Cytotoxicity of clove (<i>Syzygium aromaticum</i>) oil and its major components to human skin cells

Prashar, Anjali; Locke, Ian C.; Evans, Christine S.

doi:10.1111/j.1365-2184.2006.00384.x

Cited by 222 publications

(151 citation statements)

References 24 publications

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“…In this study significant variations were observed at higher concentrations (150 and 200 mg/l) of the clove extracts. This result support the findings of Prashar et al [41], in roach, (Rutilus rutilus) exposed to clove powder. These alterations in blood variables may be due to cytotoxicity of clove extracts at higher concentrations.…”

Section: Resultssupporting

confidence: 93%

The Efficacy of Clove Seed Extracts as an Anaesthetic Agent and Its Effect on Haematological Parameters of African Catfish (Clarias Gariepinus)

Akinrotimi¹

2015

Int J Aquac Fish Sci

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Background and Aim: The intensive nature of aquaculture has subjected fish to a number of stressors in the culture medium, anesthetics are widely used to minimize the issue of stress during farming operations and activities. Clove oil is a well known, established and acceptable anesthetics commonly used in aquaculture, this anesthetics is not readily available in developing countries, thus leaving the fish farmers with option of using the locally available plant extracts as anesthetic agent in fish culture. This study therefore assessed the efficacy of aqueous extracts of clove seed and its effect on hematological parameters of the fish.Methods: A total of 300 Clarias gariepinus comprises of 150 juveniles and 150 adult fish were exposed in triplicates to aqueous extracts of clove seed at concentrations of 5.0, 10.0, 15.0, 20.0 and 25.0mg/l at the rate of 10 fish per tank for both juveniles and adult fish. Induction time (Time taken for the fish to be completely anaesthetized) and recovery time (Time taken for the fish to resume normal swimming) was monitored using stop watch. Also, the effect of the extracts on water quality, survival and hematological parameters of the fish were evaluated using standard methods. Results:The result obtained revealed that the induction time indicated a size related response with the adult fish significantly (P<0.05) higher than the juveniles at all concentration of exposure. However, reverse was the case in recovery time, as the recover times in juveniles were higher than the adult fish. The survival was 100% in both sizes. Significant alterations were recorded in the haematological variables of the fish, which was more pronounced at higher concentrations of the extracts.

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Section: Resultssupporting

confidence: 93%

The Efficacy of Clove Seed Extracts as an Anaesthetic Agent and Its Effect on Haematological Parameters of African Catfish (Clarias Gariepinus)

Akinrotimi¹

2015

Int J Aquac Fish Sci

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“…These data are in agreement with the results from other studies (Prashar et al 2006). The major component of S. aromaticumis nomally considered to be eugenol, along with β-caryophyllene and lesser amounts of other components such as benzyl alcohol, however the proportions vary widely.…”

Section: Chemical Composition Of Crude Extractssupporting

confidence: 92%

Insecticidal Activity of Extracts Isolated from Syzygium Aromaticum

Jung¹,

Yang²

2014

Journal of the Korean Wood Science and Technology

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This study separated the crude extract (70% ethanol) of and its three fractions (hexane, chloroform and ethyl acetate extracts) on the basis of polarity indexes, and examined for their insecticidal activities against aphid (Uroleucon lactucicola). For crude extraction, the 70% ethanol extract showed the best extract yield (58.0%) and insecticidal activity (69.0%) among the various concentrations tested (water, 30% ethanol, 50% ethanol, 70% ethanol and 95% ethanol). The major chemical compounds of different fractions (hexane, chloroform and ethyl acetate extracts) were identified as eugenol by head space-GC-MS analysis. The hexane extract showed the highest eugenol content (43.7%) and insecticidal activity (80.0%). The insecticidal activity is accordingly believed to be attributable to the eugenol component. This may provide a useful starting point for the development of bio-pesticides.

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“…Clove oil was found to be highly cytotoxic at concentrations as low as 0.03% (v/v) with up to 73% of this effect attributable to EU. beta-caryophyllene did not exhibit any cytotoxic activity, indicating that other cytotoxic components may also exist within the parent oil [54]. Volatile oils display cytotoxic action toward the human tumor cell lines PC-3 and Hep G2 50 [55].…”

Section: Anticancer Activity Of Phenylpropanoids Eu Scaffold and Itsmentioning

confidence: 93%

“…In this way, Atsumi and collaborators [56] compared the cytotoxicity of dehydrodiiso EU 28, alpha-di-iso EU 29, iso EU, EU, and bis-EU 30 in a gland tumor cell line (HSG) and normal human gingival fibroblasts (HGF). These compounds against the salivary gland tumor cell line (HSG) and normal HGF were greatest in dehydrodiiso EU 27 and alpha-di-isoeugenol 28, followed by isoeugenol, which showed greater activity than EU [54]. , respectively, suggesting that the presence of nitro and hydroxyl groups could be important in the activity of these compounds [55].…”

Section: Anticancer Activity Of Phenylpropanoids Eu Scaffold and Itsmentioning

confidence: 99%

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

Fadilah

Yanuar²,

Arsianti³

et al. 2017

Asian J Pharm Clin Res

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Eugenol (EU) is a phenylpropene, an allyl chain-substituted guaiacol. EU is a member of the phenylpropanoids class of chemical compounds. It is a colorless to pale yellow oily liquid extracted from certain essential oils especially from clove oil. Further, chemopreventive agents might be used singly or in combination with chemotherapy or radiotherapy for the more effective treatment of cancer by enhancing the efficacy of these modalities with minimal side effects and toxicity. Considering that EU scaffold may be a prospective chemopreventive agent, its potent antitumor ability to interfere with solid cancer cell growth and its molecular mechanism were evaluated as an initiative toward the development of a novel strategy for cancer treatment. This review article will conduct that EU as the antiproliferative activity and molecular mechanism of the EU induced apoptosis against the cancer cells and animal models.

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Cytotoxicity of clove (Syzygium aromaticum) oil and its major components to human skin cells

Cited by 222 publications

References 24 publications

The Efficacy of Clove Seed Extracts as an Anaesthetic Agent and Its Effect on Haematological Parameters of African Catfish (Clarias Gariepinus)

The Efficacy of Clove Seed Extracts as an Anaesthetic Agent and Its Effect on Haematological Parameters of African Catfish (Clarias Gariepinus)

Insecticidal Activity of Extracts Isolated from Syzygium Aromaticum

Phenylpropanoids, Eugenol Scaffold, and Its Derivatives as Anticancer

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