Cytotoxicity, antimicrobial and antidiarrhoeal activities of standardised aqueous root extract of<i>Elephantorrhiza elephantina</i>(Burch.)

Sabiu, Saheed; Tom, Ashafa Anofi Omotayo

doi:10.1080/0035919x.2016.1259687

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…However, the possibility that synergistic interactions among different compounds in the polar extracts are possible contributors to the higher toxicity of the polar as compared to non-polar extracts cannot be neglected. Based on the brine shrimp lethality assay, the water extract of Elephantorrhiza elephantina rhizome was considered credible with much potential as chemotherapeutic agent with an LC 50 value of 42.2 µg/mL, implying its safety for consumption [50]. Similarly, Maphosa, et al [51] indicated the lack of toxicity of the water extracts of Elephantorrhiza elephantina based on an acute toxicity test.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity, Antioxidant Potential, Cytotoxicity and Phytochemical Profiling of Four Plants Locally Used against Skin Diseases

Asong

Amoo

McGaw

et al. 2019

Plants

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Although orthodox medications are available for skin diseases, expensive dermatological services have necessitated the use of medicinal plants as a cheaper alternative. This study evaluated the pharmacological and phytochemical profiles of four medicinal plants (Drimia sanguinea, Elephantorrhiza elephantina, Helichrysum paronychioides, and Senecio longiflorus) used for treating skin diseases. Petroleum ether and 50% methanol extracts of the plants were screened for antimicrobial activity against six microbes: Bacillus cereus, Shigella flexneri, Candida glabrata, Candida krusei, Trichophyton rubrum and Trichophyton tonsurans using the micro-dilution technique. Antioxidant activity was conducted using 2,2-diphenyl-1-picryhydrazyl (DPPH) free radical scavenging and β-carotene linoleic acid models. Cytotoxicity was determined against African green monkey Vero kidney cells based on the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. Spectrophotometric and Gas Chromatography-Mass Spectrometry (GC-MS) methods were used to evaluate the phytochemical constituents. All the extracts demonstrated varying degrees of antimicrobial potencies. Shigella flexneri, Candida glabrata, Trichophyton rubrum and Trichophyton tonsurans were most susceptible at 0.10 mg/mL. In the DPPH test, EC50 values ranged from approximately 6–93 µg/mL and 65%–85% antioxidant activity in the β-carotene linoleic acid antioxidant activity model. The phenolic and flavonoid contents ranged from 3.5–64 mg GAE/g and 1.25–28 mg CE/g DW, respectively. The LC50 values of the cytotoxicity assay ranged from 0.015–5622 µg/mL. GC-MS analysis revealed a rich pool (94–198) of bioactive compounds including dotriacontane, benzothiazole, heptacosane, bumetrizole, phthalic acid, stigmasterol, hexanoic acid and eicosanoic acid, which were common to the four plants. The current findings provide some degree of scientific evidence supporting the use of these four plants in folk medicine. However, the plants with high cytotoxicity need to be used with caution.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity, Antioxidant Potential, Cytotoxicity and Phytochemical Profiling of Four Plants Locally Used against Skin Diseases

Asong

Amoo

McGaw

et al. 2019

Plants

View full text Add to dashboard Cite

show abstract

“…A detailed information on region based ethnopharmacological uses of Elephantorrhiza elephantina has been given in a review by Maroyi Alfred. 61 The major disorders treated with this shrub are gastrointestinal problems where it has been found very effective in the treatment of bloody diarrhoea and dysentery, 62 it is also used to treat skin diseases like acne, 63 sexual disorders like erectile dysfunction, syphilis, herpes, HIV/AIDS. [64][65][66] It is also sold as herbal medicines in the local markets under different vernacular names and is consumed in the form of root decoction.…”

Section: Elephantorrhiza Elephantinamentioning

confidence: 99%

Characterization of Microwave-Assisted Extracts of Citrus sinensis Exocarp and Mesocarp Peels for their Pharmaceutical Excipient Potentia

Farooqi¹,

Siraj²,

Adhami³

2023

TJPPS

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Evidence based traditional anti-diarrheal medicinal plants and their phytocompounds

Rawat

Singh

Kumar

2017

Biomedicine & Pharmacotherapy

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Cytotoxicity, antimicrobial and antidiarrhoeal activities of standardised aqueous root extract ofElephantorrhiza elephantina(Burch.)

Cited by 4 publications

References 42 publications

Antimicrobial Activity, Antioxidant Potential, Cytotoxicity and Phytochemical Profiling of Four Plants Locally Used against Skin Diseases

Antimicrobial Activity, Antioxidant Potential, Cytotoxicity and Phytochemical Profiling of Four Plants Locally Used against Skin Diseases

Characterization of Microwave-Assisted Extracts of Citrus sinensis Exocarp and Mesocarp Peels for their Pharmaceutical Excipient Potentia

Evidence based traditional anti-diarrheal medicinal plants and their phytocompounds

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