D-dimer identifies stages in the progression of diabetes mellitus from family history of diabetes to cardiovascular complications

Nwose, Ezekiel Uba; Richards, Ross S.; Jelinek, Herbert F.; Kerr, Philip G.

doi:10.1080/00313020701230658

Cited by 46 publications

(49 citation statements)

References 26 publications

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“…Nwose et al 64 reported changes in D-dimer levels in DM progression to macrovascular complications, as was earlier stated. Coban et al 65 reported significantly higher plasma D-dimer levels in patients with impaired fasting glucose.…”

Section: D-dimersupporting

confidence: 57%

“…Nwose et al 64 investigate the possible discriminatory potential of D-dimer in identifying the variations in the fibrinolytic and/or coagulation component of diabetesassociated with disease progression to macrovascular complications. They report that the changes in D-dimer levels may indicate diabetes disease progression to macrovascular complications and that using D-dimer in conjunction with other biomarkers may identify stages of disease progression.…”

Section: D-dimermentioning

confidence: 99%

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Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Agu

2018

JMH

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Background: The WHO defined ‘diabetes mellitus’ (DM) as a metabolic disorder characterised by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from the defect in insulin secretion, or inaction, or both. When not identified early and controlled, acute and chronic life-threatening consequences may result. Identifying DM early for treatment and management, as well as clinically monitoring recovery and improvement during treatment, involves the assessments of biomarkers. The types, choice, sensitivity and descriptive information trends of these biomarkers are very important. Aim: Some prognostic biomarkers and parameters that this review identified include glycated haemoglobin, white blood cells, mean neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, total leukocytes and neutrophils, plasma low-density lipoprotein, high-density lipoprotein and very low-density lipoprotein, platelet, fibrinogen, D-dimer and C-reactive proteins. Results: These parameters display increases in DM, while red blood cell, haemoglobin concentration, activated partial thromboplastin time, prothrombin time and partial thromboplastin time are decreased. Conclusion: With sound knowledge of the variations of these markers and parameters, observed reversal during treatment and management of DM and its complications can be better monitored, and guided decisions can be made.

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Section: D-dimersupporting

confidence: 57%

Section: D-dimermentioning

confidence: 99%

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Agu

2018

JMH

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“…Studies have shown that markers of coagulation such as D-dimer and C5a are increased in diabetes and obesity [23][24][25][26]. D-dimer is a product of fibrin degradation and its level has been related to lower levels of reduced glutathione (GSH) [23,24,27].…”

Section: Introductionmentioning

confidence: 99%

“…D-dimer is a product of fibrin degradation and its level has been related to lower levels of reduced glutathione (GSH) [23,24,27]. An increase in oxidative stress first leads to a depletion in GSH followed by a rebound increase [28].…”

Section: Introductionmentioning

confidence: 99%

“…An increase in oxidative stress first leads to a depletion in GSH followed by a rebound increase [28]. The decrease in GSH observed closer to the onset of T2DM is due to the activity of plasminogen activator inhibitor-1 (PAI-1) and thrombin-activated fibrinolysis inhibitor (TAFI), followed by an increase in erythrocyte GSH levels associated with erythrocyte oxidative stress [23,24,27]. However, during T2DM disease progression, the physiological response to GSH synthesis/ regeneration is overwhelmed by continued oxidative stress due to free radical activity, which leads eventually to a decrease in GSH concentration and an increase in D-dimer levels [23,27].…”

Section: Introductionmentioning

confidence: 99%

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Diabesity Increases Inflammation and Oxidative Stress

A¹,

Pouvreau²,

Eg³

et al. 2016

Int J Pharm Sci Dev Res

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Background: Inflammation and oxidative stress are two pathophysiological mechanisms that link obesity, type 2 diabetes mellitus (T2DM) and diabesity. However how levels of inflammatory and oxidative stress markers differ between patients with obesity, T2DM and diabesity has not been completely elucidated.Objectives: This study aimed to investigate the interactions between emerging biomarkers of oxidative stress and inflammation and the differences in biomarker levels between T2DM, obesity and diabesity in a clinical setting. Methods:A total of 270 patients attending a diabetes health screening clinic (57 T2DM; 37 obese; 44 diabesity, and 132 age, gender, and weight-matched controls) participated in the study. All patients were selected on clinical grounds. Differences in the level of biomarkers of oxidative stress (erythrocyte GSH/GSSG, 8-hydroxy-2-deoxy-guanosine (8-OHdG) and urinary 8-iso-prostaglandin F 2α ), inflammation (CRP, IL-6, IL-10 and IL1β), and coagulation (C5a, D-dimer) were determined.Results: Both inflammatory markers and oxidative stress differed significantly between the three clinical groups. GSH revealed a significant difference between the T2DM (1456.6 µM/mL ± 737.5, p<0.03) and obese groups (1890.7 µM/mL ± 823.3). 8-OHdG increased significantly in the obese group (185.5ng/mL ± 162.4, p<0.03) compared to the control group (146.8ng/mL ± 127.5). Similarly 8-OHdG was significantly higher in the obesity group (185.5ng/mL ± 162.4) compared to the T2DM group (119.2ng/mL ± 92.9, p<0.03). A significant increase was also found for 8-iso-PGF 2α in the diabesity group (2.3 ± 15.0 ng/mL) compared to the control group (1.0 ± 1.9 ng/mL, p<0.03) and the T2DM group (1.1±2.5ng/mL, p<0.05). 8-iso-PGF 2α in the diabesity group (2.3±15.0 ng/mL) was significantly higher than the obese group (1.1ng/mL ±1.8, p<0.03). A significant decrease occurred in IGF-1 levels for diabesity (144.6 ± 285.7 ng/mL) compared to the control (302.8 ± 547.2 ng/mL, p <0.03) and the T2DM groups (225.1ng/mL ± 417, p<0.05). A statistically significant increase in the inflammatory marker ratio IL-6/IL-10 between the control group (0.41 ± 0.7) and the obesity group (0.71 ± 1.94, p<0.03) was also observed. Conclusion:The results obtained indicate that 8-iso-PGF 2α , 8-OHdG as markers of oxidative stress and IGF-1, IL-6/IL-10 are associated with diabesity and could be used diagnostically for risk assessment.markers in obesity [10,11]. The link between inflammatory and oxidative stress markers observed in obesity is also a contributory factor in the development of T2DM and CVD [8,12].The inflammatory process in obesity includes the activation of macrophages to produce pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-6 (IL-6) [13][14][15]. These proinflammatory cytokines lead to increased levels of C-reactive protein (CRP) with a demonstrable decrease in the anti-inflammatory interleukin-10 (IL-10). IL-1β, IL-6, CRP and IL-10 are linked to abnormal fat and glucose metabolism, which provides further evidence of ...

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D-dimer Levels in Chronic Kidney Illness: A Comprehensive and Systematic Literature Review

Vahdat

Shahidi

2020

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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D-dimer identifies stages in the progression of diabetes mellitus from family history of diabetes to cardiovascular complications

Cited by 46 publications

References 26 publications

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Diabesity Increases Inflammation and Oxidative Stress

D-dimer Levels in Chronic Kidney Illness: A Comprehensive and Systematic Literature Review

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