Cytotoxicity and Proteasome Inhibition by Alkaloid Extract from<i>Murraya koenigii</i>Leaves in Breast Cancer Cells—Molecular Docking Studies

Ismail, Azman; Noolu, Bindu; Gogulothu, Ramesh; Shyam, Perugu; Ajumeera, Rajanna; Babu, Suresh K.

doi:10.1089/jmf.2016.3767

Cited by 18 publications

(7 citation statements)

References 24 publications

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“…A methanolic extract of M. koenigii was reported to have the ability to reduce proliferation in breast cancer cell lines [116]. The total alkaloid extracted from M. koenigii leaves has been shown to have promising cytotoxic activity in breast cancer cells, with an IC 50 of 14.4 µg/mL [117]. The anticancer activity of mahanine and isomahanine in human oral squamous cell carcinoma CLS-354 has also been reported [96].…”

Section: Anticancer Activity (In Vivo and In Vitro)mentioning

confidence: 97%

Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds

Balakrishnan

Vijayraja²,

et al. 2020

Antioxidants

118

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The discovery of several revitalizing molecules that can stop or reduce the pathology of a wide range of diseases will be considered a major breakthrough of the present time. Available synthetic compounds may provoke side effects and health issues, which heightens the need for molecules from plants and other natural resources under discovery as potential methods of replacing synthetic compounds. In traditional medicinal therapies, several plant extracts and phytochemicals have been reported to impart remedial effects as better alternatives. Murraya koenigii (M. koenigii) belongs to the Rutaceae family, which is commonly used as a medicinally important herb of Indian origin in the Ayurvedic system of medicine. Previous reports have demonstrated that the leaves, roots, and bark of this plant are rich sources of carbazole alkaloids, which produce potent biological activities and pharmacological effects. These include antioxidant, antidiabetic, anti-inflammatory, antitumor, and neuroprotective activities. The present review provides insight into the major components of M. koenigii and their pharmacological activities against different pathological conditions. The review also emphasizes the need for more research on the molecular basis of such activity in various cellular and animal models to validate the efficacy of M. koenigii and its derivatives as potent therapeutic agents.

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Section: Anticancer Activity (In Vivo and In Vitro)mentioning

confidence: 97%

Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds

Balakrishnan

Vijayraja²,

et al. 2020

Antioxidants

118

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“…Caspases-3 activity and TUNEL-positive cells enhanced after treatment with M. koenigii extract, indicating accelerated apoptosis (Noolu et al 2016). Total alkaloid extract from M. koenigii reduced breast cancer cell viability (IC50 = 14.4 g/mL), altered development dynamics, arrested cells in the "S" stage, and induced cell death (MDA-MB-231) (Ismail et al 2016). MTT assay showed the antitumor effectiveness of M. koenigii silver nanoparticles against breast cancer cell types (MDAMB-231).…”

Section: Murraya Koenigiimentioning

confidence: 99%

The use of medicinal plants for combating breast cancer: A comprehensive review

Alsubhi

2023

J Exp Bio & Ag Sci

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Breast carcinoma is a common illness among females. Various therapies, including hormone therapy, surgery, radiotherapy, chemotherapy, and targeted treatment, have been available to treat existing breast cancer. These therapies can potentially halt the development and spread of cancer, especially if the disease is at an early stage, but all these treatments have various adverse effects on human health. Cancer cells proliferate more rapidly than most normal cells, so chemotherapy is the most suitable treatment. Certain medications can cease dividing cells by destroying the cell's control center region. Other drugs can inhibit the chemical processes essential for cell division. On the contrary, because cancer is frequently identified at a late phase, treating the disease is extraordinarily challenging. Therefore, it is advisable to avoid this fatal condition from occurring. Multiple studies have revealed a continuous inverse connection between cancer and natural materials, such as plant extracts, their fractions, and active principles. These bioactive phytochemicals' have synergistic or cumulative effects in the treatment of cancer disease. This review article examined the effect of various extracts/fractions/active principles obtained from diverse plant origins against breast cancer disease. Information regarding the most commonly used plants, including Alpina galaga, Urtica dioica, Annona muricata, Rosmarinus officinalis, Ficus carica, Nigella sativa, Murraya koenigii, and Urtica dioica have been presented in this study. Owing to the information in this study, these plants exhibited anticancer activities in preclinical MCF-7 carcinoma models by decreasing cell proliferation, inducing programmed cell death, and triggering cell-cycle arrest. The information generated from this review will significantly contribute to developing knowledge of the scientific and medical communities in developing innovative breast cancer treatments.

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“…An experimental study reported the cytotoxic activities of alkaloid extract from M. koenigii in the breast cancer cell line MDA-MB-231 with an IC 50 of 14.4 μ g/mL [ 59 ]. Mahanine, a carbazole alkaloid isolated from M. koenigii and M. minutum, and its analogs have shown significant cytotoxic and anticancer activities in prostate cancer studies.…”

Section: Beneficial Pharmacological Activities Of M Koenigii M Minutum and C Indica mentioning

confidence: 99%

Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review

Abeysinghe

Alwis

Kumara

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Murraya koenigii (M. koenigii), Micromelum minutum (M. minutum), and Clausena indica (C. indica) are three varieties of curry leaves in the family Rutaceae. They have been widely used in Ayurvedic medicine worldwide in the treatment and prevention of various diseases. Earlier findings provide strong evidence to support the three curry leaf species’ potent pharmaceutical and biological effects, including antioxidant, antidiabetic, anti-inflammatory, and antitumor activities. Various parts of these plants, such as leaves, seeds, flowers, and fruit, contain constituents responsible for the modulation of numerous biological processes. Leading constituents of curry leaves play a crucial role in diabetic and anticancer management by regulating various molecular pathways, including Bcl-2, Bax, NF-κB, and TNFα, according to in vitro and in vivo models established. Therefore, this review summarizes the current knowledge on research achievements made in terms of phytoconstituents, their structures, biological activities, and pharmacological actions with clinical studies of curry leaves up to date. The review also emphasizes the necessity for comprehensive research studies on the pharmacological actions and the mechanisms of selected phytochemicals of M. koenigii, M. minutum, and C. indica to validate their efficacy as potent herbal remedies for many ailments.

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Cytotoxicity and Proteasome Inhibition by Alkaloid Extract fromMurraya koenigiiLeaves in Breast Cancer Cells—Molecular Docking Studies

Cited by 18 publications

References 24 publications

Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds

Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds

The use of medicinal plants for combating breast cancer: A comprehensive review

Nutritive Importance and Therapeutics Uses of Three Different Varieties (Murraya koenigii, Micromelum minutum, and Clausena indica) of Curry Leaves: An Updated Review

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