Cytotoxicity of<i>Vinca minor</i>

Khanavi, Mahnaz; Pourmoslemi, Shabnam; Farahanikia, Behnaz; Hadjiakhoondi, Abbas; Ostad, Seyed Nasser

doi:10.3109/13880200903046187

Cited by 19 publications

(7 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, the combination of the two extracts could have led to the accumulation of a higher content of alkaloids and other phenolic compounds. As such compounds are known for cytotoxic activity [36][37][38], their internalization by keratinocytes along with the NPs could thus explain the high cytotoxicity of MNPs observed also on HaCaT and not just on A375 cells. Habas et al revealed an increase in LDH concentration in a dose-dependent manner [87], and Garvey et al observed no relation between LDH release and NP concentration, concluding that the assay could have interacted with the NPs [68].…”

Section: Mtt Assaymentioning

confidence: 99%

“…Due to their importance in clinical applications, the NPs are intensively investigated, and major progress was made in recent years on green synthesis techniques of nanomaterials and on assessing their biological effects on living organisms [3,4]. alkaloids for V. minor, such as vincamine [37,38]. The antitumor activity of these two plants has been thoroughly studied before in many in vitro and in vivo experiments [39][40][41][42], moreover, three Vinca alkaloids (vincristine, vinblastine, and vinorelbine) have been approved for use in cancer therapies in the United States [43].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

View full text Add to dashboard Cite

Medicinal plants are often used as reducing agents to prepare metal nanoparticles through green-synthesis due to natural compounds and their potential as chemotherapeutic drugs. Thus, three types of eco-friendly Ag-MnO2 nanoparticles (Ag-MnO2NPs) were synthesized using C. majus (CmNPs), V. minor (VmNPs), and a 1:1 mixture of the two extracts (MNPs). These NPs were characterized using S/TEM, EDX, XRD, and FTIR methods, and their biological activity was assessed in vitro on normal keratinocytes (HaCaT) and skin melanoma cells (A375). All synthesized NPs had manganese oxide in the middle, and silver oxide and plant extract on the exterior. The NPs had different forms (polygonal, oval, and spherical), uniformly distributed, with crystalline structures and different sizes (9.3 nm for MNPs; 10 nm for VmNPs, and 32.4 nm for CmNPs). The best results were obtained with VmNPs, which reduced the viability of A375 cells up 38.8% and had a moderate cytotoxic effect on HaCaT (46.4%) at concentrations above 500 µg/mL. At the same concentrations, CmNPs had a rather proliferative effect, whereas MNPs negatively affected both cell lines. For the first time, this paper proved the synergistic action of the combined C. majus and V. minor extracts to form small and uniformly distributed Ag-MnO2NPs with high potential for selective treatments.

show abstract

Section: Mtt Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The Vinca extracts had rather proliferative effects on HaCaT cells at concentrations between 0.09-2%, and inhibitory effects for the 3% concentration used. The obtained results could be explained by a dose-dependent cytotoxic effect on the cell lines [68]. The melanoma cells (A375) were negatively affected by all extracts in a dose-dependent manner as well, but V. herbacea and V. major var.…”

Section: Discussionmentioning

confidence: 85%

The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

et al. 2021

View full text Add to dashboard Cite

The phytochemical analysis of Vinca minor, V. herbacea, V. major, and V. major var. variegata leaf extracts showed species-dependent antioxidant, antibacterial, and cytotoxic effects correlated with the identified phytoconstituents. Vincamine was present in V. minor, V. major, and V. major var. variegata, while V. minor had the richest alkaloid content, followed by V. herbacea. V. major var. variegata was richest in flavonoids and the highest total phenolic content was found in V. herbacea which also had elevated levels of rutin. Consequently, V. herbacea had the highest antioxidant activity followed by V. major var. variegata. Whereas, the lowest one was of V. major. The V. minor extract showed the most efficient inhibitory effect against both Staphylococcus aureus and E. coli. On the other hand, V. herbacea had a good anti-bacterial potential only against S. aureus, which was most affected at morphological levels, as indicated by scanning electron microscopy. The Vinca extracts acted in a dose-depended manner against HaCaT keratinocytes and A375 melanoma cells and moreover, with effects on the ultrastructure, nitric oxide concentration, and lactate dehydrogenase release. Therefore, the Vinca species could be exploited further for the development of alternative treatments in bacterial infections or as anticancer adjuvants.

show abstract

“…The mechanism of action involves tubulin polymerization inhibition and microtubule dynamic behavior interference in targeted cells causing cell arrest and apoptosis [ 132 ]. Apoptosis in Vinca alkaloids involves a pathway independent cell arrest.…”

Section: Anticancer/cytotoxic Potential Of Alkaloids: Pharmacological...mentioning

confidence: 99%

“…Apoptosis in Vinca alkaloids involves a pathway independent cell arrest. Additionally, tubulin binding agents involve calmodulin and signal pathways perturbation along with phosphorylation of Bcl-2, Raf-1 kinase, Bcl-xL, and p53 [ 132 , 133 ]. Intracellular mitochondrial apoptosis is mediated by caspase-3 causing the breakdown of many cellular proteins.…”

Section: Anticancer/cytotoxic Potential Of Alkaloids: Pharmacological...mentioning

confidence: 99%

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

et al. 2022

View full text Add to dashboard Cite

Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.

show abstract

Cytotoxicity ofVinca minor

Cited by 19 publications

References 13 publications

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

Green Synthesis of Ag-MnO2 Nanoparticles using Chelidonium majus and Vinca minor Extracts and Their In Vitro Cytotoxicity

The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Contact Info

Product

Resources

About