Cytotoxicity effects and biochemical investigation of novel tetrakis-phthalocyanines bearing 2-thiocytosine moieties with molecular docking studies

A review on α-glucosidase inhibitory activity of first row transition metal complexes: a futuristic strategy for treatment of type 2 diabetes

“…3) with various substituted phthalocyanines ( L60 , L62–L67 , L72 , Table 7, entries 1, 3–8, 13) has been recently reported. 105–114 Among them, complex 143 containing sodium 2-mercaptoethanesulfonate moiety ( L66 , Table 7, entry 7) with IC 50 value of 1.93 μM showed the best inhibitory effect comparing with acarbose as the reference drug (IC 50 = 22.80 μM). 110 It should be noted that complex 142 (IC 50 = 111.63 μM, acarbose = 189.20 μM) which had sodium 3-mercaptoethanesulfonate moiety ( L65 ), 110 depicted 198-fold lower activity than 143 , indicating the effect of the position of substituents.…”

“…3) of phthalocyanine derivatives ( L60 , L61 , L64 , L68 , L69 , and L72 , Table 7, entries 1, 2, 5, 9, 10, and 13) have been evaluated for their α-glucosidase inhibitory activity and compared with acarbose as the reference drug. 105,106,108–110,112 In this respect, the best activity was related to the complex 148 (IC 50 = 0.81 μM, acarbose = 22.80 μM) containing 3,4-dimethoxyphenethoxy moiety ( L72 , Table 7, entry 13) 110 and the complex 146 (IC 50 = 911.20 μM, acarbose = 0.38 μM) possessing oxy methyl furan group ( L60 , Table 7, entry 1) was the weakest inhibitor. 106 Moreover, α-glucosidase inhibitory effect of the copper( ii ) phthalocyanine 147 containing 1,2,3-triazole moiety ( L64 , Table 7, entry 5) was found to be relatively more active (IC 50 = 42.14 μM) than acarbose (IC 50 = 51.45 μM).…”

Biological activity and molecular docking studies of some N‐phenylsulfonamides against cholinesterases and carbonic anhydrase isoenzymes

“…In addition, their inhibition abilities were compared with standard compounds. On the other hand, as it is known, there are many computational studies on related target enzymes in the literature 52‐56 . Therefore, a molecular docking study for some strong candidates ( 9 , 10 , 11 , and 12 ) for the above‐mentioned targets is also performed in this research.…”

“…On the other hand, as it is known, there are many computational studies on related target enzymes in the literature. [52][53][54][55][56] Therefore, a molecular docking study for some strong candidates (9, 10, 11, and 12) for the above-mentioned targets is also performed in this research. As a result, the inhibition studies of the previously synthesized compounds against these enzymes and docking studies of some of them were carried out for the first time in this study.…”

Quinoline‐fused both non‐peripheral and peripheral ZnIIand MgIIphthalocyanines: Anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, and in silico studies

“…[26][27][28] There are many studies in the literature on acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and glucosidase enzymes of cobalt and copper phthalocyanines. [29][30][31][32][33][34][35][36] Besides, there are very few studies on these properties of phthalocyanine compounds containing quinoline groups. In this study, we wanted to examine these properties of quinoline substituted zinc and magnesium phthalocyanines, unlike the literature.…”