Cytotoxic triterpenoids from Ganoderma lucidum

Cheng, Chun‐Ru; Yue, Qing-Xi; Wu, Zhiyuan; Song, Xiao-Yi; Tao, Sijia; Wu, Xiaohui; Xu, Pingping; Li, Xuan; Guan, Shu‐Hong; Guo, De‐An

doi:10.1016/j.phytochem.2010.06.005

Cited by 117 publications

(63 citation statements)

References 34 publications

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“…41) In addition, GAs and other active components have distinct cytotoxicity against a broad spectrum of cancer cell lines, including hematoma cell lines HepG2, HepG2,2,15, p-388, and HuH-7, colorectal carcinoma HCT-116, Burkitt's lymphoma Raji cells, leukemia HL-60 cells, and oral epidermoid carcinoma KB cells. 12,[42][43][44] In the present study we found that culture extracts prepared from G. lucidum were highly toxic to human lung cancer cells CH27, oral cancer cells HSC-3, and skin cancer cells M21, confirming the broad pharmacological activities of G. lucidum. Thus, PDA supports greater production and accumulation of GAs and many other active substances in G. lucidum.…”

Section: Discussionsupporting

confidence: 76%

Enhanced Production of Ganoderic Acids and Cytotoxicity ofGanoderma lucidumUsing Solid-Medium Culture

You

Lee

Chung

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionsupporting

confidence: 76%

Enhanced Production of Ganoderic Acids and Cytotoxicity ofGanoderma lucidumUsing Solid-Medium Culture

You

Lee

Chung

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…lucidum (dried fruit bodies) [31] 92 12β-Acetoxy-7β-hydroxy-3,11,15,23-tetraoxo-5α-lanosta-8,20-dien-26-oic acid G. lucidum [26] 93 Ganoderenic acid F (3,7,11,15,23-pentaoxo-5α-lanosta-8,20E-dien-26-oic acid)…”

Section: -O-methylganoderic Acid O ((22s 24e)-3α L5α 22-triacetoxmentioning

confidence: 99%

A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

et al. 2014

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Ganoderma triterpenes (GTs) are the major secondary metabolites of Ganoderma lucidum, a traditional Chinese medicine, popularly used for complementary cancer therapy. GTs are lanostane-tetracyclic triterpenes. They have been reported to possess anti-tumor, anti-inflammation, antioxidant, antimicrobial and blood fat reducing effects. To date, 316 GTs have been found and their similar chemical structures have proved difficult to elucidate. This paper compiles 316 naturally occurring triterpenes from Ganoderma based on the literature published through January 2013 along with their structures, physiological activities and 13 C-NMR spectral data.

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“…Ganoderic acid D and the reference compounds (ganoderic acid B and ganoderic acid E) were isolated from the fruiting bodies of G. lucidum. Their chemical structures were unambiguously identified by the comparison of their NMR and MS spectra data with those reported in the literature (Kubota et al, 1982;Kikuchi et al, 1985;Kohda et al, 1985;Cheng et al, 2010). Their purities were more than 98% as determined by highperformance/UV analysis.…”

Section: Methodsmentioning

confidence: 90%

Identification of Metabolites of Ganoderic Acid D by Ultra-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

Cheng

Yang

et al. 2012

Drug Metab Dispos

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ABSTRACT:Ganoderic acid D (GD) is the major active triterpenoid in Ganoderma lucidum, a medicinal fungus used daily. However, the metabolic fate of GD remains unknown. To know whether GD is extensively metabolized, we first investigated the metabolism of GD in vitro and in vivo. The metabolic profiles of the bile samples obtained from rats in vivo were almost the same as those obtained in vitro. Using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry, a total of 25 metabolites were identified from the bile sample. Few metabolites were found in the urine samples. These results indicated that biliary rather than renal clearance was the major route of excretion. The major metabolites were identified by comparison with the standard reference compounds. Metabolites at low concentrations were identified by interpreting the mass spectra. Both phase I and phase II metabolites were observed. The metabolic transformation included reduction, monohydroxylation, dihydroxylation, trihydroxylation, oxidation, desaturation, sulfation, and glucuronidation. The main metabolic soft spots in the chemical structure of GD were the 3-carbonyl group, angular methyl groups, the 7-hydroxy group, and the 26-carboxylic acid moiety. Overall, this study gives us an insight into the metabolism of GD, an active oxygenated tetracyclic triterpenoid.

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Cytotoxic triterpenoids from Ganoderma lucidum

Cited by 117 publications

References 34 publications

Enhanced Production of Ganoderic Acids and Cytotoxicity ofGanoderma lucidumUsing Solid-Medium Culture

Enhanced Production of Ganoderic Acids and Cytotoxicity ofGanoderma lucidumUsing Solid-Medium Culture

A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids from Ganoderma spp.

Identification of Metabolites of Ganoderic Acid D by Ultra-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

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