Cytotoxicity Assay of Ethyl Acetate Extract Shimeji (<i>Lyophyllum shimeji</i> (Kawam.) Hongo) and White Oyster Mushroom (<i>Pleurotus ostreatus</i> Jacq.) Against HCT-116 Cell Line

Rossiana, Nia; Madihah,; Nur, Andi Agus; Mayawatie, Betty; Andayaningsih, Poniah

doi:10.1088/1755-1315/197/1/012007

Cited by 3 publications

(2 citation statements)

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“…The antibacterial activities of thirty mushroom species belonging to Basidiomycetes and Ascomycetes, cultivated on two liquid media, were evaluated against grampositive (Bacillus subtilis and Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria by the disk diff usion method. Lyophyllum shimeji, showed antibacterial activity levels-from 9.5 mm in diameter of the inhibition zone to full inhibition of growth of the test bacteria [61].…”

Section: Lyophyllum Shimeji Biological Activitiesmentioning

confidence: 97%

Nameko Mushroom (Pholiota microspore), Hiratake Mushroom (Pleurotus ostreatus) and Shimeji Mushrooms (Lyophyllum shimeji): Bioactive Compounds as a Source of Various Biological Activities: A Review

A Elkhateeb,

Daba

2024

J Biomed Res Environ Sci

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Mushrooms are substantial source of nutritional, medicinal compounds, and other benefits compounds still need to be worked out for their important applications. Mushrooms as higher Basidiomycetes and Ascomycetes contain secondary metabolites in their fruit bodies, cultured mycelium, and cultured broth. These secondary metabolites have been used in many sides of human activity for many years for maintaining long and healthy life. The genera Pholiota, Pleurotus and Lyophyllum are a group of edible mushrooms that are distributed all over the world. The studies on different species of these edible mushrooms have revealed their nutritional medicinal potentials. This review aims to present the importance of Pholiota microspore, Pleurotus ostreatus and Lyophyllum shimeji, as both food and medicine, and they offer new visions to researchers to develop new drugs and nutraceuticals.

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Section: Lyophyllum Shimeji Biological Activitiesmentioning

confidence: 97%

Nameko Mushroom (Pholiota microspore), Hiratake Mushroom (Pleurotus ostreatus) and Shimeji Mushrooms (Lyophyllum shimeji): Bioactive Compounds as a Source of Various Biological Activities: A Review

A Elkhateeb,

Daba

2024

J Biomed Res Environ Sci

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“…The 14.5-kDa Lyophyllum shimeji ribonuclease suppressed proliferation of MCF7 cells with an IC50 of 6.2 μM (Zhang et al 2010a). An inhibitory action of the protein extract from Lyophyllum shimeji toward human oral squamous cell carcinoma (Jung et al 2014) and ethyl acetate extract toward colorectal HCT-116 cells (Rossiana et al 2018) has been reported.…”

