Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer

Lee, C.C.; Houghton, Peter J.

doi:10.1016/j.jep.2005.01.064

Cited by 199 publications

(141 citation statements)

References 12 publications

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“…This was mainly due to the protective or healing effects of natural products such as fruits, vegetables and spices [2,3]. Almost every time when the diverse biological activities of natural products are studied intensively; the significant bioactive molecules of herbs and spices display antioxidant, antiinflammatory, immunomodulatory, anticarcinogenic, antithrombotic, and anticoagulant effects [4][5][6]. Especially the antitumor activity of natural products has recently attracted considerable attention by synthetic chemists.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Papaver Somniferum

Güler¹,

Aydın²,

Koyuncu³

et al. 2016

J. Turk. Chem. Soc., Sect. A: Chem.

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Abstract:This work describes the pharmacological activity of extracts of Papaver somniferum L., a poppy species. P. somniferum L. products are still considered as a unique source of drug for many diseases. The present study was designed to determine antiproliferative and cytotoxic effects of P. somniferum L. extracts on HeLa (Human Cervix Carcinoma), HT29 (Human Colorectal Adenocarcinoma), C6 (Rat Brain Tumor Cells), and Vero (African Green Monkey Kidney) cell lines. Alkaloid-rich extracts of P. somniferum L. exhibited antiproliferative effects on various cancer cell lines, especially at high concentrations. We assessed the ability of extracts of P. somniferum L. to give harm to the membrane of the cells. Results indicated that P. somniferum L. extracts destroy cellular membrane in tumor cell lines at high concentrations. Remarkably, the LDH test results disclosed that cytotoxicity of P. somniferum L. on cells was low at middle concentrations. This may indicate its cytostatic potential. The results of this study support the efficacy of P. somniferum L. extracts as an anticancer agent.

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Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Papaver Somniferum

Güler¹,

Aydın²,

Koyuncu³

et al. 2016

J. Turk. Chem. Soc., Sect. A: Chem.

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“…It is worthy to mention the vivid current interest in discovery of natural drugs for cancer treatment and chemoprevention [4,5]. Huge number of plant species is screened and bioassayed for this purpose worldwide [6][7][8][9][10][11][12][13][14][15][16][17].…”

mentioning

confidence: 99%

Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7)

Abu-Dahab

2007

Sci Pharm

103

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“…For example, IC 50 of ARCE in COR-L23 cells, a lung cancer cell line, was 5.4-13.3 μg/ mL and IC 50 of ARCE in MCF7 cells, a breast cancer cell line, was 5.4-170 μg/mL. (26,27) ARCE was also reported to induce apoptosis in PC-3 cells, a prostate cancer cell line, in concentration of 100 μg/mL, 69% of total tested PC-3 cells were induced into apoptosis. (28) This suggested that ARCE has higher cytotoxic activity in cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Alpinia galanga Rhizome Crude Extract on NIH-3T3 Cells

et al. 2017

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B ACKGROUND:Alpinia galanga (A. galanga) was reported as a potential medicinal source due to its wide effect. A. galanga rhizome crude extract (ARCE) was reported to have high cytotoxic effect in cancer cells, but low in normal cells. However half maximal inhibitory concentration (IC 50 ) of ARCE is not clearly known yet. Hence, current study was conducted to investigate the IC 50 of ARCE in normal standard fibroblast cell line, NIH-3T3 cells. METHODS:Rhizomes of A. galanga were collected, peeled, dried, milled and weighed. Extraction was performed using maceration method, then filtered and evaporated. ARCE with various concentrations were applied in NIH-3T3 cells for 24 or 48 hours. Cells were documented and counted with 3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide (MTT) assay. RESULTS:Five hundreds grams of simplicia were macerated with ethanol and evaporated, 1 mg/mL crude extract with total volume of 114 mL was obtained. By addition of ARCE in NIH-3T3 cell culture, number of NIH-3T3 cells were shown less when treated with higher concentration of ARCE. Cell numbers of 0, 3.125, 6.25, 12.5, 25 and 50% ARCE treatment for 24 hours are 11, 531, 11,352, 10,920, 10,365, 9,471, 8,360, respectively, meanwhile for 48 hours are 13,219, 12,686, 12,278, 11,390, 10,279, 8,390, respectively. CONCLUSION: IC 50 of ARCE in 24 hours treatment was 620.5 mg/mL, while in 48 hours treatment was 666.6 mg/ mL. Hence, ARCE is suggested to have low cytotoxic effect in NIH-3T3 cells. KEYWORDS:

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Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer

Cited by 199 publications

References 12 publications

Anticancer Activity of Papaver Somniferum

Anticancer Activity of Papaver Somniferum

Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7)

Cytotoxicity of Alpinia galanga Rhizome Crude Extract on NIH-3T3 Cells

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