Cytotoxicity and DNA interaction of brucine and strychnine—Two alkaloids of semen strychni

Liu, Fei; Wang, Xiaolin; Han, Xu; Tan, Xin; Kang, Weijun

doi:10.1016/j.ijbiomac.2015.03.017

Cited by 33 publications

(9 citation statements)

References 30 publications

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“…The route of administration also had a significant effect on the toxicity of brucine. In addition, it was found that the cytotoxicity of brucine was related to time and concentration, and brucine could be inserted into DNA double helix structure to interfere with DNA sequence (Liu et al, 2015).…”

Section: Toxicitymentioning

confidence: 99%

Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology

Huang

et al. 2020

Front. Pharmacol.

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Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents of Nux-vomica. Modern pharmacology studies and clinical practice demonstrate that brucine possesses wide pharmacological activities, such as anti-tumor, anti-inflammatory, analgesic, and the effects on cardiovascular system and nervous system, etc. However, its central nervous system toxicity severely limits its clinical application. Herein, the physicochemical properties, pharmacological activities, and toxicity of brucine were reviewed, and the novel strategies to address the toxicity issues were discussed, aiming to bring new insights into further research and application of this active component.

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Section: Toxicitymentioning

confidence: 99%

Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology

Huang

et al. 2020

Front. Pharmacol.

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“… 32 In addition, the therapeutic dose of strychnos alkaloids is close to the toxic dose. 33 For these reasons, it is urgent to alleviate the neurotoxicity caused by Semen Strychni and improve the application of Semen Strychni in clinic.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effect of total glycosides from paeonies against neurotoxicity induced by strychnos alkaloids related to recovering the levels of neurotransmitters and neuroendocrine hormones in rat serum and brain

et al. 2018

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“…Because it is strongly fat-soluble and easily distributed in the central nervous system (CNS) in the brain and other organs, it exerts severe CNS toxicity. 13,14 There is a narrow margin of safety between a therapeutic and a toxic dose. Thus, the key to reduce the toxicity and increase the effect of brucine is to increase the concentration of strychinin in its effect target and reduce its distribution in brain tissues to lower CNS toxicity.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

Li¹

2017

IJN

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In this study, a novel NGR (Asn-Gly-Arg) peptide-modified liposomal brucine was prepared by using spray-drying method. The surface morphology of the liposomes, encapsulation efficiency and particle size were investigated. The data showed that the addition of NGR did not produce any significant influence on brucine liposomes in terms of particle size or zeta potential. In addition, after 3 months of storage, no dramatic change such as visible aggregation, drug content changes or precipitation in the appearance of NGR-brucine liposomes occurred. The in vitro release results indicated that the release of brucine from NGR liposomes was similar to that of liposomes, demonstrating that the NGR modification did not affect brucine release. The in vitro drug-release kinetic model of NGR-brucine liposomes fitted well with the Weibull’s equation. In vivo, NGR-brucine liposomes could significantly extend the bioavailability of brucine; however, there was no significant difference observed in the pharmacokinetic parameters between liposomes and NGR liposomes after intravenous administration. Antitumor activity results showed that NGR-modified liposomes exhibited less toxicity and much higher efficacy in HepG2-bearing mice compared with non-modified liposomes. The enhanced antitumor activity might have occurred because brucine was specifically recognized by NGR receptor on the surface of tumor cells, which enhanced the intracellular uptake of drugs.

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Cytotoxicity and DNA interaction of brucine and strychnine—Two alkaloids of semen strychni

Cited by 33 publications

References 30 publications

Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology

Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology

Neuroprotective effect of total glycosides from paeonies against neurotoxicity induced by strychnos alkaloids related to recovering the levels of neurotransmitters and neuroendocrine hormones in rat serum and brain

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

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