Cytotoxicity, Antioxidant and Antiviral Potential of Aqueous Extract from Nostoc muscorum Cultivated in Various Inexpensive Media

Shalaby, Emad A.; Atta, Mohamed; Sleem, Ibtesam A.; Mohamed, Mousa A.; Lightfoot, David A.; El‐Shemy, Hany A.

doi:10.1007/s12649-017-0188-3

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…The effect of the crude extract is concentration-dependent (31.25-500 g/mL), according to these findings. For these cells, the effect can be described as receptor-independent, as reported [99]. Furthermore, as previously noted in Table 10, the anticancer character of the crude extract may be related to its abundance of bioactive compounds.…”

Section: Discussionmentioning

confidence: 65%

Potential Antioxidant and Anticancer Activities of Secondary Metabolites of Nostoc linckia Cultivated under Zn and Cu Stress Conditions

et al. 2021

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The objective of the present study is to determine the antioxidant and anticancer activities of Nostoc linckia extracts cultivated under heavy metal stress conditions (0.44, 0.88, and 1.76 mg/L for zinc and 0.158, 0.316, 0.632 mg/L for copper). Phycobiliprotein, phenolic compounds, flavonoids, and tannins were measured. Active ingredients of extracts were evaluated by GC-mass spectroscopy. The obtained results revealed that higher zinc and copper concentrations showed growth inhibition while 0.22 mg/L (Zn) and 0.079 mg/L (Cu) enhanced growth, reaching its maximum on the 25th day. Increases in catalase, lipids peroxidation, and antioxidants, as well as tannins and flavonoids, have been induced by integration of 0.88 mg/L (Zn) and 0.316 mg/L (Cu). Elevation of Zn concentration induced augmentation of antioxidant activity of crude extract (DPPH or ABTS), with superior activity at 0.44 mg/L zinc concentration (81.22%). The anticancer activity of Nostoc linckia extract (0.44 mg/L Zn) tested against four cancer cell lines: A549, Hela, HCT 116, and MCF-7. The extract at 500 µg/mL appeared the lowest cell viability of tested cell lines. The promising extract (0.44 mg/L Zn) recorded the lowest cell viability of 25.57% in cervical cell line, 29.74% in breast cell line, 33.10% in lung cell line and 34.53% in the colon cell line. The antioxidant active extract showed significant stability against pH with attributed increase in antioxidant activity in the range between 8–12. The extract can be used effectively as a natural antioxidant and anticancer after progressive testing.

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Section: Discussionmentioning

confidence: 65%

Potential Antioxidant and Anticancer Activities of Secondary Metabolites of Nostoc linckia Cultivated under Zn and Cu Stress Conditions

et al. 2021

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“…Cyanobacteria are known for Among the cyanobacteria, the species from the genus Nostoc stand out as ideal candidates for biopharmaceutical applications (Cibichakravarthy et al, 2019). There are over 40 different Nostoc species that produce more than 120 bioproducts with antiviral, antioxidant, anticancer, antifungal and antimicrobial activities (Shalaby et al, 2019). These species are found in gelatinous colonies, composed of filaments called "trichomes"surrounded by a thin mucilaginous sheath that excrete EPS, which released is mainly concerned with protecting cells from physical or chemical stress and for anchorage purposes (Garlapati et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Modeling the effects of light wavelength on the growth of Nostoc ellipsosporum

Ortiz-Moreno¹,

Cárdenas-Poblador²,

Agredo³

et al. 2020

Univ. Sci.

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Mathematical models provide information about population dynamics under different conditions. In the study, four models were evaluated and employed to describe the growth kinetics of Nostoc ellipsosporum with different light wavelengths: Baranyi-Roberts, Modiﬁed Gompertz, Modiﬁed Logistic, and Richards. N. ellipsosporum was grown in BG-11 liquid medium for 9 days, using 12 hours of photoperiod and the following treatments: white light (400-800 nm), red light (650-800 nm), yellow light (550-580 nm) and blue light (460-480 nm). Each experiment was performed in triplicate. The optical density (OD) was measured on days 1, 3, 5, 7 and 9, using a spectrophotometer at 650 nm. The maximum cell growth was obtained under white light (OD650 : 0.090 ± 0.008), followed by the yellow light (OD650 :0.057 ± 0.004). Conversely, blue light showed a marked inhibitory effect on the growth of N. ellipsosporum (OD650 : 0.009 ± 0.001). The results revealed that the Baranyi-Roberts model had a better ﬁt with the experimental data from N. ellipsosporum growth in all four treatments. The ﬁndings from this modeling study could be used in several biotechnological applications that require the productionof N. ellipsosporum and its bioproducts.

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“…The results were in context with those reported by Wang et al, [18] who mentioned that, some microalgae (as C. vulgaris) could effectively acclimatize on various wastewaters (municipal wastewater treatment plant, MWTP) without lag phase. Similarly, Shalaby et al, [26] described that N. muscorum was adapted well when cultivated on several types of wastewaters (Sewage, Industrial and Agriculture).…”

Section: Growth Rate With Different Treatmentsmentioning

confidence: 88%

Enhancement of plant growth regulators production from microalgae cultivated in treated sewage wastewater (TSW)

2022

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The aim of this work is to develop an efficient method for detection and evaluation of the plant growth regulators produced from cyanobacteria species (Anabaena oryzae and Nostoc muscorum) cultivated on BG110, and Chlorophyta alga (Chlorella vulgaris) cultivated on BG11 in addition to the cultivation of these strains on treated sewage wastewater (TSW) combined with control media (BG11 and BG110) at different concentrations (100, 75 and 50%). Bioassays were performed on Wheat coleoptile length and Cucumber cotyledons fresh weight for indole acetic acid (IAA) and Benzyl adenine (BA) detection. In addition, application experiments of IAA and BA presence in algal extract were applied on tomato plantlets and soybean callus. The obtained results of A. oryzae and N. muscorum extracts (grown on BG110 and 100% sewage media) with optimum conc. of IAA and BA showed moderate shoot length and leaves number as well as high root initiation of tomato explant compared to control. While dimethyl sulfoxide (DMSO), IAA conc. as well as IAA + BA conc. showed no effect on branching and leaf expansion. The results of C. vulgaris (grown on BG11) also revealed that the shoot had high leaves number and greatest root initiation, without branching and leaf expansion. On the other hand, 100% TSW had a moderate shoot, leaves number and high root initiation. Extracts of A. oryzae and N. muscorum (grown on BG110) induced 1.5-fold increase in soybean callus fresh weight, while the growth on 100% TSW was shown to be less effective. Moreover, extract of C. vulgaris (grown on BG11) induced a moderate effect, while its growth on 100% TSW was shown to be less effective in soybean callus fresh weight increment.

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Cytotoxicity, Antioxidant and Antiviral Potential of Aqueous Extract from Nostoc muscorum Cultivated in Various Inexpensive Media

Cited by 6 publications

References 30 publications

Potential Antioxidant and Anticancer Activities of Secondary Metabolites of Nostoc linckia Cultivated under Zn and Cu Stress Conditions

Potential Antioxidant and Anticancer Activities of Secondary Metabolites of Nostoc linckia Cultivated under Zn and Cu Stress Conditions

Modeling the effects of light wavelength on the growth of Nostoc ellipsosporum

Enhancement of plant growth regulators production from microalgae cultivated in treated sewage wastewater (TSW)

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