Cząsteczki mikroRNA jako istotny składnik mechanizmów regulacji ekspresji genów związanych z nowotworami

Budzynski, M.; Grenda, Anna; Filip, Agata

doi:10.5603/njo.2014.0007

Cited by 6 publications

(7 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The risk of developing breast (or ovarian) cancer in carriers of mutations in these tumor suppressor genes is significantly higher than in non-carriers. Precisely, in the general population, about 13% of women will eventually develop breast cancer [24], while 55-72% of women who inherit a harmful BRCA1 variant and 45-69% of women who inherit a harmful BRCA2 variant will develop breast cancer by 70-80 years of age [25][26][27]. Noteworthy, the risk depends on several factors, some of which have not been fully characterized.…”

Section: Breast Cancer Treatment Strategies Based On Molecular Charac...mentioning

confidence: 99%

miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy

Dziechciowska,

Dąbrowska,

Mizielska

et al. 2023

CIMB

View full text Add to dashboard Cite

Breast cancer is one of the most commonly diagnosed cancer types worldwide. Regarding molecular characteristics and classification, it is a heterogeneous disease, which makes it more challenging to diagnose. As is commonly known, early detection plays a pivotal role in decreasing mortality and providing a better prognosis for all patients. Different treatment strategies can be adjusted based on tumor progression and molecular characteristics, including personalized therapies. However, dealing with resistance to drugs and recurrence is a challenge. The therapeutic options are limited and can still lead to poor clinical outcomes. This review aims to shed light on the current perspective on the role of miRNAs in breast cancer diagnostics, characteristics, and prognosis. We discuss the potential role of selected non-coding RNAs most commonly associated with breast cancer. These include miR-21, miR-106a, miR-155, miR-141, let-7c, miR-335, miR-126, miR-199a, miR-101, and miR-9, which are perceived as potential biomarkers in breast cancer prognosis, diagnostics, and treatment response monitoring. As miRNAs differ in expression levels in different types of cancer, they may provide novel cancer therapy strategies. However, some limitations regarding dynamic alterations, tissue-specific profiles, and detection methods must also be raised.

show abstract

Section: Breast Cancer Treatment Strategies Based On Molecular Charac...mentioning

confidence: 99%

miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy

Dziechciowska,

Dąbrowska,

Mizielska

et al. 2023

CIMB

View full text Add to dashboard Cite

show abstract

“…It is believed that up to 30% of protein-coding genes can be regulated by the corresponding miRNAs. The microRNAs are "guardians" that take care of the proper course of processes such as cell division, proliferation, differentiation or cell apoptosis, which are of fundamental importance for the proper functioning of the body [12].…”

Section: Microrna (Mirna)mentioning

confidence: 99%

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in endometriosis — review of literature

Szaflik,

Romanowicz,

Szyllo

et al. 2023

Ginekol Pol

View full text Add to dashboard Cite

Endometriosis is a disease of the female genital organs, the causes of which are not fully understood. Recent studies have shown that non-coding RNAs (ncRNAs) like long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) can contribute to the pathogenesis of endometriosis. Profiling of miRNA and lncRNA expression is carried out using state-of-the-art molecular biology techniques (RT-PCR, sequencing, microarray analysis). The use of the latest technologies may make it possible to establish a genetic profile, which is a promising prospect for early diagnosis of endometriosis. In the future, genetic testing may become the gold diagnostic standard and eliminate invasive laparoscopy. In the case of endometriosis, it is important to extend the research to molecular aspects, which may facilitate the diagnosis of the disease or indicate new (based for example ncRNA) treatment methods. The paper presents the latest data on the importance of miRNA/lncRNA in endometriosis.

show abstract

“…These processes include cell division, proliferation, differentiation, cell apoptosis, as well as blood vessel formation, or, finally, neoplasm [28]. The altered expression of individual miRNAs has been demonstrated in a number of cancers, which may indicate the oncogenic or suppressive potential of the molecules [28,29].…”

Section: Microrna-structure and Functionmentioning

confidence: 99%

The Role of microRNA in Pancreatic Cancer

et al. 2021

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are small ribonucleic acid molecules that play a key role in regulating gene expression. The increasing number of studies undertaken on the functioning of microRNAs in the tumor formation clearly indicates their important potential in oncological therapy. Pancreatic cancer is one of the deadliest cancers. The expression of miRNAs released into the bloodstream appears to be a good indicator of progression and evaluation of the aggressiveness of pancreatic cancer, as indicated by studies. The work reviewed the latest literature on the importance of miRNAs for pancreatic cancer development.

show abstract

Cząsteczki mikroRNA jako istotny składnik mechanizmów regulacji ekspresji genów związanych z nowotworami

Cited by 6 publications

References 72 publications

miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy

miRNA Expression Profiling in Human Breast Cancer Diagnostics and Therapy

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in endometriosis — review of literature

The Role of microRNA in Pancreatic Cancer

Contact Info

Product

Resources

About