Secondary Metabolites - Trends and Reviews 2022
DOI: 10.5772/intechopen.102223
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Cytotoxicity and Antitumor Action of Lignans and Neolignans

Abstract: Lignans and neolignans are plant’s secondary metabolites, widely distributed in the plant kingdom, and have been identified in more than 70 plant families. These compounds are mainly localized in lignified tissues, seeds, and roots. Lignans and neolignans present a great variety of biological activities, such as antioxidant, anti-inflammatory, antineurodegenerative, antiviral, antimicrobial, and antitumor. By 2040, it is estimated that the number of new cancer cases per year will rise to 29.5 million; therefor… Show more

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“…To ensure the production of a standardized extract and verify the reproducibility of the extraction method and its associated biological effects, the main compounds in the CCM extract were identified as (+)-isolariciresinol ( 6 ), dehydrodiconiferyl alcohol-9- O -β- d -glucopyranoside ( 7 ), and americanol A ( 10 ), and quantified via HPLC-DAD analysis. The cytotoxic activity of the same or structurally related lignans and neolignans on a wide range of cell lines is reported in the literature [ 43 , 44 , 45 , 46 ]. (+)-isolariciresinol and dihydrodehydrodiconiferyl alcohol-9- O -β- d -glucopyranoside resulted to be cytotoxic against oral adenosquamous, hepatoma, ovarian and colorectal carcinoma, and breast and lung adenocarcinoma cells with IC 50 values ranging from 57.8 to 95.18 μg/mL.…”
Section: Discussionmentioning
confidence: 99%
“…To ensure the production of a standardized extract and verify the reproducibility of the extraction method and its associated biological effects, the main compounds in the CCM extract were identified as (+)-isolariciresinol ( 6 ), dehydrodiconiferyl alcohol-9- O -β- d -glucopyranoside ( 7 ), and americanol A ( 10 ), and quantified via HPLC-DAD analysis. The cytotoxic activity of the same or structurally related lignans and neolignans on a wide range of cell lines is reported in the literature [ 43 , 44 , 45 , 46 ]. (+)-isolariciresinol and dihydrodehydrodiconiferyl alcohol-9- O -β- d -glucopyranoside resulted to be cytotoxic against oral adenosquamous, hepatoma, ovarian and colorectal carcinoma, and breast and lung adenocarcinoma cells with IC 50 values ranging from 57.8 to 95.18 μg/mL.…”
Section: Discussionmentioning
confidence: 99%