d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats

Pongkan, Wanpitak; Jinawong, Kewarin; Pratchayasakul, Wasana; Jaiwongkam, Thidarat; Kerdphoo, Sasiwan; Tokuda, Masaaki; Chattipakorn, Nipon

doi:10.1007/s00394-020-02394-y

Cited by 19 publications

(14 citation statements)

References 49 publications

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“…Notably, the HE-clamp showed similar insulin sensitivity between the HFA and standard CD groups, despite the presence of higher visceral fat in the HFA group than in the CD group. Our results are consistent with those of others demonstrating that D-allulose in drinking water improves insulin sensitivity without affecting body weight or fat mass [15,16], indicating its mechanism is independent of weight loss or fat reduction. In the two-step HE-clamp test, low-dose insulin infusion GIR refers to insulin sensitivity of the liver and peripheral tissues [17], whereas high-dose insulin infusion GIR refers to the insulin sensitivity index of the skeletal muscle [18].…”

Section: Discussionsupporting

confidence: 93%

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

et al. 2021

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Background: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. Objective: This study aimed to investigate the effect of d-allulose on high-fat diet (HFD)-induced insulin resistance using the hyperinsulinemic–euglycemic (HE)-clamp method and intramuscular signaling analysis. Methods: Wistar rats were randomly divided into three dietary groups: chow diet, HFD with 5% cellulose (HFC), and HFD with 5% d-allulose (HFA). After four weeks of feeding, the insulin tolerance test (ITT), intraperitoneal glucose tolerance test (IPGTT), and HE-clamp study were performed. The levels of plasma leptin, adiponectin, and tumor necrosis factor (TNF)-α were measured using the enzyme-linked immunosorbent assay. We analyzed the levels of cell signaling pathway components in the skeletal muscle using Western blotting. Results: d-allulose alleviated the increase in HFD-induced body weight and visceral fat and reduced the area under the curve as per ITT and IPGTT. d-Allulose increased the glucose infusion rate in the two-step HE-clamp test. Consistently, the insulin-induced phosphorylation of serine 307 in the insulin receptor substrate-1 and Akt and expression of glucose transporter 4 (Glut-4) in the muscle were higher in the HFA group than HFC group. Furthermore, d-allulose decreased plasma TNF-α concentration and insulin-induced phosphorylation of stress-activated protein kinase/Jun N-terminal kinase in the muscle and inhibited adiponectin secretion in HFD-fed rats. Conclusions: d-allulose improved HFD-induced insulin resistance in Wistar rats. The reduction of the proinflammatory cytokine production, amelioration of adiponectin secretion, and increase in insulin signaling and Glut-4 expression in the muscle contributed to this effect.

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Section: Discussionsupporting

confidence: 93%

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

et al. 2021

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“…A clearer understanding of the absorption and metabolism of rare sugars in humans, their effects when consumed in realistic doses as part of reformulated foods, and their mechanisms of action, is vital when considering the potential benefits of rare sugars in the human diet. Hayashi 2010 (28) Noronha 2018 (29) Kwak 2013 (33) PSI RSS Matsuo 2011 (30) #* Yamada 2018 (31) #* Iida 2008 (32) # Nakamura 2017 (34) #* PSI Hossain 2011 (43) , 2012 (59) Iwasaki 2018 (51) Pongkan 2020 (64) SOR RSS Oku 2014 (25) Shintani 2017 (74) Improved longterm glycaemic control TAG Ensor 2014 (38) , 2015 (40) PSI Baek 2010 (58) Do 2019 (41) + Han 2016 (42) Hossain 2011 (43) . 2012 (59) .…”

