D-glucose functionalized β-cyclodextrin as a controlled anticancer drug carrier for in vitro evaluation

Toomari, Yousef; Ebrahimpour, Hediyeh; Pooresmaeil, Malihe; Namazi, Hassan

doi:10.1007/s00289-022-04280-5

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…The three most commonly used CDs are α-, β-, and γ-CDs, consisting of six, seven, and eight glucose units, respectively (Figure ). CDs have garnered significant attention over the past few decades as a remarkable biobased material with diverse applications in various fields such as biomedical, biosensor, environmental, and food science. − Their unique ability to act as a host molecule for a variety of inorganic, organic, and biological molecules, permitting their stabilization and solubilization, makes CDs an attractive material for the development of functional materials. − CD-functionalized materials can make suitable interactions with an analyte and provide an excellent platform for diverse applications in biosensing. − These features make them ideal candidates for application in glucose sensor systems, which are the subject of this review.…”

Section: Cyclodextrin-based Gm Sensorsmentioning

confidence: 99%

Cyclodextrin Host–Guest Recognition in Glucose-Monitoring Sensors

Javanbakht,

Darvishi,

Dorchei

et al. 2023

ACS Omega

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Diabetes mellitus is a prevalent chronic health condition that has caused millions of deaths worldwide. Monitoring blood glucose levels is crucial in diabetes management, aiding in clinical decision making and reducing the incidence of hypoglycemic episodes, thereby decreasing morbidity and mortality rates. Despite advancements in glucose monitoring (GM), the development of noninvasive, rapid, accurate, sensitive, selective, and stable systems for continuous monitoring remains a challenge. Addressing these challenges is critical to improving the clinical utility of GM technologies in diabetes management. In this concept, cyclodextrins (CDs) can be instrumental in the development of GM systems due to their high supramolecular recognition capabilities based on the host–guest interaction. The introduction of CDs into GM systems not only impacts the sensitivity, selectivity, and detection limit of the monitoring process but also improves biocompatibility and stability. These findings motivated the current review to provide a comprehensive summary of CD-based blood glucose sensors and their chemistry of glucose detection, efficiency, and accuracy. We categorize CD-based sensors into four groups based on their modification strategies, including CD-modified boronic acid, CD-modified mediators, CD-modified nanoparticles, and CD-modified functionalized polymers. These findings shed light on the potential of CD-based sensors as a promising tool for continuous GM in diabetes mellitus management.

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