Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry

Sun, Hainan; Jiang, Cuijuan; Li-jun, WU; Bai, Xue; Zhai, Shumei

doi:10.3389/fbioe.2019.00414

Cited by 92 publications

(71 citation statements)

References 166 publications

(193 reference statements)

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“…In terms of cell internalization, it is well documented that SPIONs can accumulate in large amounts inside the cell, both in cancer cells and in normal cells [61,62]. Our hypothesis is that the coating and functionalization of the nanoformulations increase their hydrophilicity and therefore their dispersion [63], and reduce the interactions between particles [50], allowing a greater number of nanoformulations to be available for cell internalization, which previously remained agglutinated. A greater amount of NPs (and thus, also iron) inside the cell increases migration capacity.…”

Section: Discussionmentioning

confidence: 91%

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

et al. 2020

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Current chemotherapy for colorectal cancer (CRC) includes the use of oxaliplatin (Oxa), a first-line cytotoxic drug which, in combination with irinotecan/5-fluorouracil or biologic agents, increases the survival rate of patients. However, the administration of this drug induces side effects that limit its application in patients, making it necessary to develop new tools for targeted chemotherapy. MamC-mediated biomimetic magnetic nanoparticles coupled with Oxa (Oxa-BMNPs) have been previously demonstrated to efficiently reduce the IC50 compared to that of soluble Oxa. However, their strong interaction with the macrophages revealed toxicity and possibility of aggregation. In this scenario, a further improvement of this nanoassembly was necessary. In the present study, Oxa-BMNPs nanoassemblies were enveloped in phosphatidylcholine unilamellar liposomes (both pegylated and non-pegylated). Our results demonstrate that the addition of both a lipid cover and further pegylation improves the biocompatibility and cellular uptake of the Oxa-BMNPs nanoassemblies without significantly reducing their cytotoxic activity in colon cancer cells. In particular, with the pegylated magnetoliposome nanoformulation (a) hemolysis was reduced from 5% to 2%, being now hematocompatibles, (b) red blood cell agglutination was reduced, (c) toxicity in white blood cells was eliminated. This study represents a truly stepforward in this area as describes the production of one of the very few existing nanoformulations that could be used for a local chemotherapy to treat CRC.

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Section: Discussionmentioning

confidence: 91%

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

et al. 2020

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“…The published literature provides numerous examples that the surface chemistry of NPs, and properties such as surface charge are able to affect the amount of ROS generated by NPs. [221,222] For example, positively charged Si NP-NH 2 proved to be more cytotoxic in terms of reducing mitochondrial metabolic activity and effects on phagocytosis than neutral Si NP-N3 because positively charged Si NP-NH 2 were found to produce the highest level of intracellular ROS. [223] Iron oxide NPs coated with positively charged chitosan were reported to produce abundant ROS, underpinning their significant antimicrobial activity against Escherichia coli and Bacillus subtilis.…”

Section: Effects Of Surface Functionalization and Coatings On Ros Genmentioning

confidence: 99%

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies. Similar to photodynamic therapy but suitable for large and deep tumors, this new approach where nanomaterials acting as sensitizing agents are combined with clinical radiation can be effective at well‐tolerated low radiation doses. Suitably engineered nanomaterials can enhance cancer radiotherapy by increasing the tumor selectivity and decreasing side effects. Additionally, the nanomaterial platform offers therapeutically valuable functionalities, including molecular targeting, drug/gene delivery, and adaptive responses to trigger drug release. The potential of such nanomaterials to be combined with radiotherapy is widely recognized. In order for further breakthroughs to be made, and to facilitate clinical translation, the applicable principles and fundamentals should be articulated. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways to optimize its therapeutic efficacy. A roadmap for designing nanomaterials with optimized anticancer performance is also shown and the potential clinical significance and future translation are discussed.

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“…The low metabolic activity in cancer cells is due to interaction of positive potential (zeta potential) on aminated cellulose derivatives with negative charge on cell membrane [ 55 , 62 ]. Thus, depolarization of membrane and imbalance in ionic transport occurred [ 63 ]. An alteration in cell signal stimulates the mitochondria to generate intracellular oxidation stress, thereby decreasing metabolic activity of cells.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization and Cytotoxicity Studies of Aminated Microcrystalline Cellulose Derivatives against Melanoma and Breast Cancer Cell Lines

Nazir

Iqbal

2020

Polymers

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Cellulose based materials are emerging in the commercial fields and high-end applications, especially in biomedicines. Aminated cellulose derivatives have been extensively used for various applications but limited data are available regarding its cytotoxicity studies for biomedical application. The aim of this study is to synthesize different 6-deoxy-amino-cellulose derivatives from Microcrystalline cellulose (MCC) via tosylation and explore their cytotoxic potential against normal fibroblasts, melanoma and breast cancer. 6-deoxy-6-hydrazide Cellulose (Cell Hyd) 6-deoxy-6-diethylamide Cellulose (Cell DEA) and 6-deoxy-6-diethyltriamine Cellulose (Cell DETA) were prepared and characterized by various technologies like Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), nuclear magnetic resonance spectroscopy (NMR), X-ray diffractogram (XRD), Scanning Electron microscopy (SEM), Elemental Analysis and Zeta potential measurements. Cytotoxicity was evaluated against normal fibroblasts (NIH3T3), mouse skin melanoma (B16F10), human epithelial adenocarcinoma (MDA-MB-231) and human breast adenocarcinoma (MCF-7) cell lines. IC50 values obtained from cytotoxicity assay and live/dead assay images analysis showed MCC was non cytotoxic while Cell Hyd, Cell DEA and Cell DETA exhibited noncytotoxic activity up to 200 μg/mL to normal fibroblast cells NIH3T3, suggesting its safe use in medical fields. The mouse skin melanoma (B16F10) are the most sensitive cells to the cytotoxic effects of Cell Hyd, Cell DEA and Cell DETA, followed by human breast adenocarcinoma (MCF-7). Based on our study, it is suggested that aminated cellulose derivatives could be promising candidates for tissue engineering applications and in cancer inhibiting studies in future.

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Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry

Cited by 92 publications

References 166 publications

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Synthesis, Characterization and Cytotoxicity Studies of Aminated Microcrystalline Cellulose Derivatives against Melanoma and Breast Cancer Cell Lines

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