Section: Discussionmentioning

confidence: 99%

“…Of these, three found no significant differences in blood glucose or insulin with PSI (61; 62) or RSS (63) feeding. Reductions in fasting blood glucose were reported in two studies feeding PSI to mice with diet-induced obesity (DIO) (41; 42) , and Pongkan et al (64) , found significant reductions in fasting insulin levels and insulin resistance when PSI was fed to obese Wistar rats. Of the four studies in which there was no metabolic disorder, two reported a reduction in insulin levels with PSI (65) or RSS (66) , with Iida et al also reporting reduced fasting blood glucose (66) .…”

Section: Rare Sugars and Glycaemic Controlmentioning

confidence: 97%

Rare sugars: metabolic impacts and mechanisms of action: a scoping review

et al. 2021

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Food manufacturers are under increasing pressure to limit the amount of free sugars in their products. Many have reformulated products to replace sucrose, glucose and fructose with alternative sweeteners, but some of these have been associated with additional health concerns. Rare sugars are “monosaccharides and their derivatives that hardly exist in nature”, and there is increasing evidence that they could have health benefits. This review aimed to scope the existing literature in order to identify the most commonly researched rare sugars, to ascertain their proposed health benefits, mechanisms of action and potential uses, and to highlight knowledge gaps. A process of iterative database searching identified 55 relevant articles. The reported effects of rare sugars were noted, along with details of the research methodologies conducted. Our results indicated that the most common rare sugars investigated are D-psicose and D-tagatose, with the potential health benefits divided into three topics: glycaemic control, body composition and cardiovascular disease. All the rare sugars investigated have the potential to suppress postprandial elevation of blood glucose and improve glycaemic control in both human and animal models. Some animal studies have suggested that certain rare sugars may also improve lipid profiles, alter the gut microbiome and reduce pro-inflammatory cytokine expression. The present review demonstrates that rare sugars could play a role in reducing the development of obesity, type 2 diabetes, and/or cardiovascular disease. However, understanding of the mechanisms by which rare sugars may exert their effects is limited, and their effectiveness when used in reformulated products is unknown.

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“…Furthermore, Ochiai et al showed that D-allulose increases resting energy expenditure in HSD-fed rats and contributes to reducing body weight [8]. Notably, recent reports using drinking water containing D-allulose showed improvement in insulin sensitivity in rats fed with a high-fat diet without affecting their body weights or fat masses, indicating that the mechanisms involved are independent of body weight or fat reduction [37,38].…”

Section: Discussionmentioning

confidence: 99%

Investigation of d-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats

Natsume

Yamada

Iida

et al. 2021

Heliyon

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d -Allulose, a C-3 epimer of d -fructose, is a rare sugar that has no calories. Although d- allulose has been reported to have several health benefits, such as anti-obesity and anti-diabetic effects, there have been no reports evaluating the effects of d- allulose on insulin resistance using a hyperinsulinemic-euglycemic clamp (HE-clamp). Therefore, we investigated the effects of d- allulose on a high-sucrose diet (HSD)-induced insulin resistance model. Wistar rats were randomly divided into three dietary groups: HSD containing 5% cellulose (HSC), 5% d- allulose (HSA), and a commercial diet. The insulin tolerance test (ITT) and HE-clamp were performed after administration of the diets for 4 and 7 weeks. After 7 weeks, the muscle and adipose tissues of rats were obtained to analyze Akt signaling via western blotting, and plasma adipocytokine levels were measured. ITT revealed that d- allulose ameliorated systemic insulin resistance. Furthermore, the results of the 2-step HE-clamp procedure indicated that d- allulose reversed systemic and muscular insulin resistance. d- Allulose reversed the insulin-induced suppression of Akt phosphorylation in the soleus muscle and epididymal fat tissues and reduced plasma TNF-α levels. This study is the first to show that d- allulose improves systemic and muscle insulin sensitivity in conscious rats.

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d-allulose provides cardioprotective effect by attenuating cardiac mitochondrial dysfunction in obesity-induced insulin-resistant rats

Cited by 19 publications

References 49 publications

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats

Rare sugars: metabolic impacts and mechanisms of action: a scoping review

Investigation of d-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats

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