene+49A/G (rs231775) gene regions were amplified using polymerase chain reaction (PCR), detected by restriction fragment length polymorphism (RFLP).

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Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) gene polymorphism and susceptibility to non‐Hodgkin's lymphoma

Cited by 67 publications

References 25 publications

Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population

Lack of any Association of the CTLA-4 +49 G/A Polymorphism with Breast Cancer Risk in a North Indian Population

Association of CTLA-4 gene polymorphisms −318C/T and +49A/G and Hashimoto's thyroidits in Zahedan, Iran

CTLA-4 Gene +49 A/G Polymorphism in Prostate Cancer Patients in Turkish Population

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