Cytotoxicity of anodized titanium and polycrystalline zirconia in cultured mammalian cells.

Kanematsu, Nobutake; Shibata, Kan-ichi; Yamagami, Akiyoshi; Kotera, Shuhei; Yoshihara, Yoichiro

doi:10.2330/joralbiosci1965.27.382

Cited by 6 publications

(5 citation statements)

References 1 publication

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“…The diameter of the implants was 3.2 mm and the length of the endosseous portion was 10 mm. An oxidized layer of 1350 to 1400 Å thickness was deposited on the implant surface by anodic oxidization (Kanematsu et al 1985), thereby increasing its affinity for the tissue. The portion of the implant surface that is normally in contact with the human gingiva was polished until it shone like a mirror.…”

Section: Methodsmentioning

confidence: 99%

Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits

Matsumoto

Ochi

Abiko

et al. 2000

Clinical Oral Implants Res

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The present study examined the effect of applying a pulsed electromagnetic field (PEMF) on bone formation around a rough-surfaced dental implant. A dental implant was inserted into the femur of Japanese white rabbits bilaterally. A PEMF with a pulse width of 25 microseconds and a pulse frequency of 100 Hz was applied. PEMF stimulation was applied for 4 h or 8 h per day, at a magnetic intensity of 0.2 mT, 0.3 mT or 0.8 mT. The animals were sacrificed 1, 2 or 4 weeks after implantation. After staining the resin sections with 2% basic fuchsin and 0.1% methylene blue, newly formed bone around the implant on tissue sections was evaluated by computer image analysis. The bone contact ratios of the PEMF-treated femurs were significantly larger than those of the control groups. Both the bone contact ratio and bone area ratio of the 0.2 mT- and 0.3 mT-treated femurs were significantly larger than the respective value of the 0.8 mT-treated femurs (P < 0.001). No significant difference in bone contact ratio or bone area ratio was observed whether PEMF was applied for 4 h/day or 8 h/day. Although a significantly greater amount of bone had formed around the implant of the 2-week treated femurs than the 1-week treated femurs, no significant difference was observed between the 2-week and 4-week treated femurs. These results suggest that PEMF stimulation may be useful for promoting bone formation around rough-surfaced dental implants. It is important to select the proper magnetic intensity, duration per day, and length of treatment.

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Section: Methodsmentioning

confidence: 99%

Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits

Matsumoto

Ochi

Abiko

et al. 2000

Clinical Oral Implants Res

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“…These effects of radioelements and its cytotoxicity were investigated using gamma rays on zirconium head and no cytotoxicity was reported. 164,165 45S5 Bioglass-titanium bulk and scaffold composites For biomedical applications, 45S5 bioglass is the most widely used glass for over 40 years. The reactions on the glass surface induce release as well as exchange of critical concentrations of silicon, calcium, sodium, and phosphorus ions.…”

Section: Metallic Glassesmentioning

confidence: 99%

“…Sometimes zirconium contains traces of radioelements. These effects of radioelements and its cytotoxicity were investigated using gamma rays on zirconium head and no cytotoxicity was reported …”

Section: Types Of Bioglassesmentioning

confidence: 99%

A review of bioactive glasses: Their structure, properties, fabrication and apatite formation

Kaur

Pandey

Singh

et al. 2013

J. Biomed. Mater. Res.

512

273

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Bioactive glass and glass-ceramics are used in bone repair applications and are being developed for tissue engineering applications. Bioactive glasses/Bioglass are very attractive materials for producing scaffolds devoted to bone regeneration due to their versatile properties, which can be properly designed depending on their composition. An important feature of bioactive glasses, which enables them to work for applications in bone tissue engineering, is their ability to enhance revascularization, osteoblast adhesion, enzyme activity and differentiation of mesenchymal stem cells as well as osteoprogenitor cells. An extensive amount of research work has been carried out to develop silicate, borate/borosilicate bioactive glasses and phosphate glasses. Along with this, some metallic glasses have also been investigated for biomedical and technological applications in tissue engineering. Many trace elements have also been incorporated in the glass network to obtain the desired properties, which have beneficial effects on bone remodeling and/or associated angiogenesis. The motivation of this review is to provide an overview of the general requirements, composition, structure-property relationship with hydroxyapatite formation and future perspectives of bioglasses.Attention has also been given to developments of metallic glasses and doped bioglasses along with the techniques used for their fabrication.

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“…The results showed no signs of implant rejection or prolapse of the implanted piece. Kanematsu [28] tested alumina composites in L cell line cultures and displayed same colony formation. The release of cisplatin from nickel supported Al2O3 formulations has been studied as a function of time.…”

Section: Discussionmentioning

confidence: 81%

Cisplatin delivery from nickel supported Al2O3 powders: characterization with swelling and mutagenity tests

Yalçın¹,

Şengül²,

Ozdemir³

et al. 2012

Turk J Bioch

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Objective: In this study cisplatin release profile of Al 2 O 3 powders with nickel phase supportion was investigated. Swelling property, mutagenity test and FTIR analysis were achieved for characterization of powders. Methods: Different formulations of nickel supported Al 2 O 3 powders were synthesized for cisplatin release studies. Swelling ratio, Fourier transform infrared spectroscopy spectrum and Ames test were investigated for the characterization of Al 2 O 3 and nickel supported Al 2 O 3 powders. In vitro cisplatin release were studied in physiological saline solution and the amount of released cisplatin was determined with spectrophotometric analysis. Results: The powders showed a swelling degree between 46-86% and swelling ratio increased with increasing Ni phase. This behaviour has been explained on the basis of the softer character of nickel phase. And the results of Ames test indicate that all powder formulations are non-mutagenic. The release of cisplatin was studied as a function of time and all formulations showed non-Fickian diffusion with n value ranged between 0.55 and 0.69. Conclusion:The nickel supported Al 2 O 3 formulations designed in this study, shows great promise as a cisplatin release material due to the favorable characteristics identified in these studies. Keywords

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Cytotoxicity of anodized titanium and polycrystalline zirconia in cultured mammalian cells.

Cited by 6 publications

References 1 publication

Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits

Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits

A review of bioactive glasses: Their structure, properties, fabrication and apatite formation

Cisplatin delivery from nickel supported Al2O3 powders: characterization with swelling and mutagenity tests

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