1996
DOI: 10.1006/taap.1996.0215
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Cytotoxicity, Accumulation, and Efflux of Cisplatin and Its Metabolites in Human Ovarian Carcinoma Cells

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Cited by 19 publications
(13 citation statements)
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“…Pereira-Maia and GarnierSuillerot demonstrated that, in cultured cells, aquated forms of cisplatin accumulate more rapidly in comparison to the dichloro derivative [14]. We and others found a relationship between the intracellular Pt concentration and cell growth inhibition [14] [15], but other studies did not confirm this relationship [16]. In the present work, we have found that equal intracellular concentrations of Pd led to a similar cytotoxic effect.…”
supporting
confidence: 78%
“…Pereira-Maia and GarnierSuillerot demonstrated that, in cultured cells, aquated forms of cisplatin accumulate more rapidly in comparison to the dichloro derivative [14]. We and others found a relationship between the intracellular Pt concentration and cell growth inhibition [14] [15], but other studies did not confirm this relationship [16]. In the present work, we have found that equal intracellular concentrations of Pd led to a similar cytotoxic effect.…”
supporting
confidence: 78%
“…cis-Diamminedichloroplatinum (II) (CDDP) or cisplatin is one of the most effective chemotherapeutic agents used for the treatment of ovary, lung, testicle, head, and neck carcinoma (1)(2)(3)(4)(5). However, its use presents some inconveniences, such as development of resistance in human ovarian cell line A2780, cervical cancer cell line ME180 and colon carcinoma cell line LoVo; side effects, principally nephrotoxicity, and chemical incompatibility with other drugs used simultaneously in polychemotherapy, such as etoposide and thiotepa (6,7).…”
Section: Introductionmentioning
confidence: 99%
“…Cisplatin is also spontaneously hydrolyzed Miller and House 1989a, b , 1990Ehrsson et al 1995 ). In contrast to other types of biotransformations, hydrolysis constitutes an activation pathway of cisplatin (Shirazi et al 1996 ;Daley-Yates and McBrien 1984 ;Litterst 1981 ;Ekborn et al 2003a , b ;Yachnin et al 1998 ). The hydrolysis is suppressed by a high chloride concentration, and increasing the sodium chloride concentration of the cisplatin vehicle decreases the toxicity in cisplatin-treated animals (Litterst 1981 ;Daley-Yates and McBrien 1985 ), indicating the signifi cance of hydrolysis of cisplatin in vivo.…”
Section: Inner Ear Pharmacokineticsmentioning
confidence: 96%
“…Cisplatin is easily subjected to ligandexchange reactions with nucleophiles, resulting in platinum complexes with e.g., albumin (Gullo et al 1980 ), globulin (Gullo et al 1980 ), cysteine (Andrews et al 1984 ), glutathione (GSH) (Andrews et al 1984 ), and methionine (Andrews et al 1984 ). These biotransformation products are generally less active than the parent compound (Andrews et al 1984 ;Daley-Yates and McBrien 1984 ;Dedon and Borch 1987 ;Muldoon et al 2001 ;Shirazi et al 1996 ). Cisplatin is also spontaneously hydrolyzed Miller and House 1989a, b , 1990Ehrsson et al 1995 ).…”
Section: Inner Ear Pharmacokineticsmentioning
confidence: 97%
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