Section: Lyophyllum Shimejimentioning

confidence: 99%

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Wong

Chan

et al. 2020

Appl Microbiol Biotechnol

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This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus bisporus, Brazilian mushroom Agaricus blazei, Amauroderma rugosum, stout camphor fungus Antrodia camphorata, Jew's ear (black) fungus or black wood ear fungus Auricularia auricula-judae, reishi mushroom or Lingzhi Ganoderma lucidum, Ganoderma sinense, maitake mushroom or sheep's head mushroom Grifola frondosa, lion's mane mushroom or monkey head mushroom Hericium erinaceum, brown beech mushroom Hypsizigus marmoreus, sulfur polypore mushroom Laetiporus sulphureus, Lentinula edodes (shiitake mushroom), Phellinus linteus (Japanese "meshimakobu," Chinese "song gen," Korean "sanghwang," American "black hoof mushroom"), abalone mushroom Pleurotus abalonus, king oyster mushroom Pleurotus eryngii, oyster mushroom Pleurotus ostreatus, tuckahoe or Fu Ling Poria cocos, and split gill mushroom Schizophyllum commune. Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes. Agaricus placomycesThe 68-kDa laccase from Agaricus placomyces belongs to a family of copper-containing oxidases involved in lignin degradation and possessing anticancer activity (Mizerska-Dudka et al. 2015). It potently expressed antiproliferative activity toward MCF-7 human breast cancer cells with an IC50 of 1.8 μM (Sun et al. 2012). Agaricus sylvaticusIn a randomized, double-blind, and placebo-controlled clinical trial, 46 patients with stage II and III breast cancer who received chemotherapy demonstrated an improved appetite and fewer gastrointestinal complaints, nausea, and vomiting following dietary supplementation with A. sylvaticus (2.1 g/day) (Valadares et al. 2013). Amauroderma rude Amauroderma rude had higher tumoricidal activity than Ganoderma lucidum. A. rude lowered cell survival and triggered apoptosis in MDA-MB-231 breast cancer cells. Tumor growth in athymic nude mice bearing MDA-MB-231-xenografts was retarded and tumor cell death was promoted by treatment with A. rude. Expression of the c-Myc oncogene was downregulated . A. rude exhibited a higher content of ergosterol (ergosta-5,7,22-trien-3β-ol) in comparison with 12 other mushrooms examined. Under the influence of ergosterol, the viability of MDA-MB-231 breast cancer cells was reduced, whereas expression of the tumor suppressor Foxo3 and downstream signaling molecules including BimL, BimS, Fas, and FasL was enhanced resulting in apoptosis of the breast cancer cells (Li et al. 2015).Amauroderma rugosum (also known as black Lingzhi, a member of five-color Lingzhi) Organic molecules from A. rugosum inhibited oxidant activity, tumor necrosis factor-α and nitric oxide formation, and MCF7 cell proliferation (Zhang et al. 2017a). A single treatment with pulverized A. rugosum (2000 mg/kg) by mouth did not impair growth, blood parameters, histological structures of t...

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Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions

Panda

Paul

Singdevsachan

et al. 2021

CPB

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Background: Nowadays medicines derived from natural sources have drawn much attention as potential therapeutic agents in the suppression and treatment of cancer because of their low toxicity and fewer side effects. Objective: The present review aims to assess the currently available knowledge on the ethnomedicinal uses and pharmacological activities of bioactive compounds obtained from medicinal mushrooms towards cancer treatment. Methods: Literature search has been conducted for the collection of research papers from universally accepted scientific databases. These research papers and published book chapters were scrutinized to retrieve information on ethnomedicinal uses of mushrooms, different factors involved in cancer cell proliferation, clinical and in silico pharmaceutical studies made for possible treatments of cancer using mushroom derived compounds. Overall 241 articles were retrieved and reviewed from the year of 1970 to 2020, out of which 98 relevant articles were finally considered for preparation of this review. Results: This review presents an update on the natural bioactive substances derived from medicinal mushrooms and their role in inhibiting the factors responsible for cancer cell proliferation. Along with it, the present review also provides information on the ethnomedicinal uses, solvents used for extraction of anticancer metabolites, clinical trials, and in silico studies that were undertaken towards anticancer drug development from medicinal mushrooms. Conclusion: The present review provides an extensive knowledge on various anticancer substances obtained from medicinal mushrooms, their biological actions and in silico drug designing approaches which could form a basis for the development of natural anticancer therapeutics.

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Cytotoxicity Assay of Ethyl Acetate Extract Shimeji (Lyophyllum shimeji (Kawam.) Hongo) and White Oyster Mushroom (Pleurotus ostreatus Jacq.) Against HCT-116 Cell Line

Cited by 3 publications

References 4 publications

Nameko Mushroom (Pholiota microspore), Hiratake Mushroom (Pleurotus ostreatus) and Shimeji Mushrooms (Lyophyllum shimeji): Bioactive Compounds as a Source of Various Biological Activities: A Review

Nameko Mushroom (Pholiota microspore), Hiratake Mushroom (Pleurotus ostreatus) and Shimeji Mushrooms (Lyophyllum shimeji): Bioactive Compounds as a Source of Various Biological Activities: A Review

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials

Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions

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