D‐dimer level for ruling out peripherally inserted central catheter‐associated upper extremity deep vein thrombosis and superficial vein thrombosis

Liu, Wanli; He, Lei; Zeng, Wenyi; Yue, Liqing; Wei, Jie; Zeng, Shuangshuang; Wang, Xiang; Gong, Zhicheng

doi:10.1002/nop2.998

Cited by 4 publications

(6 citation statements)

References 35 publications

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“…In total, this review included twelve biomarkers in twenty-eight articles: twelve articles [ 3 , 8 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ] were analyzed via meta-analysis; twelve articles [ 5 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ] were analyzed qualitatively; and four articles [ 1 , 34 , 35 , 36 ] were analyzed via meta-analysis and qualitatively. Table S1 describes the characteristics of the studies included in the meta-analysis, and Figure 2 and Figure 3 illustrate the meta-analysis results.…”

Section: Resultsmentioning

confidence: 99%

“…In all the studies, a final assessment was carried out and the following outcomes were reported: platelets (23 articles) [ 1 , 3 , 8 , 13 , 14 , 15 , 16 , 18 , 19 , 21 , 22 , 23 , 25 , 26 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ], followed by white cells (15 articles) [ 1 , 3 , 13 , 15 , 18 , 19 , 21 , 22 , 24 , 27 , 29 , 30 , 31 , 34 , 35 ], D-dimers (13 articles) [ 3 , 8 , 13 , 17 , 19 , 21 , 23 , 26 , 27 , 28 , 34 , 35 , 36 ], fibrinogen (10 articles) [ 3 , 8 , 13 , 20 , 21 ,…”

Section: Resultsmentioning

confidence: 99%

“…Out of the 28 studies, 20 included the oncological and hematological population [ 8 , 13 , 14 , 15 , 18 , 19 , 22 , 23 , 24 , 25 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ] and seven studies included hospitalized patients [ 1 , 3 , 5 , 16 , 17 , 20 , 28 ]. Out of the 28 studies, only two included children and adolescents [ 26 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the study design, 18 were retrospective [ 3 , 8 , 14 , 15 , 16 , 17 , 20 , 21 , 22 , 23 , 24 , 25 , 28 , 30 , 31 , 32 , 33 , 36 ] and 10 were prospective [ 1 , 5 , 13 , 18 , 19 , 26 , 27 , 29 , 34 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…Another retrospective cohort study on 1312 breast cancer patients showed that D-dimer was considered a significant PICC-RVT predictive factor (OR 3.673; CI 95% 1.698–7.946; p = 0.001) [ 23 ]. However, three studies showed no association between D-dimer- and PICC-related DVT [ 26 , 28 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

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Biomarkers Associated with Thrombosis in Patients with Peripherally Inserted Central Catheter: A Systematic Review and Meta-Analysis

Cardoso

Rabelo‐Silva

Bock

et al. 2023

JCM

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Background: The measurement and identification of plasma biomarkers can support the estimation of risk and diagnosis of deep vein thrombosis (DVT) associated with the use of a peripherally inserted central catheter (PICC). Objectives: This systematic review and meta-analysis aimed to identify the association between the levels of potential biomarkers that reflect the activation of the blood system, long-term vascular complications, inflammatory system, and the occurrence of PICC-related DVT. Methods: Seven electronic databases (Embase, Web of Science, Medline, Scopus, Cinahl, Cochrane Central Register of Controlled Trials, and ERIC) were searched to identify literature published until December 2022. Studies were required to report: (I) adult and pediatric patients, outpatient or admitted to clinical, surgical, or ICU with PICC; (II) patients with PICC-related DVT and patients without PICC-related DVT as a comparator; and (III) at least one biomarker available. The Newcastle–Ottawa Scale was used to evaluate the quality of the studies. Study precision was evaluated by using a funnel plot for platelets level. We provided a narrative synthesis and meta-analysis of the findings on the biomarkers’ outcomes of the studies. We pooled the results using random effects meta-analysis. The meta-analysis was conducted using Review Manager software v5.4. This systematic review is registered in PROSPERO (CRD42018108871). Results: Of the 3564 studies identified (after duplication removal), 28 were included. PICC-related DVT was associated with higher D-dimers (0.37 μg/mL, 95% CI 0.02, 0.72; p = 0.04, I2 = 92%; p for heterogeneity < 0.00001) and with higher platelets (8.76 × 109/L, 95% CI 1.62, 15.91; p = 0.02, I2 = 41%; p for heterogeneity = 0.06). Conclusions: High levels of D-dimer and platelet were associated with DVT in patients with PICC. However, biomarkers such as APTT, fibrinogen, FDP, glucose, hemoglobin, glycated hemoglobin, INR, prothrombin time, prothrombin fragment 1.2, the thrombin–antithrombin complex, and WBC were not related to the development of DVT associated with PICC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Biomarkers Associated with Thrombosis in Patients with Peripherally Inserted Central Catheter: A Systematic Review and Meta-Analysis

