Cytotoxic Thiocarbamate Derivatives of Boldine

Thomet, Franz A.; Pinyol, Pablo; Villena, Joan; Espinoza, Luis; Reveco, Patricio G.

doi:10.1177/1934578x1000501015

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Further, the antiproliferative properties of boldine are improved by the synthesis of different derivatives. Two new compounds -3thiocarbamateboldine and 2,9-O,O-diacetyl-3-thiocarbamateboldine -were synthesized and their cytotoxicity evaluated by Thomet et al [23]. The derivatization of boldine to a diphenylphosphinyl derivative results in its enhanced lipophilicity as well as an increase in its intercalating behavior and thus in significant cytotoxic activity in breast cancer cells lines (MDA-MB-231 and MCF-7).…”

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Boldine and Related Aporphines: From Antioxidant to Antiproliferative Properties

Muthná

Ćmielová

Tomšík

et al. 2013

Natural Product Communications

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Plant and folk medicine represent nowadays a source of either new therapeutic substances or substrates for drug synthesis. One such promising group for possible further exploitation is the family of aporphine alkaloids containing boldine and related compounds. In this mini-review we focus on boldine and its newly described effects, which predominantly arise from its antioxidant properties. Moreover, we try to compare its antiproliferative properties with other better known members of the aporphine group.

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confidence: 99%

Boldine and Related Aporphines: From Antioxidant to Antiproliferative Properties

Muthná

Ćmielová

Tomšík

et al. 2013

Natural Product Communications

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show abstract

“…7 Many o-oxygen substituted aryl sulfides have been synthesized via aryne insertion into the SvO bond of sulfoxides. Two or more substituted o-alkylthio aryl esters are the important structural units in biologically active molecules and medicines, such as cox-2 inhibitors, 8 boldine, 9 and antimetabolites 10 (Scheme 1a). Therefore, an efficient strategy is desirable to be developed for the C-O/C-S difunctionalization of fused highly substituted benzene derivatives.…”

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confidence: 99%