Cytotoxicity evaluation of green synthesized ZnO and Ag-doped ZnO nanoparticles on brain glioblastoma cells

Hamidian, Khadijeh; Sarani, Mina; Sheikhi, Emad; Khatami, Mehrdad

doi:10.1016/j.molstruc.2021.131962

Cited by 44 publications

(34 citation statements)

References 44 publications

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“…Nanoparticle-mediated therapy is the best and alternative therapeutic strategy in cancer therapy. NPs have been employed as medication delivery system because of their potential to target specific sick cells or tumour tissues by encapsulating the therapeutic drug in the nanoparticles [153][154][155]. Even though several nanoparticle-mediated techniques have been developed, physicians and nanotechnologists are facing a massive challenge in developing specialised compositions to specifically target individual cancer, due to the variation of the tumour and its surroundings.…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications

Rahuman

Dhandapani

Narayanan

et al. 2022

IET Nanobiotechnology

187

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The alarming effect of antibiotic resistance prompted the search for alternative medicine to resolve the microbial resistance conflict. Over the last two decades, scientists have become increasingly interested in metallic nanoparticles to discover their new dimensions. Green nano synthesis is a rapidly expanding field of interest in nanotechnology due to its feasibility, low toxicity, eco-friendly nature, and long-term viability. Some plants have long been used in medicine because they contain a variety of bioactive compounds. Silver has long been known for its antibacterial properties. Silver nanoparticles have taken a special place among other metal nanoparticles. Silver nanotechnology has a big impact on medical applications like bio-coating, novel antimicrobial agents, and drug delivery systems. This review aims to provide a comprehensive understanding of the pharmaceutical qualities of medicinal plants, as well as a convenient guideline for plant-based silver nanoparticles and their antimicrobial activity. K E Y W O R D Santimicrobial, eco-friendly, green synthesis, silver nanoparticles | INTRODUCTIONNanotechnology is a growing industry that can be used to create nanoscale structures. Nanoproducts are concerned with the approach and synthesis of particles with a diameter ranging from 1 to 100 nm. In living beings, nanotechnology is a combination of wet, dry, and computerised nanotechnology. Wet nanotechnology encompasses biological agents such as membranes, organs, and enzymes. Dry nanotechnology deals with surface science, physical, chemical properties, and the production of inorganic materials such as silicon and carbon. Modelling and simulation of complex nanometre-scale structures are part of computational nanotechnology [1]. Figure 1 depicts how these three disciplines were intertwined for optimal functionality. Nanoscale compounds can be distinguished by specific properties, opening up a wide range of applications, as well as the extension of science nanoscale discipline and research opportunities. It is used in a variety of Haajira Beevi Habeeb Rahuman and Ranjithkumar Dhandapani have contributed equally and share first authorship.

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Section: Anti-cancer Activitymentioning

confidence: 99%

Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications

Rahuman

Dhandapani

Narayanan

et al. 2022

IET Nanobiotechnology

187

View full text Add to dashboard Cite

show abstract

“…The Raman spectrum of the pure ZnO sample ( Figure 3 a) consisted of four predominant bands located at about 99, 380, 437, and 573 cm −1 , which correspond to the fundamental phonon modes of ZnO wurtzite structure [ 18 ], in accordance with the XRD results. The Ag/ZnO spectra ( Figure 3 b,c) show characteristic peaks centered at 99 and 435 cm −1 , which can be assigned the fundamental phonon modes E 2 low and E 2 high of hexagonal wurtzite ZnO, respectively [ 30 , 31 ]. The A 1 (LO) polar branches appeared at about 555 cm −1 for the samples decorated with Ag.…”

Section: Resultsmentioning

confidence: 99%

“…Such a shift and broadening of A 1 (LO) phonon mode can be attributed to the scattering contributions with the phonons away from the center of Brillouin zone [ 32 ]. The A 1 (LO) phonon mode is commonly assigned to the oxygen vacancies (V o ) [ 32 , 33 , 34 ], zinc interstitial (Zn i ) defects in ZnO [ 31 , 34 ], or defect complexes of combined V o and Zn i in the host lattice [ 34 ]. Additionally, a broad Raman peak positioned at about 483 cm −1 only appeared in the spectra of the samples containing Ag, which was assigned as the interfacial surface phonon mode in the literature [ 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Ag/ZnO Nanoparticles for Bacteria Disinfection in Water

et al. 2022

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In this study, two green synthesis routes were used for the synthesis of Ag/ZnO nanoparticles, using cassava starch as a simple and low-cost effective fuel and Aloe vera as a reducing and stabilizing agent. The Ag/ZnO nanoparticles were characterized and used for bacterial disinfection of lake water contaminated with Escherichia coli (E. coli). Characterization indicated the formation of a face-centered cubic structure of metallic silver nanoparticles with no insertion of Ag into the ZnO hexagonal wurtzite structure. Physicochemical and bacteriological analyses described in “Standard Methods for the Examination of Water and Wastewater” were used to evaluate the efficiency of the treatment. In comparison to pure ZnO, the synthesized Ag/ZnO nanoparticles showed high efficiencies against Escherichia coli (E. coli) and general coliforms present in the lake water. These pathogens were absent after treatment using Ag/ZnO nanoparticles. The results indicate that Ag/ZnO nanoparticles synthesized via green chemistry are a promising candidate for the treatment of wastewaters contaminated by bacteria, due to their facile preparation, low-cost synthesis, and disinfection efficiency.

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“…New developments in science, bioinformatics and nanotechnology have significant impact on human health and life [ 203 , 204 , 205 , 206 , 207 ]. Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body [ 208 , 209 , 210 , 211 , 212 , 213 ]. In this light, a hybrid material based on PAA and mesoporous silica nanoparticles was used for drug delivery systems in various ways, including surface modification, doxorubicin hydrochloride loading, and PAA coating.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

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Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

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Cytotoxicity evaluation of green synthesized ZnO and Ag-doped ZnO nanoparticles on brain glioblastoma cells

Cited by 44 publications

References 44 publications

Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications

Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications

Synthesis and Characterization of Ag/ZnO Nanoparticles for Bacteria Disinfection in Water

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

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