Cytotoxic Tph-like cells are involved in persistent tissue damage in IgG4-related disease

Yabe, Hayato; Kamekura, Ryuta; Yamamoto, Motohisa; Murayama, Kosuke; Kamiya, Shiori; Ikegami, Ippei; Shigehara, Katsunori; Takaki, Haruyuki; Chiba, Hirofumi; Takahashi, Hiroki; Takano, Kenichi; Ichimiya, Shingo

doi:10.1080/14397595.2020.1719576

Cited by 23 publications

(30 citation statements)

References 45 publications

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“…An increase in circulating Tph cells has also been observed in other autoimmune and inflammatory diseases, such as Sjögren’s syndrome, 32 IgG4-related diseases (IgG4-RDs), 33 , 34 systemic sclerosis, 35 IgA nephropathy 36 and type I diabetes. 37 Some correlations were observed between the frequency of circulating Tph cells and disease activity and/or clinical parameters in these diseases.…”

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 90%

“…30 Whereas previous studies indicated that these SLE parameters were highly correlated with the frequency of cTfh cells, 31 other studies indicated an even higher correlation with cTph cells than cTfh cells. 29 An increase in circulating Tph cells has also been observed in other autoimmune and inflammatory diseases, such as Sjögren's syndrome, 32 IgG4-related diseases (IgG4-RDs), 33,34 systemic sclerosis, 35 IgA nephropathy 36 and type I diabetes. 37 Some correlations were observed between the frequency of circulating Tph cells and disease activity and/or clinical parameters in these diseases.…”

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 95%

“…For example, CX3CR1 + cTph cells in IgG4-RD seem to be cytotoxic cells, as indicated by the high expression of cytotoxic molecules, including GZMA, PRF1, and GPR56. 34 Similarly, the phenotype, gene profile, and function of cTph cells differs among diseases, most likely as a reflection of differences in the microenvironment of inflamed tissues. Type I IFN plays a key pathogenic role in SLE, and accordingly, IFNinducible genes are highly enriched in cTph cells from SLE patients.…”

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 99%

“… 37 Some correlations were observed between the frequency of circulating Tph cells and disease activity and/or clinical parameters in these diseases. For example, the frequency of cTfh cells is positively correlated with serum IgG4 levels and the number of involved organs in IgG4-RDs 33 , 34 and negatively correlated in IgA nephropathy with the estimated glomerular filtration rate. 36 In children with type 1 diabetes, an increase in cTph cells highly evident in patients who were positive for multiple autoantibodies.…”

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 99%

“…For example, CX3CR1 + cTph cells in IgG4-RD seem to be cytotoxic cells, as indicated by the high expression of cytotoxic molecules, including GZMA, PRF1, and GPR56. 34 …”

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 99%

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Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases

2020

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The interactions of CD4 + T cells and B cells are fundamental for the generation of protective antibody responses, as well as for the development of harmful autoimmune diseases. Recent studies of human tissues and blood samples have established a new subset of CD4 + B helper T cells named peripheral helper T (Tph) cells. Unlike T follicular helper (Tfh) cells, which interact with B cells within lymphoid organs, Tph cells provide help to B cells within inflamed tissues. Tph cells share many B helper-associated functions with Tfh cells and induce B cell differentiation toward antibody-producing cells. The differentiation mechanism is also partly shared between Tph and Tfh cells in humans, and both Tfh and Tph cells can be found within the same tissues, including cancer tissues. However, Tph cells display features distinct from those of Tfh cells, such as the expression of chemokine receptors associated with Tph cell localization within inflamed tissues and a low Bcl-6/Blimp1 ratio. Unlike that of Tfh cells, current evidence shows that the target of Tph cells is limited to memory B cells. In this review, we first summarize recent findings on human Tph cells and discuss how Tph and Tfh cells play shared and distinct roles in human diseases.

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Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 90%

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 95%

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 99%

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 99%

“…For example, CX3CR1 + cTph cells in IgG4-RD seem to be cytotoxic cells, as indicated by the high expression of cytotoxic molecules, including GZMA, PRF1, and GPR56. 34 …”

Section: Circulating Tph Cells In Autoimmune Diseasesmentioning

confidence: 99%

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