2001
DOI: 10.1177/026119290102900319
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Cytotoxicity Testing of Wound-Dressing Materials

Abstract: A method was developed for testing the cytotoxicity of various bandage-like wound dressings and gel wound dressings. In this method, the ability of human polymor-phonuclear neutrophils (PMNs) to initiate a respiratory burst after exposure to the various wound dressings is used as a marker of cytotoxicity. Luminol-amplified chemiluminescence stimulated with opsonised zymosan or phorbol 12-myristate 13-acetate (PMA) is used to measure the degree of activation of the respiratory burst, i.e. the NADPH oxidase acti… Show more

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Cited by 3 publications
(2 citation statements)
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“…As indicated in Figure S3 in the Supporting Information, the morphologies of L929 cells incubated in the extract substrates of the SE‐0.10 membranes all show spindle, triangular, and quadrangular shapes with good growing conditions. According to the standard of cytotoxicity ranking in the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) assay, the cytotoxicity grade of the SE‐0.10 material is attributed as Grade 1. Taken together, these results indicate that the SE‐0.10 material is non‐cytotoxic and demonstrate high potential for further utilization of the material in biological applications, such as carriers for drug delivery.…”
Section: Resultsmentioning
confidence: 99%
“…As indicated in Figure S3 in the Supporting Information, the morphologies of L929 cells incubated in the extract substrates of the SE‐0.10 membranes all show spindle, triangular, and quadrangular shapes with good growing conditions. According to the standard of cytotoxicity ranking in the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) assay, the cytotoxicity grade of the SE‐0.10 material is attributed as Grade 1. Taken together, these results indicate that the SE‐0.10 material is non‐cytotoxic and demonstrate high potential for further utilization of the material in biological applications, such as carriers for drug delivery.…”
Section: Resultsmentioning
confidence: 99%
“…Fourteen days after intragastric administration [24], no abnormalities in body weight, or changes in behavior or histopathology were observed for the Kunming mice (Figure 4). It appears that the 0.5 wt% CNC suspension is not cytotoxic.…”
Section: Cytotoxicity Testingmentioning
confidence: 97%