d-allulose protects against diabetic nephropathy progression in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes

Niibo, Misato; Kanasaki, Akane; Iida, Takuya; Ohnishi, Keisuke; Ozaki, Taro; Akimitsu, Kazuya; Minamino, Tetsuo

doi:10.1371/journal.pone.0263300

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…D-Psicose, a newly applied sweetener, has been defined by multiple previous studies as an ingredient with beneficial physiological effects on obesity and type 2 diabetes [22,23]. However, some clinical cohort studies have confirmed that the D-psicose intake may cause some gastrointestinal disorders [24].…”

Section: Discussionmentioning

confidence: 99%

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

Zhang¹,

Li²,

Wang³

et al. 2024

Food Science and Human Wellness

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D-Psicose, as a low-calorie rare sugar, has attracted a lot of attention in recent years for alternating to sucrose. The anti-obesity effect of D-psicose has been extensively confirmed in previous studies, however, the impact of D-psicose on colitis remains vague. Here, we firstly evaluated the effect of the D-psicose prophylactic intervention on dextran sulfate sodium-induced colitis in C57BL/6 mice. The pathological symptoms, inflammatory cytokines levels, gut microbiota composition, short chain fatty acids (SCFAs) production and colonic barrier integrity were comprehensively evaluated. The results confirmed that D-psicose intervention aggravated colitis, characterized by the exacerbation of colon shortening, increase of colonic inflammatory infiltration, and marked exaltation of disease activity indices and IL-6, IL-1β and TNF-α levels. Further, the dysfunction of gut microbiota was identified in the psicose group. The abundance of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated while the abundance of probiotics Akkermansia and Lactobacillus were significantly down-regulated in the psicose group compared to the model group. Moreover, the production of SCFAs was suppressed in the psicose group, accompanied by a decrease in the level of mucin 2 (Muc-2). Collectively, the underlying mechanism of the exacerbation of colitis by D-psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of SCFAs, which leads to the damage of the mucosal barrier and the intensification of inflammatory invasion.

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Section: Discussionmentioning

confidence: 99%

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

Zhang¹,

Li²,

Wang³

et al. 2024

Food Science and Human Wellness

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“…Therefore, D-allulose can be used as a sweetener in controlling a body weight diet. It is recommended for people with diabetes since it does not affect insulin [ 110 ] and does not significantly attenuate the increase of glucose levels in the blood [ 111 ] (which allows for glycemic control). Moreover, it is tooth-friendly, in contrast to sugar.…”

Section: Techniques Used In Reducing the Sugar Content Of Juicesmentioning

confidence: 99%

Application of Emerging Techniques in Reduction of the Sugar Content of Fruit Juice: Current Challenges and Future Perspectives

Cywińska-Antonik

Chen

Groele³

et al. 2023

Foods

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In light of the growing interest in products with reduced sugar content, there is a need to consider reducing the natural sugar concentration in juices while preserving the initial concentration of nutritional compounds. This paper reviewed the current state of knowledge related to mixing juices, membrane processes, and enzymatic processes in producing fruit juices with reduced concentrations of sugars. The limitations and challenges of these methods are also reviewed, including the losses of nutritional ingredients in membrane processes and the emergence of side products in enzymatic processes. As the existing methods have limitations, the review also identifies areas that require further improvements and technological innovations.

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“…Overall, our result supports another evidence that D-allulose plays a beneficial role not only as a chemical sweetener but also gives pharmacological support as an anti-diabetic, probably through its chemical structure as a mimetic sugar bypassing the pancreatic and insulin functions and through its functional structure as an insulin mimetic and modulator of some insulin-responsive genes. 17 Furthermore, D-allulose possesses antiatherogenic property, 17 a metabolic regulator of glucose and lipid metabolism, 18,19 a regulator of postprandial glucose metabolism 20 and is a regulator of muscular glucose disposal. 21 In addition, administration of 25 g of D-allulose did not change blood lipids, uric acid, or hsCR, making D-allulose an excellent, effective, and safe sugar substitute.…”

Section: Role Of D-allulose Treatment On Blood Glucose Levelmentioning

confidence: 99%

“…15 Iida et al further validated the role of acute D-allulose administration in decreasing glycemic responses induced by maltodextrin in normal adults. 16 Conclusively, the potential medicinal role of Dallulose varies from its role as an insulin mimetic and modulator of some insulin-responsive genes, 17 as an anti-atherogenic property, 17 as the metabolic regulator of glucose and lipid metabolism, 18,19 as a regulator of postprandial glucose metabolism 20 and as a regulator of muscular glucose disposal. 21 Considering recent advances, D-allulose may play a beneficial role as a sweetener or sugar substitute as well as a pharmacologic treatment for diabetic conditions.…”

Section: Introductionmentioning

confidence: 99%

The Potential Effect of Honey-derived D-Allulose in Counteracting Hyperglycemia by Time and Dose Dependent Manner in Diabetes Mellitus

Sari

2023

Valensi

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Diabetes mellitus has become a worldwide burden due to its persistent, chronic hyperglycemia. D-allulose, a monosaccharide sugar with a 180.16 molecular weight, is widely used as a low-calorie sweetener, is not involved in glucose-related metabolism, and thus does not alter insulin and pancreatic function. This study aimed to evaluate the potential role of honey-derived D-allulose in acute and sub-chronic diabetes mellitus. Diabetic Sprague-Dawley rats were divided into 9 groups and treated with 0.1, 0.2, and 0.4 g/kg BW honey-derived D-allulose for 28, 56, and 84 days. Post-prandial blood glucose levels and body weight were measured every 4 weeks. Significant reductions in post-prandial blood glucose levels were observed on days 56 and 84 treatment with 0.1 g/kg BW D-allulose. More significant reductions were observed on days 28, 56, and 84 of treatment with 0.2 or 0.4 g/kg BW D-allulose. Eighty-four days of treatment with 0.4 g/kg BW D-allulose significantly reduced post-prandial blood glucose levels compared to all groups. We identified that honey-derived D-allulose reduced post-prandial blood glucose levels in a dose- and time-dependent manner. Thus, honey-derived D-allulose may provide beneficial support for diabetic conditions not only as a sweetener but also as a pharmacological treatment.

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d-allulose protects against diabetic nephropathy progression in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes

Cited by 9 publications

References 36 publications

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

Application of Emerging Techniques in Reduction of the Sugar Content of Fruit Juice: Current Challenges and Future Perspectives

The Potential Effect of Honey-derived D-Allulose in Counteracting Hyperglycemia by Time and Dose Dependent Manner in Diabetes Mellitus

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