d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3

Park, Young Kum; Bold, Bayarmaa; Lee, Woo Kyung; Jeon, Min-Hwan; An, Kay Hyeok; Jeong, Se Young; Shim, Young Key

doi:10.3390/ijms12052946

Cited by 31 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…D-(+)-galactose conjugated SWNTs were synthesized using molybdenum electrodes for application as biosensors to detect cancer marker galactin-3 (Park et al, 2011 ).…”

Section: Carbon Nanotubes For Biosensing Applicationsmentioning

confidence: 99%

Carbon nanotube biosensors

2015

View full text Add to dashboard Cite

Nanomaterials possess unique features which make them particularly attractive for biosensing applications. In particular, carbon nanotubes (CNTs) can serve as scaffolds for immobilization of biomolecules at their surface, and combine several exceptional physical, chemical, electrical, and optical characteristics properties which make them one of the best suited materials for the transduction of signals associated with the recognition of analytes, metabolites, or disease biomarkers. Here we provide a comprehensive review on these carbon nanostructures, in which we describe their structural and physical properties, functionalization and cellular uptake, biocompatibility, and toxicity issues. We further review historical developments in the field of biosensors, and describe the different types of biosensors which have been developed over time, with specific focus on CNT-conjugates engineered for biosensing applications, and in particular detection of cancer biomarkers.

show abstract

“…D-(+)-galactose conjugated SWNTs were synthesized using molybdenum electrodes for application as biosensors to detect cancer marker galactin-3 (Park et al, 2011 ).…”

Section: Carbon Nanotubes For Biosensing Applicationsmentioning

confidence: 99%

Carbon nanotube biosensors

2015

View full text Add to dashboard Cite

show abstract

“…Park et al , immobilized D-(+)-galactose on SWCNTs functionalized with –COCl without causing any major structural alterations in the nanomaterials [76]. The D-(+)-galactose conjugated SWCNTs were then dropped onto the surface of a SiO 2 substrate to fabricate molybdenum (Mo) electrodes that were used in the prepared electrochemical biosensor for the detection of galectin-3, a cancer marker.…”

Section: Carbon Nanotubes (Cnts)mentioning

confidence: 99%

“…The D-(+)-galactose conjugated SWCNTs were then dropped onto the surface of a SiO 2 substrate to fabricate molybdenum (Mo) electrodes that were used in the prepared electrochemical biosensor for the detection of galectin-3, a cancer marker. The electrochemical response of the D-(+)-galactose-conjugated SWCNTs differed significantly between the samples with and without galectin-3 [76]. Therefore, these modified CNTs can potentially be useful in electrochemical biosensors for the detection of galectin-3.…”

Section: Carbon Nanotubes (Cnts)mentioning

confidence: 99%

Immobilization Techniques in the Fabrication of Nanomaterial-Based Electrochemical Biosensors: A Review

Putzbach

Ronkainen

2013

Sensors

430

252

View full text Add to dashboard Cite

The evolution of 1st to 3rd generation electrochemical biosensors reflects a simplification and enhancement of the transduction pathway. However, in recent years, modification of the transducer with nanomaterials has become increasingly studied and imparts many advantages. The sensitivity and overall performance of enzymatic biosensors has improved tremendously as a result of incorporating nanomaterials in their fabrication. Given the unique and favorable qualities of gold nanoparticles, graphene and carbon nanotubes as applied to electrochemical biosensors, a consolidated survey of the different methods of nanomaterial immobilization on transducer surfaces and enzyme immobilization on these species is beneficial and timely. This review encompasses modification of enzymatic biosensors with gold nanoparticles, carbon nanotubes, and graphene.

show abstract

“…High level of circulating galectin-3, a β-galactoside-binding protein, is correlated with an increased potential for malignancy. Park et al [ 60 ] constructed a FET biosensor to detect galectin-3 using d -(+)-galactose-conjugated SWCNTs as chemical probes. The sensing platform was prepared by drop casting SWCNTs linked with d -(+)-galactose on a Mo electrode prepatterned SiO 2 substrate, printed using conventional photolithography.…”

Section: Detection Of Cancer and Disease Biomarkersmentioning

confidence: 99%

Carbon Nanomaterial Based Biosensors for Non-Invasive Detection of Cancer and Disease Biomarkers for Clinical Diagnosis

Pasinszki

Krebsz

Tung

et al. 2017

Sensors

146

View full text Add to dashboard Cite

The early diagnosis of diseases, e.g., Parkinson’s and Alzheimer’s disease, diabetes, and various types of cancer, and monitoring the response of patients to the therapy plays a critical role in clinical treatment; therefore, there is an intensive research for the determination of many clinical analytes. In order to achieve point-of-care sensing in clinical practice, sensitive, selective, cost-effective, simple, reliable, and rapid analytical methods are required. Biosensors have become essential tools in biomarker sensing, in which electrode material and architecture play critical roles in achieving sensitive and stable detection. Carbon nanomaterials in the form of particle/dots, tube/wires, and sheets have recently become indispensable elements of biosensor platforms due to their excellent mechanical, electronic, and optical properties. This review summarizes developments in this lucrative field by presenting major biosensor types and variability of sensor platforms in biomedical applications.

show abstract

d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3

Cited by 31 publications

References 30 publications

Carbon nanotube biosensors

Carbon nanotube biosensors

Immobilization Techniques in the Fabrication of Nanomaterial-Based Electrochemical Biosensors: A Review

Carbon Nanomaterial Based Biosensors for Non-Invasive Detection of Cancer and Disease Biomarkers for Clinical Diagnosis

Contact Info

Product

Resources

About