Cytotoxicity and Sensitization of Povidone-lodine and Other Frequently Used Anti-Infective Agents

Niedner, R.

doi:10.1159/000246038

Cited by 97 publications

(57 citation statements)

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“…This slow formation in the povidone-iodine control group was thought to be due to the toxicogenetic effects of povidone-iodine on fibroblasts which are cells that produce the collagen connective tissue. The disturbance of fibroblasts results in the expansion of collagen (Niedner 1997), as shown by the formation of thick scabs in the povidone-iodine control group. The largest expansion of collagen connective tissue was observed in both leaves extract dose groups.…”

Section: Discussionmentioning

confidence: 98%

The potential ethnomedicine plant of Impatiens balsamina leaves from Pontianak, West Kalimantan, Indonesia for wound healing

Fajriaty

Wijaya

et al. 2018

Nusantara Biosci

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Abstract. Hariyanto IH, Fajriaty I, Wijaya T, Hafizh M. 2018. The potential ethnomedicine plant of Impatiens balsamina leaves from Pontianak, West Kalimantan, Indonesia for wound healing. Nusantara Bioscience 10: 58-64. Pacar air or garden balsam (Impatiens balsamina L.) is a herb plant that grows wildly in high humidity areas. The leaves of I. balsamina are used by the people in Bengkulu, Indonesia, as herbal medicine to treat wounds. I. balsamina grows abundantly in West Borneo due to the proper conditions. This study aimed to determine the wound healing activity of I. balsamina as an ethnomedicine plant and standardize its extract. The leaves of I. balsamina was macerated with 96% ethanol. The extraction yield was 20.3%, the solubility of the extract in water and ethanol was 15.77% and 41.41%, respectively, the drying rate was 23.02%, and the extracted density was 0.8136 g/mL. The extract of I. balsamina contained polyphenols, flavonoids, saponins, tannins, quinones, steroids, and terpenoids based on the phytochemical screening. Anatomical and histological pathology tests showed that the leaves extract had the potential to heal the external wound.

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Section: Discussionmentioning

confidence: 98%

The potential ethnomedicine plant of Impatiens balsamina leaves from Pontianak, West Kalimantan, Indonesia for wound healing

Fajriaty

Wijaya

et al. 2018

Nusantara Biosci

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“…But it's more sensitizing and irritating than other surgical disinfection solution when applied to the skin and mucous membranes. 16 Though, the American congress of obstetrics and gynecology (ACOG) said that PI is not the perfect agent for preoperative vaginal disinfection. 7 Iodine can be absorbed through the vaginal mucosa as its nonkeratinized epithelium and can lead to serious risks in patients with significant iodine allergy as it can be absorbed after 2 minutes of contact between PI and the vaginal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Povidone-iodine versus normal saline solution in preoperative vaginal cleansing before office hysteroscopy: a randomized controlled trial

Abbas

Shaltout

Ali

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Hysteroscopy is well-thought-out the gold standard for assessing the uterine cavity, and now can be done as an office process due to enhanced endoscopic advances with no need to in-patient admission. Objective of the present study was to compare the difference in the rate of postoperative vaginal irritation symptoms and postoperative infections after using povidone iodine (PI) and normal saline (NS) solution in vaginal cleaning before outpatient office hysteroscopy (OH).Methods: Women attended to the hospital for diagnostic OH were included for present study. Eligible women were randomly allocated in a 1:1 ratio to two groups. Group I "PI group" women exposed to PI for vaginal cleansing before hysteroscopy, and group II "NS group” women exposed to the NS solution for vaginal cleansing. The primary outcome of the study was to compare the difference in the rate of postoperative vaginal irritation symptoms and postoperative infections in both groups.Results: The mean age of the study participants was 34.26±4.14 years for NS group compared to 35.22±4.01 years for PI group (p=0.652). The PI group reported higher rate of vaginal irritation than NS group with no statistically significant difference between the two groups (p=0.179). Both groups were similar in postoperative fever, urinary tract infection and vaginitis (p>0.05).Conclusions: This study concluded that preoperative vaginal disinfection at the time of OH with a NS solution is less frequently causing postoperative vaginal irritation symptoms. Additionally, it is as effective as the usual agent (PI) in preventing postoperative infections.

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“…In addition to causing pain, many disinfectants/ antimicrobials used to control microbial contamination/infection of the wound bed also have cytotoxic effects that prevent or delay healing (Niedner 1997, Hidalgo & Dominguez 2001, Drosou et al 2003, Wilson et al 2005, Banwell 2006). The present treatment protocol for wounds supported each phase of the healing process, avoiding the need to use cytotoxic disinfectants (Noble & Kent 1992, Lloyd et al 1999, Rantala et al 2004, Paterson et al 2005, Lee et al 2006.…”

Section: Discussionmentioning

confidence: 99%

Management of severe head injury with brain exposure in three loggerhead sea turtles Caretta caretta

Franchini¹,

Cavaliere²,

Valastro³

et al. 2016

Dis. Aquat. Org.

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The loggerhead Caretta caretta is the most common sea turtle in the Mediterranean. Currently, sea turtles are considered endangered, mainly due to the impact of human activities. Among traumatic lesions, those involving the skull, if complicated by brain exposure, are often life-threatening. In these cases, death could be the outcome of direct trauma of the cerebral tissue or of secondary meningoencephalitis. This uncontrolled study aims to evaluate the use of a plantderived dressing (1 Primary Wound Dressing ® ) in 3 sea turtles with severe lesions of the skull exposing the brain. Following surgical curettage, the treatment protocol involved exclusive use of the plant-derived dressing applied on the wound surface as the primary dressing, daily for the first month and then every other day until the end of treatment. The wound and peri-wound skin were covered with a simple secondary dressing without any active compound (non-woven gauze with petroleum jelly). Data presented herein show an excellent healing process in all 3 cases and no side effects due to contact of the medication with the cerebral tissue.

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Cytotoxicity and Sensitization of Povidone-lodine and Other Frequently Used Anti-Infective Agents

Cited by 97 publications

References 0 publications

The potential ethnomedicine plant of Impatiens balsamina leaves from Pontianak, West Kalimantan, Indonesia for wound healing

The potential ethnomedicine plant of Impatiens balsamina leaves from Pontianak, West Kalimantan, Indonesia for wound healing

Povidone-iodine versus normal saline solution in preoperative vaginal cleansing before office hysteroscopy: a randomized controlled trial

Management of severe head injury with brain exposure in three loggerhead sea turtles Caretta caretta

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