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Medicinal plants are often used as reducing agents to prepare metal nanoparticles through green-synthesis due to natural compounds and their potential as chemotherapeutic drugs. Thus, three types of eco-friendly Ag-MnO2 nanoparticles (Ag-MnO2NPs) were synthesized using C. majus (CmNPs), V. minor (VmNPs), and a 1:1 mixture of the two extracts (MNPs). These NPs were characterized using S/TEM, EDX, XRD, and FTIR methods, and their biological activity was assessed in vitro on normal keratinocytes (HaCaT) and skin melanoma cells (A375). All synthesized NPs had manganese oxide in the middle, and silver oxide and plant extract on the exterior. The NPs had different forms (polygonal, oval, and spherical), uniformly distributed, with crystalline structures and different sizes (9.3 nm for MNPs; 10 nm for VmNPs, and 32.4 nm for CmNPs). The best results were obtained with VmNPs, which reduced the viability of A375 cells up 38.8% and had a moderate cytotoxic effect on HaCaT (46.4%) at concentrations above 500 µg/mL. At the same concentrations, CmNPs had a rather proliferative effect, whereas MNPs negatively affected both cell lines. For the first time, this paper proved the synergistic action of the combined C. majus and V. minor extracts to form small and uniformly distributed Ag-MnO2NPs with high potential for selective treatments.

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A novel metal-organic chain constructed of dysprosium and sodium ions based on 5-aminopyridine-2-carboxylic acid has been synthesized and characterized. The formation of this 1D-MOF is achieved using a soft solvothermal route with dimethylformamide as solvent. This material displays intense photoluminescence properties in the solid state at room temperature and exhibits SIM behavior with frequency dependence of the out-of-phase susceptibility at zero dc field. More interesting, we report here the magnetic field dependent cytotoxicity and multidrug-resistant properties of this 1D-MOF. This multidisciplinary preliminary study of the applications of this metal complex opens up the possibility of further investigations in the fields of metal-based drugs, luminescence and magnetism.