Cytotoxic triterpenoid saponins from the fruits of Aesculus pavia L.

Zhang, Zhizhen; Li, Shiyou

doi:10.1016/j.phytochem.2007.05.020

Cited by 49 publications

(37 citation statements)

References 10 publications

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“…The anticancer activities of terpenoids, saponins, cardiac glycosides and anthraquinones have been reported for various plant extracts [10,18,19]. Terpenoids and saponins are biologically active against various human cancer cell lines [19].…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical Screening and Cytotoxicity of Crude Extracts of <i>Vatica diospyroides</i> Symington Type LS

Srisawat¹,

Chumkaew²,

Heed-Chim³

et al. 2013

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

“…Terpenoids and saponins are biologically active against various human cancer cell lines [19]. Similarly, these compounds are potent against human breast cancer cell lines.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Cytotoxicity of Crude Extracts of <i>Vatica diospyroides</i> Symington Type LS

Srisawat¹,

Chumkaew²,

Heed-Chim³

et al. 2013

Trop. J. Pharm Res

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“…Later, however, in addition to these compounds, we isolated 13 new additional similar compounds from another tree grown in the same location (Fig. 7) [119]. This tree had the same seed source with the above plant (previously was told from different provenance) but the terminal shoots were severely damaged by fruit collection in the previous year.…”

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 98%

“…Decapitation pruning can also significantly induce biosynthesis of some alkaloids and triterpenoid glycosides that are not detected or occur at too low a level to be isolated in untreated plants [118][119][120][121]. Camptotheca acuminata is one of the most extensively studied species.…”

Section: Induced Derivatization Of Target Compoundsmentioning

confidence: 99%

Trichome Management to Enhance Camptothecins in Camptotheca Decaisne

Li¹,

Zhang²,

Wang³

et al. 2014

TOPHARMCJ

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Inducible chemical defenses of plants have received much attention in the last three decades, and these defenses often involve trichomes. It is known that some plant secondary metabolites may accumulate in trichomes which can protect plants from damage by herbivores. However, studies on plant trichomes are largely limited to some major vegetable or cash crops and model species with large glandular trichomes (e.g., Nictotiana and Arabidopsis). In fact, the existing studies on the effect of damage (pruning or defoliation) on trichome density or chemical production in plants are partial and even contradictory. Management strategies to maximize chemical induction in medicinal plants or pharmaceutical crops have not been developed well. Our experiments showed that camptothecins (CPTs) are primarily accumulated in glandular trichomes in Camptotheca. We found that pruning, particularly decapitation pruning (T-pruning) can effectively induce contents and derivatization of CPTs in Camptotheca, and the leveled CPTs caused induced endogenous autotoxicity (abnormal morphogenesis) in the plants. Auxin reduction is a trigging factor for such induced biosynthesis and endogenous autotoxicity. Because trichomes are visible to the naked eye and can be much more easily targeted and measured than CPTs, the term "Trichome Management" is used for strategy development to induce CPTs in Camptotheca.

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“…Desmodium Desmodium adscendens (McManus et al, 1993;Rastogi et al, 2011) Triterpenoid saponins Fabaceae Glycine Soybeans (Glycine max) (Francis, Kerem et al 2002, De Geyter, Lambert et al 2007 (Yoshikawa et al, 1996;Kimura et al, 2006;Zhang et al, 2006;Zhang and Li, 2007;Kimura et al, 2008) (El Izzi et al, 1992;Massiot et al, 1992b) Triterpenoid saponins Lecythidaceae Barringtonia Barringtonia acutangula (Pal et al, 1994) Monodesmosidic glucuronide saponins; Barringtosides A, B and C…”

Section: Fabaceaementioning

confidence: 99%

Role of Saponins in Plant Defense against the Diamondback Moth, Plutella xylostella (L.)

Hussain¹,

Qasim²,

Bamisile³

et al. 2017

Preprint

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Abstract:The diamondback moth (DBM), Plutella xylostella L. (Lepidoptera: Plutellidae) is very destructive crucifers specialized pest that has resulted in significant crop losses worldwide. The pest is well attracted to glucosinolate-containing crucifers such as; Barbarea vulgaris (Brassicaceae), and generally to other plants in the genus Barbarea. B. vulgaris on their part, build up resistance against DBM and other herbivorous insects using glucosinolates; that are plant secondary metabolites used in plant defense-contained only in plants of the order Brassicales. Aside glucosinolates, plants in this genus Barbarea (Brassicaceae) also contain saponins; which is toxic to insects and act as feeding deterrents for plant herbivores, most importantly, DBM, as it was found to prevent the survival of DBM larvae on the plant. Saponins are plant secondary metabolites have been established in higher concentrations in younger in contrast to older leaves within the same plant. Previous studies have found a relationship between ontogenetical changes in the host plant's saponin content and attraction/resistance to P. xylostella. The younger leaves recorded higher concentrations of glucosinolates and saponins, which naturally attracts the plant herbivores. DBM was reported to have evolved mechanisms to avoid the toxicity of the former. The plant-herbivore had adapted glucosinolates for host plant recognition, feeding and oviposition stimulants. Despite the adaptation for oviposition by P. xylostella adults, larvae of the insect cannot survive on the same plant. An example is in some varieties of B. vulgaris. The triterpenoid saponins which act as feeding deterrents in larvae are responsible for this direct defense mechanism against P. xylostella. In the future, trials by plant breeders could aim at transferring this insect resistance to other crops. The previous trials had limited because of lack of knowledge on the biosynthetic pathways and regulatory networks of saponins. Herein, we discussed exclusively; saponins mediated plant defense mechanisms against the DBM.

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Cytotoxic triterpenoid saponins from the fruits of Aesculus pavia L.

Cited by 49 publications

References 10 publications

Phytochemical Screening and Cytotoxicity of Crude Extracts of <i>Vatica diospyroides</i> Symington Type LS

Phytochemical Screening and Cytotoxicity of Crude Extracts of <i>Vatica diospyroides</i> Symington Type LS

Trichome Management to Enhance Camptothecins in Camptotheca Decaisne

Role of Saponins in Plant Defense against the Diamondback Moth, Plutella xylostella (L.)

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