Cytotoxicity and Antimicrobial Activity ofNerium oleanderExtracts

Sawi, Nagwa M. El; Geweely, Neveen S.; Qusti, Safaa; Mohamed, Mervat S.; Kamel, Amr

doi:10.1080/09712119.2010.9707089

Cited by 23 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nerium oleander (common oleander) is potentially lethal plant after ingestion for human beings, all parts of this plant are toxic (Bandara et al, 2010). It has antimicrobial properties (Huq et al, 1999;El Sawi et al, 2010), antioxidant activity (Mohadjerani, 2012) and also insecticide effect (Bagari et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Assessment of toxicity on the basis of total phenolic content in oleander leaves (Nerium oleander L.) against Myzus persicae (Sulzer, 1776) (Hemiptera: Aphididae)

Nia

Frah

Lekbir

et al. 2018

AAS

View full text Add to dashboard Cite

Nerium oleander is an evergreen flowering shrub or small tree distributed widely in the Mediterranean region. It is also a source of polyphenols and cardenolides ?? with insecticidal effect which could be a safe alternative of chemical control of insect pests. In the present work, five concentrations (0 %, 1 %, 2.5 %, 5 %, and 10 %) of ethanolic extract from Nerium oleander leaves were evaluated for its insecticidal effect against 3 to 4 days old Myzus persicae individuals under laboratory conditions. Obtained results showed a significant insecticidal effect with 70 % of mortality at the highest concentration (10 %). Total phenolic content of leaf ethanolic extract of this plant was 1721.36 mg gallic acid equivalent 100 g-1 dry matter. The results obtained suggest that we could make bioinsecticides based on leaves ethanolic extracts from N. oleander which rich in polyphenols for use eventually in integrated pest management.

show abstract

Section: Resultsmentioning

confidence: 99%

Assessment of toxicity on the basis of total phenolic content in oleander leaves (Nerium oleander L.) against Myzus persicae (Sulzer, 1776) (Hemiptera: Aphididae)

Nia

Frah

Lekbir

et al. 2018

AAS

View full text Add to dashboard Cite

show abstract

“…Nerium oleander (Oleander) is one of the most poisonous dwarf evergreen shrubs in the world 58 . Extracts from various parts of the plant show also anti-cancer 59 , 60 , anti-microbial 61 , anti-inflammatory 62 , anti-diabetic 63 , and neuroprotective activities 62 . Common ingredients of Oleander extract include polysaccharides containing rhamnose, galactose, arabinose, mannose, glucose, and galacturonic acid 64 – 67 .…”

Section: Introductionmentioning

confidence: 99%

DNA-damage and cell cycle arrest initiated anti-cancer potency of super tiny carbon dots on MCF7 cell line

