Cytotoxic Tetrahydroxanthone Dimers from the Mangrove-Associated Fungus Aspergillus versicolor HDN1009

Yu, Ge; Wu, Guangwei; Sun, Zichao; Zhang, Xiaomin; Che, Qian; Gu, Qianqun; Zhu, Tianjiao; Li, Dehai; Zhang, Guojian

doi:10.3390/md16090335

Cited by 36 publications

(40 citation statements)

References 11 publications

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“…Semi-preparative HPLC (YMC Co., Ltd., Kyoto, Japan) was performed on an ODS column (YMC-Pack ODS-A, 10 × 250 mm, 5 μm, 3 mL/min). Medium-pressure liquid chromatography (MPLC) was performed on a Bona-Agela CHEETAHTM HP100 (Beijing Agela Technologies Co., Ltd., Beijing, China) [26].…”

Section: Methodsmentioning

confidence: 99%

Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11

Han

Zhang

et al. 2019

Marine Drugs

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Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinolide (1) and 10,11,16,17-tetrahydrobislongiquinolide (2), as well as four known analogues, bislongiquinolide (3), 16,17-dihydrobislongiquinolide (4), sohirnone A (5), and 2′,3′-dihydrosorbicillin (6). The results support that the global regulator LaeA is a useful tool in activating silent gene clusters in Penicillium strains to obtain previously undiscovered compounds.

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Section: Methodsmentioning

confidence: 99%

Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11

Han

Zhang

et al. 2019

Marine Drugs

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“…Then it has antidiabetic activity by preventing the reducing the impact of carbohydrates in blood ( Figure 7 b). Three novel compounds 204 , 205 and 206 were obtained from the fungus A. versicolor HDN1009 ( Figure 7 b) [ 120 ]. Structure 204 was showed hopeful antibacterial activities towards both G-positive and G-negatie bacteria .…”

Section: Main Textmentioning

confidence: 99%

Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration

El-Bondkly

2021

Heliyon

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The growing threat arises due to diseases such as cancer and the infections around the world leading to a critical requirement for novel and constructive compounds with unique ways of action capable of combating these deadly diseases. At present, it is evident that endophytic fungi constitute an enormous as well as comparatively untapped source of great biodiversity that can be considered as a wellspring of effective novel natural products for medical, agricultural and industrial use. Marine endophytic fungi have been found in every marine plants (algae, seagrass, driftwood, mangrove plants), marine vertebrates (mainly, fish) or marine invertebrates (mainly, sponge and coral) inter- and intra-cellular without causing any palpable symptoms of illness. Since evolution of microbes and eukaryotes to a higher level, coevolution has resulted in specific interaction mechanisms. Endophytic fungi are known to influence the life cycle and are necessary for the homeostasis of their eukaryotic hosts and the chemical signals of their host have been shown to activate gene expression in endophytes to induce expression of endophytic secondary metabolites. Marine endophytic fungi are receiving increasing attention by chemists because of their varied and structurally unmatched compounds that have strong biological roles in life as lead pharmaceutical compounds, including anticancer, antiviral, insulin mimetic, antineurodegenerative, antimicrobial, antioxidant and immuno-suppressant compounds. Moreover, fungal endophytes proved to have different biological activities for exploitation in the environmental and agricultural sustainability.

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“…Aspergillus versicolor , a slow-growing filamentous fungus, normally are found in air, soil, marine sediment, corrupted plants, and agricultural products. Previous chemical investigations on the fungus Aspergillus versicolor from different environments have resulted in the identification of new secondary metabolites with a variety of structures, such as alkaloids [4,5,6,7,8,9], anthraquinones [10,11,12,13,14], xanthones [15,16,17,18,19], diphenyl ethers [20,21], lactones [22,23,24,25,26], peptides [27], polyketide [28], terpenoids [29,30], and varicuothiols [31].…”

Section: Introductionmentioning

confidence: 99%

New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

Gao

et al. 2019

Marine Drugs

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Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-1), (±)-8-hydroxy-brevianamide R ((±)-2), and (±)-8-epihydroxy-brevianamide R ((±)-3), together with four known compounds, (±)-brevianamide R ((±)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guérin. Compounds 1–4 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus.

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Cytotoxic Tetrahydroxanthone Dimers from the Mangrove-Associated Fungus Aspergillus versicolor HDN1009

Cited by 36 publications

References 11 publications

Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11

Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11

Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration

New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

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