Cardoso

Rabelo‐Silva

Bock

et al. 2023

JCM

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D‐dimer level for ruling out peripherally inserted central catheter‐associated upper extremity deep vein thrombosis and superficial vein thrombosis

Liu

Zeng

et al. 2021

Nursing Open

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Which is the safer option for adult patients between peripherally inserted central catheters and midline catheters: a meta-analysis

Wen,

Xiong,

et al. 2024

Infect. Control Hosp. Epidemiol.

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Background: Peripherally inserted central catheters (PICC) and midline catheters (MC) are widely used for intravenous infusions in oncology and critically ill patients. However, controversy remains regarding which method is superior. This meta-analysis systematically compares the safety differences between these 2 methods of intravenous catheterization. Methods: Eligible studies comparing PICC and MC were identified through searches in 6 databases. Thrombosis is the primary endpoint, while secondary endpoints include other complications, cost, and satisfaction rate. Results: Fourteen studies with 20,675 patients were analyzed. Based on patient data, the MC group exhibited higher rates of catheter-related superficial vein thrombosis (SVT) (risk ratio [RR]: 0.42 [0.28, 0.64]), infiltrations (RR: 0.27 [0.12, 0.62]), and leaks (RR: 0.16 [0.05, 0.53]). In contrast, the PICC group had more catheter-related bloodstream infections (RR: 1.95 [1.15, 3.32]). Considering catheter days, the MC group showed increased total complications (RR: 0.51 [0.26, 0.99]), catheter-related thrombosis (deep vein thrombosis [DVT]+SVT) (RR: 0.41 [0.18, 0.95]), and leaks (RR: 0.17 [0.05, 0.64]). In the PICC group, the top 3 complications were catheter occlusions (20 per 1,000 catheter days [CDs]), pain (15 per 1,000 CDs), and phlebitis (11 per 1,000 CDs); for the MC group, they were leaks (33 per 1,000 CDs), premature removals (22 per 1,000 CDs), and catheter-related DVT (22 per 1,000 CDs). Additionally, the PICC group had higher dissatisfaction rates (RR: 4.77 [2.33, 9.77]) and increased costs. Conclusions: Compared to MC, PICC appears to be a safer intravenous catheterization option for adult patients, exhibiting fewer complications. However, the higher associated costs and lower satisfaction rates of PICC warrant serious attention.

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D‐dimer level for ruling out peripherally inserted central catheter‐associated upper extremity deep vein thrombosis and superficial vein thrombosis

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 4 publications

References 35 publications

Biomarkers Associated with Thrombosis in Patients with Peripherally Inserted Central Catheter: A Systematic Review and Meta-Analysis

Biomarkers Associated with Thrombosis in Patients with Peripherally Inserted Central Catheter: A Systematic Review and Meta-Analysis

D‐dimer level for ruling out peripherally inserted central catheter‐associated upper extremity deep vein thrombosis and superficial vein thrombosis

Which is the safer option for adult patients between peripherally inserted central catheters and midline catheters: a meta-analysis

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