Cytotoxicity of Tamoxifen-Loaded Solid Lipid Nanoparticles

Abbasalipourkabir, Roghayeh; Salehzadeh, Aref; Abdullah, Rasedee

doi:10.5772/33521

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…In fact, apoptosis need not always be preceded by cell cycle arrest. For example, ethanol extract of the microalga Chaetoceros calcitrans, 31 tamoxifen-loaded solid lipid nanoparticles, 32 and avasimibe 33 can kill cells without halting their cell cycle. We then investigated the nature of the cell death.…”

Section: Discussionmentioning

confidence: 99%

“…Many potential nanotherapeutic particles, such as tamoxifen-loaded nanoparticles, are also known to kill cancer cells without a preceding cell cycle arrest. 32 There is a strong connection between metabolic insufficiency and cell death. For example, the proapoptotic Bcl-2 family proteins such as Bax and Bak are highly responsive to metabolic stress and can promptly execute apoptosis 58 in the presence of heightened metabolic stress.…”

Section: A Possible Relationship Between the Drug-induced Depletion O...mentioning

confidence: 99%

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Proteomic and metabolomic profiling combined with in vitro studies reveal the antiproliferative mechanism of silver nanoparticles in MDA-MB-231 breast carcinoma cells

2022

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Section: Discussionmentioning

confidence: 99%

Section: A Possible Relationship Between the Drug-induced Depletion O...mentioning

confidence: 99%

Proteomic and metabolomic profiling combined with in vitro studies reveal the antiproliferative mechanism of silver nanoparticles in MDA-MB-231 breast carcinoma cells

2022

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“…The results indicate the safety and biocompatibility of the formulations and free PZQ to eukaryotic cells. According to Abbasalipurkabir et al (2011), 39 the cytotoxicity effect of particles is due to their adherence to the cell membrane, particle internalization and degradation of products in the cell culture medium or inside the cells. However, the susceptibility of different cell types can be different for different particulate carriers.…”

Section: In Vitro Biological Assaysmentioning

confidence: 99%

Nanostructured Lipid Carriers as a Strategy to Improve the <I>In Vitro</I> Schistosomiasis Activity of Praziquantel

Kolenyak-Santos¹,

Garnero²,

Oliveira³

et al. 2015

j nanosci nanotechnol

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Praziquantel (PZQ) is a pyrazinoisoquinoline anthelmintic that was discovered in 1972 by Bayer Germany. Currently, due to its efficacy, PZQ is the drug of choice against all species of Schistosoma. Although widely used, PZQ exhibits low and erratic bioavailability because of its poor water solubility. Nanostructured lipid carriers (NLC), second-generation solid lipid nanoparticles, were developed in the 1990s to improve the bioavailability of poorly water soluble drugs. The aim of this study was to investigate nanostructured lipid carriers as a strategy to improve the efficacy of PZQ in S. mansoni treatment. We prepared NLC2 and NLC4 by adding seventy percent glycerol monostearate (GMS) as the solid lipid, 30% oleic acid (OA) as the liquid lipid and two surfactant systems containing either soybean phosphatidylcholine/poloxamer (PC/P-407) or phosphatidylcholine/Tween 60 (PC/T60), respectively. The carriers were characterized by nuclear magnetic resonance, differential scanning calorimetry, thermogravimetric analysis and Fourier transform-infrared spectroscopy. The safety profile was evaluated using red cell hemolysis and in vitro cytotoxicity assays. The results showed that the encapsulation of PZQ in NLC2 or NLC4 improved the safety profile of the drug. Treatment efficacy was evaluated on the S. mansoni BH strain. PZQ-NLC2 and PZQ-NLC4 demonstrated an improved efficacy in comparison with free PZQ. The results showed that the intestinal transport of free PZQ and PZQ-NLC2 was similar. However, we observed that the concentration of PZQ absorbed was smaller when PZQ was loaded in NLC4. The difference between the amounts of absorbed PZQ could indicate that the presence of T60 in the nanoparticles (NLC4) increased the rigid lipid matrix, prolonging release of the drug. Both systems showed considerable in vitro activity against S. mansoni, suggesting that these systems may be a promising platform for the administration of PZQ for treating schistosomiasis.

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“…Recently, tamoxifen was encapsulated in SLN (solid lipid nanoparticles) by highpressure homogenization. [34] In this method, SLN is first prepared and then the drug is encapsulated in it. The main ingredients in making SLN include solid lipid emulsifier and water.…”

Section: Breast Cancer Treatmentmentioning

confidence: 99%

A Review of the Effectiveness of Using Nanoparticles in the Treatment and Diagnosis of Breast Cancer

Kohli,

Mangla,

Haque

et al. 2024

Clin Cancer Investig J

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Cancer has been one of the main concerns of the health sector in recent years. The utilization of nanoparticles in medical science has created new possibilities for diagnosing, imaging tumors, and treating cancer in humans. This article reviews the utilization of inorganic and organic nanoparticles in cancer treatment and diagnosis. The method of gathering and summarizing the information was through the research conducted in connection with the structure of various types of nanoparticles and their application in imaging, diagnosis, and drug delivery systems in cancer treatment. From inorganic nanoparticles including quantum particles, which have a central core with magnetic attributes, for cancer imaging and detection, as well as from organic nanoparticle systems including dendrimers, aptamers, solid lipid nanoparticles, liposomes, and nanoparticles in transportation. Various drugs and ligands can be used. Aptamers are oligonucleotide or peptide molecules that bind to protein or target cells and are used in diagnosis, treatment, drug delivery, and molecular imaging. Also, nanobodies are antibody molecules that are widely utilized in cancer treatment and diagnosis. According to the obtained results, there are still limitations and challenges to the utilization of nanoparticles in medicine, however, it is vision that shortly nanoparticles will create a great revolution not only in oncology but also in medicine.

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Cytotoxicity of Tamoxifen-Loaded Solid Lipid Nanoparticles

Cited by 5 publications

References 38 publications

Proteomic and metabolomic profiling combined with in vitro studies reveal the antiproliferative mechanism of silver nanoparticles in MDA-MB-231 breast carcinoma cells

Proteomic and metabolomic profiling combined with in vitro studies reveal the antiproliferative mechanism of silver nanoparticles in MDA-MB-231 breast carcinoma cells

Nanostructured Lipid Carriers as a Strategy to Improve the <I>In Vitro</I> Schistosomiasis Activity of Praziquantel

A Review of the Effectiveness of Using Nanoparticles in the Treatment and Diagnosis of Breast Cancer

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