Şimşek

Şüküroğlu

Yetkin

et al. 2020

Sci Rep

View full text Add to dashboard Cite

While carbon-based materials have spearheaded numerous breakthroughs in biomedicine, they also have procreated many logical concerns on their overall toxicity. carbon dots (cDs) as a respectively new member have been extensively explored in nucleus directed delivery and bioimaging due to their intrinsic fluorescence properties coupled with their small size and surface properties. Although various in vitro/in vivo studies have shown that CDs are mostly biocompatible, sufficient information is lacking regarding genotoxicity of them and underlying mechanisms. This study aims to analyze the real-time cytotoxicity of super tiny CDs (2.05 ± 0.22 nm) on human breast cancer cells (MCF7) and human primary dermal fibroblast cell cultures (HDFa) by xCELLigence analysis system for further evaluating their genotoxicity and clastogenicity to evaluate the anti-tumor potential of cDs on breast adenocarcinoma. As combined with flow cytometry studies, comet assay and cytokinesisblock micronucleus assay suggest that the CDs can penetrate to the cell nuclei, interact with the genetic material, and explode DNA damage and G0/G1 phase arrest in cancer cells even at very low concentrations (0.025 ppm) which provide a strong foundation for the design of potentially promising cD-based functional nanomaterials for DnA-damage induced treatment in cancer therapy. Functional nanomaterials that can better target cancer cells that will improve prevention and therapy could be accomplished by the combined efforts of nanotoxicologists, cancer biologists and nanobiomaterial scientists focused on toxicology and related cancer therapy. Engineering carbon-based nanomaterials and their applications are among the most dynamic fields in modern advanced materials science and engineering 1-3. To date, various carbon nanomaterials such as carbon nanotubes 4,5 , fullerenes 6 , graphene 7,8 , graphene oxides 9 , carbon diamonds 10,11 , and carbon dots 12,13 have been synthesized and reported by various researchers. Among these, CDs have become particularly interesting because of their unique physical and chemical properties such as thermal and electrical conductivity, high mechanical strength together with their unique optic and fluorescence features 14-16. They have been used in bio-imaging, drug delivery, nucleus targeting, and labeling, photodynamic therapy, optoelectronics, solar cells, photocatalyst design, photodetectors, and many other biological and engineering fields 17-26. Several methods are available for the synthesis of CDs, namely, laser ablation 15 , electro-oxidation 27 or oxidative acid treatment 12 ; while nowadays, less laborsome and cheaper methods such as hydrothermal 28 and thermal synthesis 24,29,30 , microwave-assisted hydrothermal synthesis 31 , ultrasound synthesis 32 , etc. are popularly exercised. CDs can be synthesized either from inorganic materials 19,33 such as graphene 34 , carbon black 35 , and candle soot 12

show abstract

“…Indeed, there are huge amounts of agricultural wastes that are produced on a daily basis. Nerium oleander plant, having a wide geographical distribution, has attracted the attention of researchers due to its use in various applications [16][17][18]. The fruits of Nerium are narrow capsules with a length of 5-23 cm.…”

Section: Introductionmentioning

confidence: 99%

A Cellulosic Fruit Derived from Nerium oleander Biomaterial: Chemical Characterization and Its Valuable Use in the Biosorption of Methylene Blue in a Batch Mode

et al. 2020

View full text Add to dashboard Cite

Cellulose substrate waste has demonstrated great potential as a biosorbent of pollutants from contaminated water. In this study, Neriumoleander fruit, an agricultural waste biomaterial, was used for the biosorption of methylene blue from synthetic solution. Fourier-transform infrared (FTIR) spectroscopy indicated the presence of the main absorption peak characteristics of cellulose, hemicellulose, and lignin compositions. X-ray diffraction (XRD) pattern exhibited peaks at 2θ = 14.9° and 2θ = 22°, which are characteristics of cellulose I. Scanning electron microscopy (SEM) showed a rough and heterogeneous surface intercepted by some cavities. Thermogravimetric analysis (TGA) showed more than a thermal decomposition point, suggesting that Nerium fruit is composed of cellulose and noncellulosic matters. The pHpzc value of Nerium surface was experimentally determined to be 6.2. Nerium dosage, pH, contact time, dye concentration, and temperature significantly affected the adsorption capacity. The adsorption capacity reached 259 mg/g at 19 °C. The mean free energy ranged from 74.53 to 84.52 KJ mol−1, suggesting a chemisorption process. Thermodynamic parameters define a chemical, exothermic, and nonspontaneous mechanism. The above data suggest that Nerium fruit can be used as an excellent biomaterial for practical purification of water without the need to impart chemical functionalization on its surface.

show abstract

Cytotoxicity and Antimicrobial Activity ofNerium oleanderExtracts

Cited by 23 publications

References 21 publications

Assessment of toxicity on the basis of total phenolic content in oleander leaves (Nerium oleander L.) against Myzus persicae (Sulzer, 1776) (Hemiptera: Aphididae)

Assessment of toxicity on the basis of total phenolic content in oleander leaves (Nerium oleander L.) against Myzus persicae (Sulzer, 1776) (Hemiptera: Aphididae)

DNA-damage and cell cycle arrest initiated anti-cancer potency of super tiny carbon dots on MCF7 cell line

A Cellulosic Fruit Derived from Nerium oleander Biomaterial: Chemical Characterization and Its Valuable Use in the Biosorption of Methylene Blue in a Batch Mode

Contact Info

Product

Resources

About