Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial drug-resistant cancer cells

Kuete, Victor; Mbaveng, Armelle T.; Zeino, Maen; Fozing, Christian D.; Ngameni, Bathélémy; Kapche, Gilbert Deccaux Wabo Fotso; Ngadjui, Bonaventure T.; Efferth, Thomas

doi:10.1016/j.phymed.2015.07.006

Cited by 72 publications

(46 citation statements)

References 33 publications

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“…Some documented caspase 3/7 activators included: benzophenones: guttiferone E ( 26 ) (Kuete et al, 2013d) and isoxanthochymol ( 30 ) from Garcinia punctata Oliv. (Kuete et al, 2013d), flavonoids: 4-hydroxylonchocarpin ( 7 ) and isobavachalcone ( 27 ) isolated from Dorstenia barteri Bureau (Kuete et al, 2011b, 2015c), 6,8-diprenyleriodictyol ( 8 ) isolated from Dorstenia mannii Hook.f. (Kuete et al, 2011b), cycloartocarpesin ( 18 ) from Morus mesozygia Stapf.…”

Section: Central Eastern and Western Africa Plants And Derived Molecmentioning

confidence: 99%

“…(Kuete et al, 2011b), cycloartocarpesin ( 18 ) from Morus mesozygia Stapf. (Kuete et al, 2015c), gancaonin Q ( 24 ) from Dorstenia angusticornis Engl. (Kuete et al, 2011b), isoflavonoids: 6α-hydroxyphaseollidin ( 9 ) from Erythrina sigmoidea Hua (Kuete et al, 2014c), isoneorautenol ( 29 ) from Erythrina excelsa Baker (Kuete et al, 2014d), xanthones: cudraxanthone I ( 17 ) from Milicia excelsa Welw C.C.…”

Section: Central Eastern and Western Africa Plants And Derived Molecmentioning

confidence: 99%

“…(Kuete et al, 2011d). Activators of initiator caspases 8 and 9 include benzophenone 26 (Kuete et al, 2013d) and 30 (Kuete et al, 2013d), flavonid 18 (Kuete et al, 2015c), isoflavonoid 9 (Kuete et al, 2014c), or xanthone 17 (Kuete et al, 2013b). …”

Section: Central Eastern and Western Africa Plants And Derived Molecmentioning

confidence: 99%

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Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets

Mbaveng

Kuete

Efferth³

2017

Front. Pharmacol.

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113

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Cancer remains a major health hurdle worldwide and has moved from the third leading cause of death in the year 1990 to second place after cardiovascular disease since 2013. Chemotherapy is one of the most widely used treatment modes; however, its efficiency is limited due to the resistance of cancer cells to cytotoxic agents. The present overview deals with the potential of the flora of Central, Eastern and Western African (CEWA) regions as resource for anticancer drug discovery. It also reviews the molecular targets of phytochemicals of these plants such as ABC transporters, namely P-glycoprotein (P-gp), multi drug-resistance-related proteins (MRPs), breast cancer resistance protein (BCRP, ABCG2) as well as the epidermal growth factor receptor (EGFR/ErbB-1/HER1), human tumor suppressor protein p53, caspases, mitochondria, angiogenesis, and components of MAP kinase signaling pathways. Plants with the ability to preferentially kills resistant cancer cells were also reported. Data compiled in the present document were retrieved from scientific websites such as PubMed, Scopus, Sciencedirect, Web-of-Science, and Scholar Google. In summary, plant extracts from CEWA and isolated compounds thereof exert cytotoxic effects by several modes of action including caspases activation, alteration of mitochondrial membrane potential (MMP), induction of reactive oxygen species (ROS) in cancer cells and inhibition of angiogenesis. Ten strongest cytotoxic plants from CEWA recorded following in vitro screening assays are: Beilschmiedia acuta Kosterm, Echinops giganteus var. lelyi (C. D. Adams) A. Rich., Erythrina sigmoidea Hua (Fabaceae), Imperata cylindrical Beauv. var. koenigii Durand et Schinz, Nauclea pobeguinii (Pobég. ex Pellegr.) Merr. ex E.M.A., Piper capense L.f., Polyscias fulva (Hiern) Harms., Uapaca togoensis Pax., Vepris soyauxii Engl. and Xylopia aethiopica (Dunal) A. Rich. Prominent antiproliferative compounds include: isoquinoline alkaloid isotetrandrine (51), two benzophenones: guttiferone E (26) and isoxanthochymol (30), the isoflavonoid 6α-hydroxyphaseollidin (9), the naphthyl butenone guieranone A (25), two naphthoquinones: 2-acetylfuro-1,4-naphthoquinone (4) and plumbagin (37) and xanthone V1 (46). However, only few research activities in the African continent focus on cytotoxic drug discovery from botanicals. The present review is expected to stimulate further scientific efforts to better valorize the African flora.

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Section: Central Eastern and Western Africa Plants And Derived Molecmentioning

confidence: 99%

Section: Central Eastern and Western Africa Plants And Derived Molecmentioning

confidence: 99%

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Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets

Mbaveng

Kuete

Efferth³

2017

Front. Pharmacol.

Self Cite

113

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“…Flavones and flavonols show in vitro anti-cancer activities to both human oesophageal adenocarcinoma and squamous cell carcinoma cells by inducting G2/M arrest and apoptosis (Zhang et al, 2008;Zhang et al, 2009). Artocarpesin, cycloartocarpesin, and isobavachalcone all have cytotoxic effects on the hepatocarcinoma HepG2, colon carcinoma HCT-116, leukemia CCRF-CEM, and other six cancer cells (Kuete et al, 2015). Following other four flavonoids quercetin, kaempferol, myricetin, and luteolin, apigenin (4',5,7-trihydroxyflavone) is one of the most common flavonoids in plant foods, and estimated to be consumed by Hungarian children and adults at 0.57-0.87 mg/day (Meyer et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Four in vitro activities of apigenin to human colorectal carcinoma cells susceptible to air-oxidative and heating treatments

Wang

Zhao

2017

Emir. J. Food Agric

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“…Recently Kuete et al evaluated the cytotoxic effects not only of the chalcone isobavachalcone but also of others two flavonoids, artocarpesin and cycloartocarpesin, on drug-sensitive cancer cell lines and, for the first time, against MDR cancer cell lines. In particular, they demonstrated that these compounds induce, on MDR leukemia cells CCRF-CEM, apoptosis through activation of caspases, disruption of mitochondrial membrane potential and generation of reactive oxygen species (ROS) [32].…”

Section: Flavonoidsmentioning

confidence: 99%

Natural Compounds: Molecular Weapons against Leukemia’s

Taverna¹,

Corrado

2017

J Leuk

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Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones.A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis.Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.

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Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial drug-resistant cancer cells

Cited by 72 publications

References 33 publications

Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets

Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets

Four in vitro activities of apigenin to human colorectal carcinoma cells susceptible to air-oxidative and heating treatments

Natural Compounds: Molecular Weapons against Leukemia’s

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